Tags

Type your tag names separated by a space and hit enter

Toxic effects of bisphenol A on early life stages of Japanese medaka (Oryzias latipes).
Bull Environ Contam Toxicol. 2014 Aug; 93(2):222-7.BE

Abstract

The toxic effects of bisphenol A (BPA) in aquatic organisms have attracted global attention. However, few studies have investigated its effects at the gene transcription level. In this study, we measured the transcriptional response of a set of genes associated with the hypothalamic-pituitary-gonadal axis following BPA exposure during the early life stage of Japanese medaka. Transcription of vitellogenin genes was induced in both sexes, indicating estrogenic disruption. However, changes in transcription of the steroid hormone receptor gene and steroidogenesis-regulating genes suggest that BPA also acts as an androgen receptor antagonist. BPA exposure also decreased the hatchability of medaka embryos and increased the growth of female larvae. These pronounced gender-specific effects observed in this study demonstrate that it is important to identify the sex of fish in the early life stage.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Sun L
College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310032, People's Republic of China.
Lin X
No affiliation info available
Jin R
No affiliation info available
Peng T
No affiliation info available
Peng Z
No affiliation info available
Fu Z
No affiliation info available

MeSH

AnimalsBenzhydryl CompoundsEstrogens, Non-SteroidalFemaleFish ProteinsGene Expression RegulationLarvaMaleOryziasPhenolsVitellogeninsWater Pollutants, Chemical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24849714

Citation

Sun, Liwei, et al. "Toxic Effects of Bisphenol a On Early Life Stages of Japanese Medaka (Oryzias Latipes)." Bulletin of Environmental Contamination and Toxicology, vol. 93, no. 2, 2014, pp. 222-7.
Sun L, Lin X, Jin R, et al. Toxic effects of bisphenol A on early life stages of Japanese medaka (Oryzias latipes). Bull Environ Contam Toxicol. 2014;93(2):222-7.
Sun, L., Lin, X., Jin, R., Peng, T., Peng, Z., & Fu, Z. (2014). Toxic effects of bisphenol A on early life stages of Japanese medaka (Oryzias latipes). Bulletin of Environmental Contamination and Toxicology, 93(2), 222-7. https://doi.org/10.1007/s00128-014-1298-2
Sun L, et al. Toxic Effects of Bisphenol a On Early Life Stages of Japanese Medaka (Oryzias Latipes). Bull Environ Contam Toxicol. 2014;93(2):222-7. PubMed PMID: 24849714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxic effects of bisphenol A on early life stages of Japanese medaka (Oryzias latipes). AU - Sun,Liwei, AU - Lin,Xia, AU - Jin,Rong, AU - Peng,Tao, AU - Peng,Zuhua, AU - Fu,Zhengwei, Y1 - 2014/05/22/ PY - 2013/11/13/received PY - 2014/05/10/accepted PY - 2014/5/23/entrez PY - 2014/5/23/pubmed PY - 2014/9/26/medline SP - 222 EP - 7 JF - Bulletin of environmental contamination and toxicology JO - Bull Environ Contam Toxicol VL - 93 IS - 2 N2 - The toxic effects of bisphenol A (BPA) in aquatic organisms have attracted global attention. However, few studies have investigated its effects at the gene transcription level. In this study, we measured the transcriptional response of a set of genes associated with the hypothalamic-pituitary-gonadal axis following BPA exposure during the early life stage of Japanese medaka. Transcription of vitellogenin genes was induced in both sexes, indicating estrogenic disruption. However, changes in transcription of the steroid hormone receptor gene and steroidogenesis-regulating genes suggest that BPA also acts as an androgen receptor antagonist. BPA exposure also decreased the hatchability of medaka embryos and increased the growth of female larvae. These pronounced gender-specific effects observed in this study demonstrate that it is important to identify the sex of fish in the early life stage. SN - 1432-0800 UR - https://www.unboundmedicine.com/medline/citation/24849714/Toxic_effects_of_bisphenol_A_on_early_life_stages_of_Japanese_medaka__Oryzias_latipes__ DB - PRIME DP - Unbound Medicine ER -