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Horsfiequinones A-F, dimeric diarylpropanoids from Horsfieldia tetratepala.
Planta Med. 2014 Jun; 80(8-9):688-94.PM

Abstract

A new diarylpropanoid, horsfiequinone A (1), and five new dimeric diarylpropanoids with 1,4-p-benzoquinone residue, horsfiequinones B-F (2-6), along with a known compound, combrequinone B (7), were isolated from Horsfieldia tetratepala. Their structures were elucidated by means of spectroscopic analysis. Horsfiequinones B-F (2-6), isolated as enantiomer mixtures with unequal proportions, were verified by analysis on a chiral OD-H HPLC column. Cytotoxicity evaluation against five human tumor lines showed selective inhibitory effects on HL-60 for several compounds tested with IC50 values ranging from 3.18 ± 0.67 to 6.61 ± 0.08 µM.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ma Q
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Min K
Diqing Institute of Agricultural Science, Shangrila, Yunnan, China.
Li HL
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Jiang JH
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Liu Y
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Zhan R
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.
Chen YG
School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China.

MeSH

Antineoplastic Agents, PhytogenicBenzoquinonesCell Line, TumorCell SurvivalHumansInhibitory Concentration 50Molecular StructureMyristicaceaePlant ExtractsPlant LeavesPlant StemsPropanols

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24853763

Citation

Ma, Qin, et al. "Horsfiequinones A-F, Dimeric Diarylpropanoids From Horsfieldia Tetratepala." Planta Medica, vol. 80, no. 8-9, 2014, pp. 688-94.
Ma Q, Min K, Li HL, et al. Horsfiequinones A-F, dimeric diarylpropanoids from Horsfieldia tetratepala. Planta Med. 2014;80(8-9):688-94.
Ma, Q., Min, K., Li, H. L., Jiang, J. H., Liu, Y., Zhan, R., & Chen, Y. G. (2014). Horsfiequinones A-F, dimeric diarylpropanoids from Horsfieldia tetratepala. Planta Medica, 80(8-9), 688-94. https://doi.org/10.1055/s-0034-1368456
Ma Q, et al. Horsfiequinones A-F, Dimeric Diarylpropanoids From Horsfieldia Tetratepala. Planta Med. 2014;80(8-9):688-94. PubMed PMID: 24853763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Horsfiequinones A-F, dimeric diarylpropanoids from Horsfieldia tetratepala. AU - Ma,Qin, AU - Min,Kang, AU - Li,Hao-Liang, AU - Jiang,Jin-He, AU - Liu,Ying, AU - Zhan,Rui, AU - Chen,Ye-Gao, Y1 - 2014/05/22/ PY - 2014/5/24/entrez PY - 2014/5/24/pubmed PY - 2015/3/31/medline SP - 688 EP - 94 JF - Planta medica JO - Planta Med VL - 80 IS - 8-9 N2 - A new diarylpropanoid, horsfiequinone A (1), and five new dimeric diarylpropanoids with 1,4-p-benzoquinone residue, horsfiequinones B-F (2-6), along with a known compound, combrequinone B (7), were isolated from Horsfieldia tetratepala. Their structures were elucidated by means of spectroscopic analysis. Horsfiequinones B-F (2-6), isolated as enantiomer mixtures with unequal proportions, were verified by analysis on a chiral OD-H HPLC column. Cytotoxicity evaluation against five human tumor lines showed selective inhibitory effects on HL-60 for several compounds tested with IC50 values ranging from 3.18 ± 0.67 to 6.61 ± 0.08 µM. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/24853763/Horsfiequinones_A_F_dimeric_diarylpropanoids_from_Horsfieldia_tetratepala_ DB - PRIME DP - Unbound Medicine ER -