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Tubular dysfunction in the early stage of diabetic nephropathy.
Med J Osaka Univ 1989; 38(1-4):57-63MJ

Abstract

Renal tubular function was investigated in 98 non-insulin-dependent and 18 insulin-dependent diabetics under conditions of standard glycemic control. Mean urinary excretion of lysozyme, beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) in both Albustix-negative and positive patients were significantly elevated above the control range. The increased excretion of lysozyme, beta 2-microglobulin and NAG was found in 21, 55 and 62% of the normoalbuminuric patients, and in 40, 57 and 74% of the microalbuminuric patients, respectively. Besides the parameters cited above, urinary acid-soluble glycoprotein (ASP) was measured to assess its potential as an indicator of early renal dysfunction. Mean urinary ASP excretion was also elevated in both Albustix-negative and positive patients. The albumin/ASP ratio increased as nephropathy advanced. Such a mode of excretion was similar to those of low-molecular-weight proteins (lysozyme and beta 2-microglobulin). The results of multiple regression analysis showed that serum creatinine most highly correlated with the excretion of the urinary proteins except for NAG.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2485397

Citation

Tanaka, A, et al. "Tubular Dysfunction in the Early Stage of Diabetic Nephropathy." Medical Journal of Osaka University, vol. 38, no. 1-4, 1989, pp. 57-63.
Tanaka A, Shima K, Fukuda M, et al. Tubular dysfunction in the early stage of diabetic nephropathy. Med J Osaka Univ. 1989;38(1-4):57-63.
Tanaka, A., Shima, K., Fukuda, M., Tahara, Y., Yamamoto, Y., & Kumahara, Y. (1989). Tubular dysfunction in the early stage of diabetic nephropathy. Medical Journal of Osaka University, 38(1-4), pp. 57-63.
Tanaka A, et al. Tubular Dysfunction in the Early Stage of Diabetic Nephropathy. Med J Osaka Univ. 1989;38(1-4):57-63. PubMed PMID: 2485397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tubular dysfunction in the early stage of diabetic nephropathy. AU - Tanaka,A, AU - Shima,K, AU - Fukuda,M, AU - Tahara,Y, AU - Yamamoto,Y, AU - Kumahara,Y, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 57 EP - 63 JF - Medical journal of Osaka University JO - Med J Osaka Univ VL - 38 IS - 1-4 N2 - Renal tubular function was investigated in 98 non-insulin-dependent and 18 insulin-dependent diabetics under conditions of standard glycemic control. Mean urinary excretion of lysozyme, beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) in both Albustix-negative and positive patients were significantly elevated above the control range. The increased excretion of lysozyme, beta 2-microglobulin and NAG was found in 21, 55 and 62% of the normoalbuminuric patients, and in 40, 57 and 74% of the microalbuminuric patients, respectively. Besides the parameters cited above, urinary acid-soluble glycoprotein (ASP) was measured to assess its potential as an indicator of early renal dysfunction. Mean urinary ASP excretion was also elevated in both Albustix-negative and positive patients. The albumin/ASP ratio increased as nephropathy advanced. Such a mode of excretion was similar to those of low-molecular-weight proteins (lysozyme and beta 2-microglobulin). The results of multiple regression analysis showed that serum creatinine most highly correlated with the excretion of the urinary proteins except for NAG. SN - 0030-6169 UR - https://www.unboundmedicine.com/medline/citation/2485397/Tubular_dysfunction_in_the_early_stage_of_diabetic_nephropathy_ L2 - https://medlineplus.gov/diabetickidneyproblems.html DB - PRIME DP - Unbound Medicine ER -