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Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats.
Geriatr Gerontol Int 2014; 14(4):996-1002GG

Abstract

AIM

Olive leaf (Olea europaea L.) extract (OLE) is a powerful anti-oxidant rich in polyphenols. As oxidative stress plays an important role in aging, we investigated the effect of OLE on oxidative stress in the liver, heart and brain of aged rats.

METHODS

Young (age 3 months) and aged (age 20 months) Wistar rats were used. Aged rats received OLE (500 and 1000 mg/kg/day) in drinking water for 2 months. Malondialdehyde (MDA), diene conjugate (DC), protein carbonyl (PC), glutathione (GSH), vitamin E and vitamin C levels, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined.

RESULTS

MDA, DC and PC levels increased in tissues of aged rats. GSH levels decreased in the liver, but not in the heart and brain. There was no change of other anti-oxidant parameters in tissues. Hepatic SOD and GSH-Px protein expressions also remained unchanged. OLE treatment caused decreased tissue MDA, DC and PC levels, and increased hepatic GSH levels in aged rats. Other anti-oxidant parameters, hepatic SOD and GSH-Px protein expressions did not alter in aged rats by OLE treatment.

CONCLUSION

The present results suggest that OLE seems to be useful for decreasing oxidative stress in examined tissues by acting as an anti-oxidant itself without affecting the anti-oxidant system.

Authors+Show Affiliations

Department of Biochemistry, Yeditepe University Medical Faculty, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24854676

Citation

Çoban, Jale, et al. "Olive Leaf Extract Decreases Age-induced Oxidative Stress in Major Organs of Aged Rats." Geriatrics & Gerontology International, vol. 14, no. 4, 2014, pp. 996-1002.
Çoban J, Öztezcan S, Doğru-Abbasoğlu S, et al. Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats. Geriatr Gerontol Int. 2014;14(4):996-1002.
Çoban, J., Öztezcan, S., Doğru-Abbasoğlu, S., Bingül, I., Yeşil-Mizrak, K., & Uysal, M. (2014). Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats. Geriatrics & Gerontology International, 14(4), pp. 996-1002. doi:10.1111/ggi.12192.
Çoban J, et al. Olive Leaf Extract Decreases Age-induced Oxidative Stress in Major Organs of Aged Rats. Geriatr Gerontol Int. 2014;14(4):996-1002. PubMed PMID: 24854676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats. AU - Çoban,Jale, AU - Öztezcan,Serdar, AU - Doğru-Abbasoğlu,Semra, AU - Bingül,Ilknur, AU - Yeşil-Mizrak,Kübra, AU - Uysal,Müjdat, Y1 - 2014/05/23/ PY - 2013/10/10/accepted PY - 2014/5/24/entrez PY - 2014/5/24/pubmed PY - 2015/6/24/medline KW - aging KW - olive leaf extract KW - oxidative stress KW - rats KW - tissues SP - 996 EP - 1002 JF - Geriatrics & gerontology international JO - Geriatr Gerontol Int VL - 14 IS - 4 N2 - AIM: Olive leaf (Olea europaea L.) extract (OLE) is a powerful anti-oxidant rich in polyphenols. As oxidative stress plays an important role in aging, we investigated the effect of OLE on oxidative stress in the liver, heart and brain of aged rats. METHODS: Young (age 3 months) and aged (age 20 months) Wistar rats were used. Aged rats received OLE (500 and 1000 mg/kg/day) in drinking water for 2 months. Malondialdehyde (MDA), diene conjugate (DC), protein carbonyl (PC), glutathione (GSH), vitamin E and vitamin C levels, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined. RESULTS: MDA, DC and PC levels increased in tissues of aged rats. GSH levels decreased in the liver, but not in the heart and brain. There was no change of other anti-oxidant parameters in tissues. Hepatic SOD and GSH-Px protein expressions also remained unchanged. OLE treatment caused decreased tissue MDA, DC and PC levels, and increased hepatic GSH levels in aged rats. Other anti-oxidant parameters, hepatic SOD and GSH-Px protein expressions did not alter in aged rats by OLE treatment. CONCLUSION: The present results suggest that OLE seems to be useful for decreasing oxidative stress in examined tissues by acting as an anti-oxidant itself without affecting the anti-oxidant system. SN - 1447-0594 UR - https://www.unboundmedicine.com/medline/citation/24854676/Olive_leaf_extract_decreases_age_induced_oxidative_stress_in_major_organs_of_aged_rats_ L2 - https://doi.org/10.1111/ggi.12192 DB - PRIME DP - Unbound Medicine ER -