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[Relationship between metabolic diseases and all-cause and cardiovascular death in an elderly male population during a 15-year follow-up].
Zhonghua Yi Xue Za Zhi. 2014 Apr 01; 94(12):913-8.ZY

Abstract

OBJECTIVE

To explore the relationship between metabolic diseases and death from all causes, cardiovascular diseases (CVD) in an elderly male population.

METHODS

A cohort of 1 447 elderly males was followed up for 15 years from 1996 to 2011. All of them received annual check-ups at our hospital. The Cox proportional hazard model was applied to multivariate survival analysis for all-cause and CVD mortality. And the cumulative survival rates were calculated by Kaplan-Meier method and log-rank test was used to compare the survival rates.

RESULTS

During a 15-year follow-up, 639 subjects died, including 186 deaths from cardiovascular causes. Multivariate Cox regression analysis showed that age [relative risk (RR) = 1.131, 95% confidence interval (CI) 1.114-1.148], impaired glucose metabolism (RR = 1.344, 95% CI 1.139-1.585), hypertension (RR = 1.241, 95% CI 1.055-1.460) , elevated fasting glucose level (RR = 1.101, 95% CI 1.031-1.177) and lower body mass index (BMI) (RR = 0.968, 95% CI 0.943-0.993) increased the risks of all-cause mortality while age (RR = 1.119, 95% CI 1.086-1.153) , impaired glucose metabolism (RR = 1.856, 95% CI 1.386-2.458) and hypertension (RR = 1.699, 95% CI 1.242-2.324) elevated the risks of CVD mortality. The cumulative survival rates from all-cause and CVD mortality in impaired glucose regulation and diabetes group were significantly lower than those in normal glucose tolerance group (P < 0.01) . However, no difference existed between impaired glucose regulation (IGR) and diabetes groups. The cumulative survival rates from all-cause and CVD mortality significantly decreased in cases of impaired glucose metabolism and hypertension (P < 0.01) . The cumulative survival rates from all-cause mortality in low BMI group were significantly lower than those in normal and high BMI groups (P < 0.05) . A substantially higher risk of all-cause and CVD mortality was present in those with 2 or more metabolic disorders versus those with 0-1 metabolic disorder (P < 0.01).

CONCLUSIONS

Malignant tumor and CVD are the main cause of death for Chinese elderly male population. Advanced age, impaired glucose metabolism, hypertension and 2 or more concurrent metabolic disorders are risk factors of all-cause and CVD mortality. And underweight is associated with an increased risk of death in elders.

Authors+Show Affiliations

Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China. Email: tianhui@medmail.com.Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

24854911

Citation

Sun, Banruo, et al. "[Relationship Between Metabolic Diseases and All-cause and Cardiovascular Death in an Elderly Male Population During a 15-year Follow-up]." Zhonghua Yi Xue Za Zhi, vol. 94, no. 12, 2014, pp. 913-8.
Sun B, Shao Y, Li J, et al. [Relationship between metabolic diseases and all-cause and cardiovascular death in an elderly male population during a 15-year follow-up]. Zhonghua Yi Xue Za Zhi. 2014;94(12):913-8.
Sun, B., Shao, Y., Li, J., Tian, H., & Li, C. (2014). [Relationship between metabolic diseases and all-cause and cardiovascular death in an elderly male population during a 15-year follow-up]. Zhonghua Yi Xue Za Zhi, 94(12), 913-8.
Sun B, et al. [Relationship Between Metabolic Diseases and All-cause and Cardiovascular Death in an Elderly Male Population During a 15-year Follow-up]. Zhonghua Yi Xue Za Zhi. 2014 Apr 1;94(12):913-8. PubMed PMID: 24854911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between metabolic diseases and all-cause and cardiovascular death in an elderly male population during a 15-year follow-up]. AU - Sun,Banruo, AU - Shao,Yinghong, AU - Li,Jian, AU - Tian,Hui, AU - Li,Chunlin, PY - 2014/5/24/entrez PY - 2014/5/24/pubmed PY - 2015/2/6/medline SP - 913 EP - 8 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 94 IS - 12 N2 - OBJECTIVE: To explore the relationship between metabolic diseases and death from all causes, cardiovascular diseases (CVD) in an elderly male population. METHODS: A cohort of 1 447 elderly males was followed up for 15 years from 1996 to 2011. All of them received annual check-ups at our hospital. The Cox proportional hazard model was applied to multivariate survival analysis for all-cause and CVD mortality. And the cumulative survival rates were calculated by Kaplan-Meier method and log-rank test was used to compare the survival rates. RESULTS: During a 15-year follow-up, 639 subjects died, including 186 deaths from cardiovascular causes. Multivariate Cox regression analysis showed that age [relative risk (RR) = 1.131, 95% confidence interval (CI) 1.114-1.148], impaired glucose metabolism (RR = 1.344, 95% CI 1.139-1.585), hypertension (RR = 1.241, 95% CI 1.055-1.460) , elevated fasting glucose level (RR = 1.101, 95% CI 1.031-1.177) and lower body mass index (BMI) (RR = 0.968, 95% CI 0.943-0.993) increased the risks of all-cause mortality while age (RR = 1.119, 95% CI 1.086-1.153) , impaired glucose metabolism (RR = 1.856, 95% CI 1.386-2.458) and hypertension (RR = 1.699, 95% CI 1.242-2.324) elevated the risks of CVD mortality. The cumulative survival rates from all-cause and CVD mortality in impaired glucose regulation and diabetes group were significantly lower than those in normal glucose tolerance group (P < 0.01) . However, no difference existed between impaired glucose regulation (IGR) and diabetes groups. The cumulative survival rates from all-cause and CVD mortality significantly decreased in cases of impaired glucose metabolism and hypertension (P < 0.01) . The cumulative survival rates from all-cause mortality in low BMI group were significantly lower than those in normal and high BMI groups (P < 0.05) . A substantially higher risk of all-cause and CVD mortality was present in those with 2 or more metabolic disorders versus those with 0-1 metabolic disorder (P < 0.01). CONCLUSIONS: Malignant tumor and CVD are the main cause of death for Chinese elderly male population. Advanced age, impaired glucose metabolism, hypertension and 2 or more concurrent metabolic disorders are risk factors of all-cause and CVD mortality. And underweight is associated with an increased risk of death in elders. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/24854911/[Relationship_between_metabolic_diseases_and_all_cause_and_cardiovascular_death_in_an_elderly_male_population_during_a_15_year_follow_up]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2014&amp;vol=94&amp;issue=12&amp;fpage=913 DB - PRIME DP - Unbound Medicine ER -