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[Relationship between metabolic diseases and all-cause and cardiovascular death in an elderly male population during a 15-year follow-up].
Zhonghua Yi Xue Za Zhi. 2014 Apr 01; 94(12):913-8.ZY

Abstract

OBJECTIVE

To explore the relationship between metabolic diseases and death from all causes, cardiovascular diseases (CVD) in an elderly male population.

METHODS

A cohort of 1 447 elderly males was followed up for 15 years from 1996 to 2011. All of them received annual check-ups at our hospital. The Cox proportional hazard model was applied to multivariate survival analysis for all-cause and CVD mortality. And the cumulative survival rates were calculated by Kaplan-Meier method and log-rank test was used to compare the survival rates.

RESULTS

During a 15-year follow-up, 639 subjects died, including 186 deaths from cardiovascular causes. Multivariate Cox regression analysis showed that age [relative risk (RR) = 1.131, 95% confidence interval (CI) 1.114-1.148], impaired glucose metabolism (RR = 1.344, 95% CI 1.139-1.585), hypertension (RR = 1.241, 95% CI 1.055-1.460) , elevated fasting glucose level (RR = 1.101, 95% CI 1.031-1.177) and lower body mass index (BMI) (RR = 0.968, 95% CI 0.943-0.993) increased the risks of all-cause mortality while age (RR = 1.119, 95% CI 1.086-1.153) , impaired glucose metabolism (RR = 1.856, 95% CI 1.386-2.458) and hypertension (RR = 1.699, 95% CI 1.242-2.324) elevated the risks of CVD mortality. The cumulative survival rates from all-cause and CVD mortality in impaired glucose regulation and diabetes group were significantly lower than those in normal glucose tolerance group (P < 0.01) . However, no difference existed between impaired glucose regulation (IGR) and diabetes groups. The cumulative survival rates from all-cause and CVD mortality significantly decreased in cases of impaired glucose metabolism and hypertension (P < 0.01) . The cumulative survival rates from all-cause mortality in low BMI group were significantly lower than those in normal and high BMI groups (P < 0.05) . A substantially higher risk of all-cause and CVD mortality was present in those with 2 or more metabolic disorders versus those with 0-1 metabolic disorder (P < 0.01).

CONCLUSIONS

Malignant tumor and CVD are the main cause of death for Chinese elderly male population. Advanced age, impaired glucose metabolism, hypertension and 2 or more concurrent metabolic disorders are risk factors of all-cause and CVD mortality. And underweight is associated with an increased risk of death in elders.

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Publisher Full Text

Authors+Show Affiliations

Sun B
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Shao Y
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Li J
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
Tian H
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China. Email: tianhui@medmail.com.
Li C
Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.

MeSH

AgedAged, 80 and overBlood GlucoseCardiovascular DiseasesCause of DeathFollow-Up StudiesHumansHypertensionKaplan-Meier EstimateMaleMetabolic DiseasesMultivariate AnalysisNeoplasmsProportional Hazards ModelsRisk FactorsSurvival Rate

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

24854911

Citation

Sun, Banruo, et al. "[Relationship Between Metabolic Diseases and All-cause and Cardiovascular Death in an Elderly Male Population During a 15-year Follow-up]." Zhonghua Yi Xue Za Zhi, vol. 94, no. 12, 2014, pp. 913-8.
Sun B, Shao Y, Li J, et al. [Relationship between metabolic diseases and all-cause and cardiovascular death in an elderly male population during a 15-year follow-up]. Zhonghua Yi Xue Za Zhi. 2014;94(12):913-8.
Sun, B., Shao, Y., Li, J., Tian, H., & Li, C. (2014). [Relationship between metabolic diseases and all-cause and cardiovascular death in an elderly male population during a 15-year follow-up]. Zhonghua Yi Xue Za Zhi, 94(12), 913-8.
Sun B, et al. [Relationship Between Metabolic Diseases and All-cause and Cardiovascular Death in an Elderly Male Population During a 15-year Follow-up]. Zhonghua Yi Xue Za Zhi. 2014 Apr 1;94(12):913-8. PubMed PMID: 24854911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between metabolic diseases and all-cause and cardiovascular death in an elderly male population during a 15-year follow-up]. AU - Sun,Banruo, AU - Shao,Yinghong, AU - Li,Jian, AU - Tian,Hui, AU - Li,Chunlin, PY - 2014/5/24/entrez PY - 2014/5/24/pubmed PY - 2015/2/6/medline SP - 913 EP - 8 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 94 IS - 12 N2 - OBJECTIVE: To explore the relationship between metabolic diseases and death from all causes, cardiovascular diseases (CVD) in an elderly male population. METHODS: A cohort of 1 447 elderly males was followed up for 15 years from 1996 to 2011. All of them received annual check-ups at our hospital. The Cox proportional hazard model was applied to multivariate survival analysis for all-cause and CVD mortality. And the cumulative survival rates were calculated by Kaplan-Meier method and log-rank test was used to compare the survival rates. RESULTS: During a 15-year follow-up, 639 subjects died, including 186 deaths from cardiovascular causes. Multivariate Cox regression analysis showed that age [relative risk (RR) = 1.131, 95% confidence interval (CI) 1.114-1.148], impaired glucose metabolism (RR = 1.344, 95% CI 1.139-1.585), hypertension (RR = 1.241, 95% CI 1.055-1.460) , elevated fasting glucose level (RR = 1.101, 95% CI 1.031-1.177) and lower body mass index (BMI) (RR = 0.968, 95% CI 0.943-0.993) increased the risks of all-cause mortality while age (RR = 1.119, 95% CI 1.086-1.153) , impaired glucose metabolism (RR = 1.856, 95% CI 1.386-2.458) and hypertension (RR = 1.699, 95% CI 1.242-2.324) elevated the risks of CVD mortality. The cumulative survival rates from all-cause and CVD mortality in impaired glucose regulation and diabetes group were significantly lower than those in normal glucose tolerance group (P < 0.01) . However, no difference existed between impaired glucose regulation (IGR) and diabetes groups. The cumulative survival rates from all-cause and CVD mortality significantly decreased in cases of impaired glucose metabolism and hypertension (P < 0.01) . The cumulative survival rates from all-cause mortality in low BMI group were significantly lower than those in normal and high BMI groups (P < 0.05) . A substantially higher risk of all-cause and CVD mortality was present in those with 2 or more metabolic disorders versus those with 0-1 metabolic disorder (P < 0.01). CONCLUSIONS: Malignant tumor and CVD are the main cause of death for Chinese elderly male population. Advanced age, impaired glucose metabolism, hypertension and 2 or more concurrent metabolic disorders are risk factors of all-cause and CVD mortality. And underweight is associated with an increased risk of death in elders. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/24854911/[Relationship_between_metabolic_diseases_and_all_cause_and_cardiovascular_death_in_an_elderly_male_population_during_a_15_year_follow_up]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2014&amp;vol=94&amp;issue=12&amp;fpage=913 DB - PRIME DP - Unbound Medicine ER -