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Prevention of iron deficiency by milk fortification. The Chilean experience.
Acta Paediatr Scand Suppl. 1989; 361:109-13.AP

Abstract

A large proportion of the milk consumed by infants in Chile is distributed by a National Food Supplementary Program. Efforts to prevent iron deficiency by milk fortification started several years ago. Initially a field study involving the simple addition of ferrous sulfate to a low-fat powdered milk was only partially successful due to the relatively low iron absorption from this product. Following the observation that the enrichment of milk with ascorbic acid markedly improved iron bioavailability, a new fortified formula was developed and has been tested in the field since 1976. This is powdered full-fat milk, biologically acidified and fortified with 15 mg Fe, as ferrous sulfate, and 100 mg ascorbic acid per 100 g powder. In a pilot study, 276 infants spontaneously weaned before 3 months of age received the fortified milk, and 278 infants receiving unfortified milk served as controls. At the end of the study (15 months of age) anemia (Hb less than 11 g/dl) was present in 25.7% of unfortified infants compared with only 2.5% in those fortified. Saturation of Transferrin less than 9% was present in 33.8% and serum ferritin less than 10 micrograms/l in 39.1% of the nonfortified infants. The figures for the fortified group were 7% and 8.5% respectively. Acceptance of the fortified formula was good. Following these observations, and as a previous step to the use of the fortified milk in the national program, the formula was tested in 7 National Health Service inner city community clinics under regular milk distribution.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Hematology Unit, University of Chile, Santiago.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2485578

Citation

Olivares, M, et al. "Prevention of Iron Deficiency By Milk Fortification. the Chilean Experience." Acta Paediatrica Scandinavica. Supplement, vol. 361, 1989, pp. 109-13.
Olivares M, Walter T, Hertrampf E, et al. Prevention of iron deficiency by milk fortification. The Chilean experience. Acta Paediatr Scand Suppl. 1989;361:109-13.
Olivares, M., Walter, T., Hertrampf, E., Pizarro, F., & Stekel, A. (1989). Prevention of iron deficiency by milk fortification. The Chilean experience. Acta Paediatrica Scandinavica. Supplement, 361, 109-13.
Olivares M, et al. Prevention of Iron Deficiency By Milk Fortification. the Chilean Experience. Acta Paediatr Scand Suppl. 1989;361:109-13. PubMed PMID: 2485578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of iron deficiency by milk fortification. The Chilean experience. AU - Olivares,M, AU - Walter,T, AU - Hertrampf,E, AU - Pizarro,F, AU - Stekel,A, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 109 EP - 13 JF - Acta paediatrica Scandinavica. Supplement JO - Acta Paediatr Scand Suppl VL - 361 N2 - A large proportion of the milk consumed by infants in Chile is distributed by a National Food Supplementary Program. Efforts to prevent iron deficiency by milk fortification started several years ago. Initially a field study involving the simple addition of ferrous sulfate to a low-fat powdered milk was only partially successful due to the relatively low iron absorption from this product. Following the observation that the enrichment of milk with ascorbic acid markedly improved iron bioavailability, a new fortified formula was developed and has been tested in the field since 1976. This is powdered full-fat milk, biologically acidified and fortified with 15 mg Fe, as ferrous sulfate, and 100 mg ascorbic acid per 100 g powder. In a pilot study, 276 infants spontaneously weaned before 3 months of age received the fortified milk, and 278 infants receiving unfortified milk served as controls. At the end of the study (15 months of age) anemia (Hb less than 11 g/dl) was present in 25.7% of unfortified infants compared with only 2.5% in those fortified. Saturation of Transferrin less than 9% was present in 33.8% and serum ferritin less than 10 micrograms/l in 39.1% of the nonfortified infants. The figures for the fortified group were 7% and 8.5% respectively. Acceptance of the fortified formula was good. Following these observations, and as a previous step to the use of the fortified milk in the national program, the formula was tested in 7 National Health Service inner city community clinics under regular milk distribution.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0300-8843 UR - https://www.unboundmedicine.com/medline/citation/2485578/Prevention_of_iron_deficiency_by_milk_fortification__The_Chilean_experience_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -