TY - JOUR T1 - Hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for acidic herbicides and metabolites analysis in fresh water. AU - Fauvelle,Vincent, AU - Mazzella,Nicolas, AU - Morin,Soizic, AU - Moreira,Sylvia, AU - Delest,Brigitte, AU - Budzinski,Hélène, Y1 - 2014/05/27/ PY - 2014/01/10/received PY - 2014/04/02/accepted PY - 2014/5/27/entrez PY - 2014/5/27/pubmed PY - 2015/7/15/medline SP - 3988 EP - 96 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 22 IS - 6 N2 - Theoretical papers and environmental applications of hydrophilic interaction liquid chromatography (HILIC) have been published for a wide range of analytes, but to our knowledge, no study focused on acidic herbicides (e.g., triketones, phenoxy acids, sulfonylurea, and acidic metabolites of chloroacetanilides). Matrix effects are the main obstacle to natural sample analysis by liquid chromatography coupled with tandem mass spectrometry (MS) via an electrospray ionization (ESI) interface. Therefore, we paid particular attention on limiting interference by (i) adapting the emerging HILIC technique, which is generally considered more sensitive than conventional reversed phase liquid chromatography and (ii) optimizing the solid phase extraction (SPE) step using a design of experiment. A rapid and reliable off line SPE-HILIC-ESI-MS/MS method was thus developed for the quantification of acidic herbicides in fresh water, with limits of quantifications (LOQs) ranging from 5 to 22 ng L(-1). Then, the analysis of freshwater samples highlighted the robustness of the method, and the importance of the chloroacetanilides metabolites among the studied analytes. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/24859693/Hydrophilic_interaction_liquid_chromatography_coupled_with_tandem_mass_spectrometry_for_acidic_herbicides_and_metabolites_analysis_in_fresh_water_ DB - PRIME DP - Unbound Medicine ER -