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Multiple sclerosis in gulf war era veterans. 2. Military deployment and risk of multiple sclerosis in the first gulf war.
Neuroepidemiology 2014; 42(4):226-34N

Abstract

BACKGROUND

Concern has been raised that US veterans of the 1990-1991 Gulf War (GW1) may be at increased risk to develop neurologic disease.

METHODS

An incident cohort of multiple sclerosis (MS) and other demyelinating disease (ODD) was assembled from the US military comprising the Gulf War era (1990-2007). Cases of MS and ODD meeting standard diagnostic criteria were matched to a database of all active duty personnel from the Department of Defense. Relative risk (RR) estimates for MS and all demyelinating disease based on onset, deployment status, and exposures were calculated.

RESULTS

For GW1, a total of 1,841 incident cases of definite MS and ODD were identified, with 387 among 696,118 deployed and 1,454 among 1,786,215 nondeployed personnel. The RR for MS alone among those deployed compared to those nondeployed was 0.69 (confidence interval, CI: 0.61-0.78), with 0.72 (CI: 0.62-0.83) in men and 0.96 (CI: 0.75-1.22) in women. Deployment was also nonsignificant or protective as an MS risk factor across racial groups, all age groups, and each military service. RRs for MS by service were: Air Force 0.71 (CI: 0.53-0.96), Army 0.80 (CI: 0.67-0.96), Marines 0.96 (CI: 0.63-1.47), and Navy 0.56 (CI: 0.43-0.74).

CONCLUSION

Military deployment to GW1 was not a risk factor for developing MS.

Authors+Show Affiliations

Neurology Service, Department of Veterans Affairs (VA) Medical Center, Georgetown University School of Medicine, Washington, D.C., USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24862835

Citation

Wallin, Mitchell T., et al. "Multiple Sclerosis in Gulf War Era Veterans. 2. Military Deployment and Risk of Multiple Sclerosis in the First Gulf War." Neuroepidemiology, vol. 42, no. 4, 2014, pp. 226-34.
Wallin MT, Kurtzke JF, Culpepper WJ, et al. Multiple sclerosis in gulf war era veterans. 2. Military deployment and risk of multiple sclerosis in the first gulf war. Neuroepidemiology. 2014;42(4):226-34.
Wallin, M. T., Kurtzke, J. F., Culpepper, W. J., Coffman, P., Maloni, H., Haselkorn, J. K., & Mahan, C. M. (2014). Multiple sclerosis in gulf war era veterans. 2. Military deployment and risk of multiple sclerosis in the first gulf war. Neuroepidemiology, 42(4), pp. 226-34. doi:10.1159/000360701.
Wallin MT, et al. Multiple Sclerosis in Gulf War Era Veterans. 2. Military Deployment and Risk of Multiple Sclerosis in the First Gulf War. Neuroepidemiology. 2014;42(4):226-34. PubMed PMID: 24862835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple sclerosis in gulf war era veterans. 2. Military deployment and risk of multiple sclerosis in the first gulf war. AU - Wallin,Mitchell T, AU - Kurtzke,John F, AU - Culpepper,William J, AU - Coffman,Parisa, AU - Maloni,Heidi, AU - Haselkorn,Jodie K, AU - Mahan,Clare M, Y1 - 2014/05/25/ PY - 2013/10/21/received PY - 2014/02/19/accepted PY - 2014/5/28/entrez PY - 2014/5/28/pubmed PY - 2015/2/24/medline SP - 226 EP - 34 JF - Neuroepidemiology JO - Neuroepidemiology VL - 42 IS - 4 N2 - BACKGROUND: Concern has been raised that US veterans of the 1990-1991 Gulf War (GW1) may be at increased risk to develop neurologic disease. METHODS: An incident cohort of multiple sclerosis (MS) and other demyelinating disease (ODD) was assembled from the US military comprising the Gulf War era (1990-2007). Cases of MS and ODD meeting standard diagnostic criteria were matched to a database of all active duty personnel from the Department of Defense. Relative risk (RR) estimates for MS and all demyelinating disease based on onset, deployment status, and exposures were calculated. RESULTS: For GW1, a total of 1,841 incident cases of definite MS and ODD were identified, with 387 among 696,118 deployed and 1,454 among 1,786,215 nondeployed personnel. The RR for MS alone among those deployed compared to those nondeployed was 0.69 (confidence interval, CI: 0.61-0.78), with 0.72 (CI: 0.62-0.83) in men and 0.96 (CI: 0.75-1.22) in women. Deployment was also nonsignificant or protective as an MS risk factor across racial groups, all age groups, and each military service. RRs for MS by service were: Air Force 0.71 (CI: 0.53-0.96), Army 0.80 (CI: 0.67-0.96), Marines 0.96 (CI: 0.63-1.47), and Navy 0.56 (CI: 0.43-0.74). CONCLUSION: Military deployment to GW1 was not a risk factor for developing MS. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/24862835/Multiple_sclerosis_in_gulf_war_era_veterans__2__Military_deployment_and_risk_of_multiple_sclerosis_in_the_first_gulf_war_ L2 - https://www.karger.com?DOI=10.1159/000360701 DB - PRIME DP - Unbound Medicine ER -