Tags

Type your tag names separated by a space and hit enter

Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China.
Eur J Clin Nutr. 2014 Aug; 68(8):925-30.EJ

Abstract

BACKGROUND/OBJECTIVES

Observational studies relating 25-hydroxyvitamin D (25(OH)D) and pregnancy outcomes have reported conflicting results. The aim was to assess maternal 25(OH)D status and its association with pregnancy outcomes. A prospective observational study was carried out in Guangzhou city (23 ºN), China.

SUBJECTS/METHODS

Pregnant women (n=2960) and healthy controls (n=100) were recruited at a teaching hospital. Maternal 25(OH)D levels were measured at 16-20-week gestation. The pregnant women, if met inclusion and exclusion criteria, were enrolled in further analysis for pregnancy outcomes (n=1953).

RESULTS

Mean serum 25(OH)D in pregnant women was 27.03±7.92 ng/ml. In total, 18.9 and 48.6% of pregnant women had low (25(OH)D less than or equal to 20 ng/ml) and medium level (25(OH)D 21-29 ng/ml) of vitamin D, respectively. 25(OH)D was highest in summer and lowest in winter, which showed a positive correlation with temperature (R=0.942) and calcium (R=0.074). Most maternal outcomes (premature rupture of membranes break, polyhydramnios, oligohydramnios, pre-eclampsia, cesarean section), fetal outcomes (spontaneous abortions, medically induced labor, fetal death, fetal distress, fetal growth restriction) and neonatal outcomes (malformations, birth weight and height, low birth weight, macrosomia, small-for-gestational age, score of Apgar 1',5', asphyxia of newborn) were not significantly different between groups, but prevalence of gestational diabetes (adjusted odds ratio (OR) 1.017; 95% confidence interval (CI) 1.002-1.033) and preterm delivery (adjusted OR 1.038; 95% CI 1.018-1.059) in high level group (25(OH)D ⩾30 ng/ml) was higher than that in low and medium level groups.

CONCLUSIONS

The prevalence of low level of vitamin D (serum 25OHD ⩽20 ng/ml) was 18.9% among pregnant women in southern China. There were no significant differences in most adverse pregnancy outcomes among pregnant women with different levels of vitamin D at 16-20-week gestation except for higher prevalence of gestational diabetes and preterm delivery in women with high level of vitamin D, possibly related to the older age and higher body mass index of this group.

Authors+Show Affiliations

1] Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road 2, Guangzhou, People's Republic of China [2] Department of Endocrinology, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 108 Yanjiangxi Road, Guangzhou, People's Republic of China.Department of Geriatrics, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road 2, Guangzhou, People's Republic of China.Department of Laboratory, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road 2, Guangzhou, People's Republic of China.Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road 2, Guangzhou, People's Republic of China.Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road 2, Guangzhou, People's Republic of China.Department of Obstetrics, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road 2, Guangzhou, People's Republic of China.Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road 2, Guangzhou, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24865483

Citation

Zhou, J, et al. "Associations Between 25-hydroxyvitamin D Levels and Pregnancy Outcomes: a Prospective Observational Study in Southern China." European Journal of Clinical Nutrition, vol. 68, no. 8, 2014, pp. 925-30.
Zhou J, Su L, Liu M, et al. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. Eur J Clin Nutr. 2014;68(8):925-30.
Zhou, J., Su, L., Liu, M., Liu, Y., Cao, X., Wang, Z., & Xiao, H. (2014). Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. European Journal of Clinical Nutrition, 68(8), 925-30. https://doi.org/10.1038/ejcn.2014.99
Zhou J, et al. Associations Between 25-hydroxyvitamin D Levels and Pregnancy Outcomes: a Prospective Observational Study in Southern China. Eur J Clin Nutr. 2014;68(8):925-30. PubMed PMID: 24865483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. AU - Zhou,J, AU - Su,L, AU - Liu,M, AU - Liu,Y, AU - Cao,X, AU - Wang,Z, AU - Xiao,H, Y1 - 2014/05/28/ PY - 2013/07/19/received PY - 2014/04/10/revised PY - 2014/04/13/accepted PY - 2014/5/29/entrez PY - 2014/5/29/pubmed PY - 2015/4/8/medline SP - 925 EP - 30 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 68 IS - 8 N2 - BACKGROUND/OBJECTIVES: Observational studies relating 25-hydroxyvitamin D (25(OH)D) and pregnancy outcomes have reported conflicting results. The aim was to assess maternal 25(OH)D status and its association with pregnancy outcomes. A prospective observational study was carried out in Guangzhou city (23 ºN), China. SUBJECTS/METHODS: Pregnant women (n=2960) and healthy controls (n=100) were recruited at a teaching hospital. Maternal 25(OH)D levels were measured at 16-20-week gestation. The pregnant women, if met inclusion and exclusion criteria, were enrolled in further analysis for pregnancy outcomes (n=1953). RESULTS: Mean serum 25(OH)D in pregnant women was 27.03±7.92 ng/ml. In total, 18.9 and 48.6% of pregnant women had low (25(OH)D less than or equal to 20 ng/ml) and medium level (25(OH)D 21-29 ng/ml) of vitamin D, respectively. 25(OH)D was highest in summer and lowest in winter, which showed a positive correlation with temperature (R=0.942) and calcium (R=0.074). Most maternal outcomes (premature rupture of membranes break, polyhydramnios, oligohydramnios, pre-eclampsia, cesarean section), fetal outcomes (spontaneous abortions, medically induced labor, fetal death, fetal distress, fetal growth restriction) and neonatal outcomes (malformations, birth weight and height, low birth weight, macrosomia, small-for-gestational age, score of Apgar 1',5', asphyxia of newborn) were not significantly different between groups, but prevalence of gestational diabetes (adjusted odds ratio (OR) 1.017; 95% confidence interval (CI) 1.002-1.033) and preterm delivery (adjusted OR 1.038; 95% CI 1.018-1.059) in high level group (25(OH)D ⩾30 ng/ml) was higher than that in low and medium level groups. CONCLUSIONS: The prevalence of low level of vitamin D (serum 25OHD ⩽20 ng/ml) was 18.9% among pregnant women in southern China. There were no significant differences in most adverse pregnancy outcomes among pregnant women with different levels of vitamin D at 16-20-week gestation except for higher prevalence of gestational diabetes and preterm delivery in women with high level of vitamin D, possibly related to the older age and higher body mass index of this group. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/24865483/Associations_between_25_hydroxyvitamin_D_levels_and_pregnancy_outcomes:_a_prospective_observational_study_in_southern_China_ L2 - https://doi.org/10.1038/ejcn.2014.99 DB - PRIME DP - Unbound Medicine ER -