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Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors.
Antimicrob Agents Chemother. 2014 Aug; 58(8):4251-2.AA

Abstract

Two coronaviruses causing severe respiratory disease and high mortality rates emerging within the past dozen years reinforces the need for clinically efficacious antivirals targeting coronaviruses. Alternative screening approaches for antivirals against the recently emergent Middle East respiratory syndrome coronavirus (MERS-CoV) may provide lead compounds to address this need. Two Antimicrobial Agents and Chemotherapy (AAC) papers screened libraries of approved compounds that may potentially be repurposed as MERS-CoV antivirals. A third AAC paper showed that a previously described severe acute respiratory syndrome coronavirus (SARS-CoV) helicase inhibitor also has activity against MERS-CoV.

Authors+Show Affiliations

Editor, Antimicrobial Agents and Chemotherapy, Schwenksville, Pennsylvania, USA robert.lafemina@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24867994

Citation

LaFemina, Robert L.. "Alternative Screening Approaches for Discovery of Middle East Respiratory Syndrome Coronavirus Inhibitors." Antimicrobial Agents and Chemotherapy, vol. 58, no. 8, 2014, pp. 4251-2.
LaFemina RL. Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors. Antimicrob Agents Chemother. 2014;58(8):4251-2.
LaFemina, R. L. (2014). Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors. Antimicrobial Agents and Chemotherapy, 58(8), 4251-2. https://doi.org/10.1128/AAC.03406-14
LaFemina RL. Alternative Screening Approaches for Discovery of Middle East Respiratory Syndrome Coronavirus Inhibitors. Antimicrob Agents Chemother. 2014;58(8):4251-2. PubMed PMID: 24867994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors. A1 - LaFemina,Robert L, Y1 - 2014/05/27/ PY - 2014/5/29/entrez PY - 2014/5/29/pubmed PY - 2015/9/5/medline SP - 4251 EP - 2 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 58 IS - 8 N2 - Two coronaviruses causing severe respiratory disease and high mortality rates emerging within the past dozen years reinforces the need for clinically efficacious antivirals targeting coronaviruses. Alternative screening approaches for antivirals against the recently emergent Middle East respiratory syndrome coronavirus (MERS-CoV) may provide lead compounds to address this need. Two Antimicrobial Agents and Chemotherapy (AAC) papers screened libraries of approved compounds that may potentially be repurposed as MERS-CoV antivirals. A third AAC paper showed that a previously described severe acute respiratory syndrome coronavirus (SARS-CoV) helicase inhibitor also has activity against MERS-CoV. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/24867994/Alternative_screening_approaches_for_discovery_of_Middle_East_respiratory_syndrome_coronavirus_inhibitors_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=24867994 DB - PRIME DP - Unbound Medicine ER -