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Solitary extramedullary plasmacytoma in the gastrointestinal tract: report of two cases and review of literature.
Korean J Gastroenterol. 2014 May; 63(5):316-20.KJ

Abstract

Solitary extramedullary plasmacytoma (EMP) is a plasma cell neoplasm without bone marrow involvement. EMPs are rare in the gastrointestinal (GI) tract. We report two cases of primary EMP, one in the transverse colon and the other in the stomach. In the first case, a mass on the transverse colon was found on colonoscopy. The patient underwent left hemicolectomy and has been followed-up for 3 years without recurrence postoperatively. The latter case had several masses in the stomach. The patient underwent bypass surgery and has received supportive care for 1 month. Histopathologic specimens of both the cases showed a monoclonal lambda chain EMP. Subsequent investigations included a bone marrow biopsy, serum IgA, IgG, IgM and serum protein electrophoresis, and the results were negative for multiple myeloma in both the cases. Solitary EMP in the GI tract can be mistaken for colon cancer or stomach cancer on endoscopy; therefore, a sufficient number of biopsy specimens can help diagnose solitary EMPs. Surgical resection alone or with radiation therapy in cases with positive surgical margin is currently the only treatment for solitary EMP in the GI tract. Further study is necessary to determine disease prognosis and to investigate other treatment methods.

Authors+Show Affiliations

Division of Gastroenterology, Department of Internal Medicine, Kosin University Gospel Hospital, 262 Gamcheon-ro, Seo-gu, Busan 602-702, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

24870305

Citation

Han, You Jin, et al. "Solitary Extramedullary Plasmacytoma in the Gastrointestinal Tract: Report of Two Cases and Review of Literature." The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi, vol. 63, no. 5, 2014, pp. 316-20.
Han YJ, Park SJ, Park MI, et al. Solitary extramedullary plasmacytoma in the gastrointestinal tract: report of two cases and review of literature. Korean J Gastroenterol. 2014;63(5):316-20.
Han, Y. J., Park, S. J., Park, M. I., Moon, W., Kim, S. E., Ku, K. H., & Ock, S. Y. (2014). Solitary extramedullary plasmacytoma in the gastrointestinal tract: report of two cases and review of literature. The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi, 63(5), 316-20.
Han YJ, et al. Solitary Extramedullary Plasmacytoma in the Gastrointestinal Tract: Report of Two Cases and Review of Literature. Korean J Gastroenterol. 2014;63(5):316-20. PubMed PMID: 24870305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solitary extramedullary plasmacytoma in the gastrointestinal tract: report of two cases and review of literature. AU - Han,You Jin, AU - Park,Seun Ja, AU - Park,Moo In, AU - Moon,Won, AU - Kim,Sung Eun, AU - Ku,Ki Hwan, AU - Ock,So Young, PY - 2014/5/30/entrez PY - 2014/5/30/pubmed PY - 2016/2/20/medline SP - 316 EP - 20 JF - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi JO - Korean J Gastroenterol VL - 63 IS - 5 N2 - Solitary extramedullary plasmacytoma (EMP) is a plasma cell neoplasm without bone marrow involvement. EMPs are rare in the gastrointestinal (GI) tract. We report two cases of primary EMP, one in the transverse colon and the other in the stomach. In the first case, a mass on the transverse colon was found on colonoscopy. The patient underwent left hemicolectomy and has been followed-up for 3 years without recurrence postoperatively. The latter case had several masses in the stomach. The patient underwent bypass surgery and has received supportive care for 1 month. Histopathologic specimens of both the cases showed a monoclonal lambda chain EMP. Subsequent investigations included a bone marrow biopsy, serum IgA, IgG, IgM and serum protein electrophoresis, and the results were negative for multiple myeloma in both the cases. Solitary EMP in the GI tract can be mistaken for colon cancer or stomach cancer on endoscopy; therefore, a sufficient number of biopsy specimens can help diagnose solitary EMPs. Surgical resection alone or with radiation therapy in cases with positive surgical margin is currently the only treatment for solitary EMP in the GI tract. Further study is necessary to determine disease prognosis and to investigate other treatment methods. SN - 2233-6869 UR - https://www.unboundmedicine.com/medline/citation/24870305/Solitary_extramedullary_plasmacytoma_in_the_gastrointestinal_tract:_report_of_two_cases_and_review_of_literature_ L2 - http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2014.63.5.316 DB - PRIME DP - Unbound Medicine ER -