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Research updates in neuroimaging studies of children who stutter.

Abstract

In the past two decades, neuroimaging investigations of stuttering have led to important discoveries of structural and functional brain differences in people who stutter, providing significant clues to the neurological basis of stuttering. One major limitation, however, has been that most studies so far have only examined adults who stutter, whose brain and behavior likely would have adopted compensatory reactions to their stuttering; these confounding factors have made interpretations of the findings difficult. Developmental stuttering is a neurodevelopmental condition, and like many other neurodevelopmental disorders, stuttering is associated with an early childhood onset of symptoms and greater incidence in males relative to females. More recent studies have begun to examine children who stutter using various neuroimaging techniques that allow examination of functional neuroanatomy and interaction of major brain areas that differentiate children who stutter compared with age-matched controls. In this article, I review these more recent neuroimaging investigations of children who stutter, in the context of what we know about typical brain development, neuroplasticity, and sex differences relevant to speech and language development. Although the picture is still far from complete, these studies have potential to provide information that can be used as early objective markers, or prognostic indicators, for persistent stuttering in the future. Furthermore, these studies are the first steps in finding potential neural targets for novel therapies that may involve modulating neuroplastic growth conducive to developing and maintaining fluent speech, which can be applied to treatment of young children who stutter.

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  • Authors+Show Affiliations

    Department of Psychiatry, Child and Adolescent Psychiatry, University of Michigan, Ann Arbor, Michigan.

    Source

    Seminars in speech and language 35:2 2014 May pg 67-79

    MeSH

    Biomedical Research
    Brain
    Brain Mapping
    Child
    Dominance, Cerebral
    Electroencephalography
    Functional Neuroimaging
    Gray Matter
    Humans
    Magnetic Resonance Imaging
    Magnetoencephalography
    Neural Pathways
    Neuronal Plasticity
    Regional Blood Flow
    Sex Factors
    Spectroscopy, Near-Infrared
    Stuttering
    White Matter

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    24875668

    Citation

    Chang, Soo-Eun. "Research Updates in Neuroimaging Studies of Children Who Stutter." Seminars in Speech and Language, vol. 35, no. 2, 2014, pp. 67-79.
    Chang SE. Research updates in neuroimaging studies of children who stutter. Semin Speech Lang. 2014;35(2):67-79.
    Chang, S. E. (2014). Research updates in neuroimaging studies of children who stutter. Seminars in Speech and Language, 35(2), pp. 67-79. doi:10.1055/s-0034-1382151.
    Chang SE. Research Updates in Neuroimaging Studies of Children Who Stutter. Semin Speech Lang. 2014;35(2):67-79. PubMed PMID: 24875668.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Research updates in neuroimaging studies of children who stutter. A1 - Chang,Soo-Eun, Y1 - 2014/05/29/ PY - 2014/5/31/entrez PY - 2014/5/31/pubmed PY - 2015/1/8/medline SP - 67 EP - 79 JF - Seminars in speech and language JO - Semin Speech Lang VL - 35 IS - 2 N2 - In the past two decades, neuroimaging investigations of stuttering have led to important discoveries of structural and functional brain differences in people who stutter, providing significant clues to the neurological basis of stuttering. One major limitation, however, has been that most studies so far have only examined adults who stutter, whose brain and behavior likely would have adopted compensatory reactions to their stuttering; these confounding factors have made interpretations of the findings difficult. Developmental stuttering is a neurodevelopmental condition, and like many other neurodevelopmental disorders, stuttering is associated with an early childhood onset of symptoms and greater incidence in males relative to females. More recent studies have begun to examine children who stutter using various neuroimaging techniques that allow examination of functional neuroanatomy and interaction of major brain areas that differentiate children who stutter compared with age-matched controls. In this article, I review these more recent neuroimaging investigations of children who stutter, in the context of what we know about typical brain development, neuroplasticity, and sex differences relevant to speech and language development. Although the picture is still far from complete, these studies have potential to provide information that can be used as early objective markers, or prognostic indicators, for persistent stuttering in the future. Furthermore, these studies are the first steps in finding potential neural targets for novel therapies that may involve modulating neuroplastic growth conducive to developing and maintaining fluent speech, which can be applied to treatment of young children who stutter. SN - 1098-9056 UR - https://www.unboundmedicine.com/medline/citation/24875668/Research_updates_in_neuroimaging_studies_of_children_who_stutter_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0034-1382151 DB - PRIME DP - Unbound Medicine ER -