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Biosynthesis of silver nanoparticles using Acacia leucophloea extract and their antibacterial activity.
Int J Nanomedicine. 2014; 9:2431-8.IJ

Abstract

The immense potential of nanobiotechnology makes it an intensely researched field in modern medicine. Green nanomaterial synthesis techniques for medicinal applications are desired because of their biocompatibility and lack of toxic byproducts. We report the toxic byproducts free phytosynthesis of stable silver nanoparticles (AgNPs) using the bark extract of the traditional medicinal plant Acacia leucophloea (Fabaceae). Visual observation, ultraviolet-visible spectroscopy, and transmission electron microscopy (TEM) were used to characterize the synthesized AgNPs. The visible yellow-brown color formation and surface plasmon resonance at 440 nm indicates the biosynthesis of AgNP. The TEM images show polydisperse, mostly spherical AgNP particles of 17-29 nm. Fourier transform infrared spectroscopy revealed that primary amines, aldehyde/ketone, aromatic, azo, and nitro compounds of the A. leucophloea extract may participate in the bioreduction and capping of the formed AgNPs. X-ray diffraction confirmed the crystallinity of the AgNPs. The in vitro agar well diffusion method confirmed the potential antibacterial activity of the plant extract and synthesized AgNPs against the common bacterial pathogens Staphylococcus aureus (MTCC 737), Bacillus cereus (MTCC 1272), Listeria monocytogenes (MTCC 657), and Shigella flexneri (MTCC 1475). This research combines the inherent antimicrobial activity of silver metals with the A. leucophloea extract, yielding antibacterial activity-enhanced AgNPs. This new biomimetic approach using traditional medicinal plant (A. leucophloea) barks to synthesize biocompatible antibacterial AgNPs could easily be scaled up for additional biomedical applications. These polydisperse AgNPs green-synthesized via A. leucophloea bark extract can readily be used in many applications not requiring high uniformity in particle size or shape.

Authors+Show Affiliations

Department of Microbiology and Botany, College of Science, King Saud University, Riyadh, Saudi Arabia.Department of Biotechnology, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, India ; Department of Medical Microbiology, School of Medicine, Health and Medical Science College, Haramaya University, Harar, Ethiopia.Department of Biotechnology, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, India.Department of Microbiology and Botany, College of Science, King Saud University, Riyadh, Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24876776

Citation

Murugan, Kasi, et al. "Biosynthesis of Silver Nanoparticles Using Acacia Leucophloea Extract and Their Antibacterial Activity." International Journal of Nanomedicine, vol. 9, 2014, pp. 2431-8.
Murugan K, Senthilkumar B, Senbagam D, et al. Biosynthesis of silver nanoparticles using Acacia leucophloea extract and their antibacterial activity. Int J Nanomedicine. 2014;9:2431-8.
Murugan, K., Senthilkumar, B., Senbagam, D., & Al-Sohaibani, S. (2014). Biosynthesis of silver nanoparticles using Acacia leucophloea extract and their antibacterial activity. International Journal of Nanomedicine, 9, 2431-8. https://doi.org/10.2147/IJN.S61779
Murugan K, et al. Biosynthesis of Silver Nanoparticles Using Acacia Leucophloea Extract and Their Antibacterial Activity. Int J Nanomedicine. 2014;9:2431-8. PubMed PMID: 24876776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biosynthesis of silver nanoparticles using Acacia leucophloea extract and their antibacterial activity. AU - Murugan,Kasi, AU - Senthilkumar,Balakrishnan, AU - Senbagam,Duraisamy, AU - Al-Sohaibani,Saleh, Y1 - 2014/05/15/ PY - 2014/5/31/entrez PY - 2014/5/31/pubmed PY - 2014/12/15/medline KW - Acacia leucophloea KW - AgNPs KW - FTIR KW - TEM KW - XRD KW - antibacterial activity KW - biogenic SP - 2431 EP - 8 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 9 N2 - The immense potential of nanobiotechnology makes it an intensely researched field in modern medicine. Green nanomaterial synthesis techniques for medicinal applications are desired because of their biocompatibility and lack of toxic byproducts. We report the toxic byproducts free phytosynthesis of stable silver nanoparticles (AgNPs) using the bark extract of the traditional medicinal plant Acacia leucophloea (Fabaceae). Visual observation, ultraviolet-visible spectroscopy, and transmission electron microscopy (TEM) were used to characterize the synthesized AgNPs. The visible yellow-brown color formation and surface plasmon resonance at 440 nm indicates the biosynthesis of AgNP. The TEM images show polydisperse, mostly spherical AgNP particles of 17-29 nm. Fourier transform infrared spectroscopy revealed that primary amines, aldehyde/ketone, aromatic, azo, and nitro compounds of the A. leucophloea extract may participate in the bioreduction and capping of the formed AgNPs. X-ray diffraction confirmed the crystallinity of the AgNPs. The in vitro agar well diffusion method confirmed the potential antibacterial activity of the plant extract and synthesized AgNPs against the common bacterial pathogens Staphylococcus aureus (MTCC 737), Bacillus cereus (MTCC 1272), Listeria monocytogenes (MTCC 657), and Shigella flexneri (MTCC 1475). This research combines the inherent antimicrobial activity of silver metals with the A. leucophloea extract, yielding antibacterial activity-enhanced AgNPs. This new biomimetic approach using traditional medicinal plant (A. leucophloea) barks to synthesize biocompatible antibacterial AgNPs could easily be scaled up for additional biomedical applications. These polydisperse AgNPs green-synthesized via A. leucophloea bark extract can readily be used in many applications not requiring high uniformity in particle size or shape. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/24876776/Biosynthesis_of_silver_nanoparticles_using_Acacia_leucophloea_extract_and_their_antibacterial_activity_ L2 - https://dx.doi.org/10.2147/IJN.S61779 DB - PRIME DP - Unbound Medicine ER -