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The association among antioxidant enzymes, autoantibodies, and disease severity score in systemic lupus erythematosus: comparison of neuropsychiatric and nonneuropsychiatric groups.

Abstract

BACKGROUND

Antioxidative capacity plays an important role in the severity of systemic lupus erythematosus (SLE), which is characterized by autoantibodies. This study aimed to determine the relationship among autoantibody titers, antioxidative stress reserve, and severity of SLE.

METHODS

The autoantibody titers, clinical markers, antioxidant enzyme levels, and disease activity index (SLEDAI-2k) of 32 SLE patients and 16 healthy controls were compared. We also compared both the neuropsychiatric (NPSLE) and nonneuropsychiatric (non-NPSLE) groups.

RESULTS

Superoxide dismutase in red blood cells was significantly lower in the SLE than in the control group. CRP levels are significant higher in SLE patients than in control group (P = 0.034). Among the autoantibodies, anti-U1RNP (P = 0.008), a-Sm (P = 0.027), and anti-ribosomal p (P = 0.028) significantly negatively correlated with glutathione levels. There has no significant correlation between SLE disease activity indexes (SLEDAI) and levels of C3, C4, and antioxidant enzymes.

CONCLUSIONS

Erythrocyte superoxide dismutase is significantly lower in both NPSLE and non-NPSLE groups. SLE patients have both higher CRP and autoantibodies level and decreased superoxide dismutase level than the healthy control group.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan ; Department of Biological Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.

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    Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

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    Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

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    Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

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    Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

    ,

    Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

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    Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

    ,

    Department of Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

    ,

    Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

    ,

    Department of Biological Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan ; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

    ,

    Department of Biological Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan ; Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

    ,

    Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

    ,

    Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan ; Department of Biological Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.

    Department of Biological Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan ; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

    Source

    BioMed research international 2014: 2014 pg 137231

    MeSH

    Adult
    Antioxidants
    Autoantibodies
    Erythrocytes
    Female
    Glutathione
    Humans
    Lupus Erythematosus, Systemic
    Male
    Mental Disorders
    Middle Aged
    Nervous System Diseases
    Prospective Studies
    Superoxide Dismutase

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24877055

    Citation

    Su, Yu-Jih, et al. "The Association Among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus: Comparison of Neuropsychiatric and Nonneuropsychiatric Groups." BioMed Research International, vol. 2014, 2014, p. 137231.
    Su YJ, Cheng TT, Chen CJ, et al. The association among antioxidant enzymes, autoantibodies, and disease severity score in systemic lupus erythematosus: comparison of neuropsychiatric and nonneuropsychiatric groups. Biomed Res Int. 2014;2014:137231.
    Su, Y. J., Cheng, T. T., Chen, C. J., Chiu, W. C., Chang, W. N., Tsai, N. W., ... Lu, C. H. (2014). The association among antioxidant enzymes, autoantibodies, and disease severity score in systemic lupus erythematosus: comparison of neuropsychiatric and nonneuropsychiatric groups. BioMed Research International, 2014, p. 137231. doi:10.1155/2014/137231.
    Su YJ, et al. The Association Among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus: Comparison of Neuropsychiatric and Nonneuropsychiatric Groups. Biomed Res Int. 2014;2014:137231. PubMed PMID: 24877055.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The association among antioxidant enzymes, autoantibodies, and disease severity score in systemic lupus erythematosus: comparison of neuropsychiatric and nonneuropsychiatric groups. AU - Su,Yu-Jih, AU - Cheng,Tien-Tsai, AU - Chen,Chung-Jen, AU - Chiu,Wen-Chan, AU - Chang,Wen-Neng, AU - Tsai,Nai-Wen, AU - Kung,Chia-Te, AU - Lin,Wei-Che, AU - Huang,Chih-Cheng, AU - Chang,Ya-Ting, AU - Su,Chih-Min, AU - Chiang,Yi-Fang, AU - Cheng,Ben-Chung, AU - Lu,Cheng-Hsien, Y1 - 2014/04/27/ PY - 2014/02/25/received PY - 2014/04/01/accepted PY - 2014/5/31/entrez PY - 2014/5/31/pubmed PY - 2015/2/13/medline SP - 137231 EP - 137231 JF - BioMed research international JO - Biomed Res Int VL - 2014 N2 - BACKGROUND: Antioxidative capacity plays an important role in the severity of systemic lupus erythematosus (SLE), which is characterized by autoantibodies. This study aimed to determine the relationship among autoantibody titers, antioxidative stress reserve, and severity of SLE. METHODS: The autoantibody titers, clinical markers, antioxidant enzyme levels, and disease activity index (SLEDAI-2k) of 32 SLE patients and 16 healthy controls were compared. We also compared both the neuropsychiatric (NPSLE) and nonneuropsychiatric (non-NPSLE) groups. RESULTS: Superoxide dismutase in red blood cells was significantly lower in the SLE than in the control group. CRP levels are significant higher in SLE patients than in control group (P = 0.034). Among the autoantibodies, anti-U1RNP (P = 0.008), a-Sm (P = 0.027), and anti-ribosomal p (P = 0.028) significantly negatively correlated with glutathione levels. There has no significant correlation between SLE disease activity indexes (SLEDAI) and levels of C3, C4, and antioxidant enzymes. CONCLUSIONS: Erythrocyte superoxide dismutase is significantly lower in both NPSLE and non-NPSLE groups. SLE patients have both higher CRP and autoantibodies level and decreased superoxide dismutase level than the healthy control group. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/24877055/full_citation L2 - https://dx.doi.org/10.1155/2014/137231 DB - PRIME DP - Unbound Medicine ER -