Inflammation based regulation of cancer cachexia.
Cancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and quality of life outcomes. This review summarizes the clinical implications, background of inflammatory cytokines, and the origin and sources of procachectic factors including TNF-α, IL-6, IL-1, INF-γ, and PIF. Molecular mechanisms and pathways are described to elucidate the link between the immune response caused by the presence of the tumor and the final result of skeletal muscle wasting.
Division of Surgical Oncology, The Ohio State University Wexner Medical Center, The Ohio State University College of Medicine, 460 W. 12th Avenue, Columbus, OH 43210, USA ; The Arthur G. James Comprehensive Cancer Center, Columbus, OH 43210, USA.
The Arthur G. James Comprehensive Cancer Center, Columbus, OH 43210, USA ; Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.
Pub Type(s)Journal Article