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Inflammation based regulation of cancer cachexia.

Abstract

Cancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and quality of life outcomes. This review summarizes the clinical implications, background of inflammatory cytokines, and the origin and sources of procachectic factors including TNF-α, IL-6, IL-1, INF-γ, and PIF. Molecular mechanisms and pathways are described to elucidate the link between the immune response caused by the presence of the tumor and the final result of skeletal muscle wasting.

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  • Authors+Show Affiliations

    ,

    Division of Surgical Oncology, The Ohio State University Wexner Medical Center, The Ohio State University College of Medicine, 460 W. 12th Avenue, Columbus, OH 43210, USA ; The Arthur G. James Comprehensive Cancer Center, Columbus, OH 43210, USA.

    The Arthur G. James Comprehensive Cancer Center, Columbus, OH 43210, USA ; Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.

    Source

    BioMed research international 2014: 2014 pg 168407

    MeSH

    Animals
    Cachexia
    Cytokines
    Humans
    Inflammation
    Muscle, Skeletal
    Neoplasms
    Wasting Syndrome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    24877061

    Citation

    Onesti, Jill K., and Denis C. Guttridge. "Inflammation Based Regulation of Cancer Cachexia." BioMed Research International, vol. 2014, 2014, p. 168407.
    Onesti JK, Guttridge DC. Inflammation based regulation of cancer cachexia. Biomed Res Int. 2014;2014:168407.
    Onesti, J. K., & Guttridge, D. C. (2014). Inflammation based regulation of cancer cachexia. BioMed Research International, 2014, p. 168407. doi:10.1155/2014/168407.
    Onesti JK, Guttridge DC. Inflammation Based Regulation of Cancer Cachexia. Biomed Res Int. 2014;2014:168407. PubMed PMID: 24877061.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Inflammation based regulation of cancer cachexia. AU - Onesti,Jill K, AU - Guttridge,Denis C, Y1 - 2014/05/04/ PY - 2014/02/13/received PY - 2014/04/10/accepted PY - 2014/5/31/entrez PY - 2014/5/31/pubmed PY - 2015/2/13/medline SP - 168407 EP - 168407 JF - BioMed research international JO - Biomed Res Int VL - 2014 N2 - Cancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and quality of life outcomes. This review summarizes the clinical implications, background of inflammatory cytokines, and the origin and sources of procachectic factors including TNF-α, IL-6, IL-1, INF-γ, and PIF. Molecular mechanisms and pathways are described to elucidate the link between the immune response caused by the presence of the tumor and the final result of skeletal muscle wasting. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/24877061/full_citation L2 - https://dx.doi.org/10.1155/2014/168407 DB - PRIME DP - Unbound Medicine ER -