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Rural residents in China are at increased risk of exposure to tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis.
Biomed Res Int. 2014; 2014:313867.BR

Abstract

As emerging tick born rickettsial diseases caused by A. phagocytophilum and E. chaffeensis, anaplasmosis and ehrlichiosis have become a serious threat to human and animal health throughout the world. In particular, in China, an unusual transmission of nosocomial cases of human granulocytic anaplasmosis occurred in Anhui Province in 2006 and more recent coinfection case of A. phagocytophilum and E. chaffeensis was documented in Shandong Province. Although the seroprevalence of human granulocytic anaplasmosis (former human granulocytic ehrlichiosis, HGE) has been documented in several studies, these data existed on local investigations, and also little data was reported on the seroprevalence of human monocytic ehrlichiosis (HME) in China. In this cross-sectional epidemiological study, indirect immunofluorescence antibody assay (IFA) proposed by WHO was used to detect A. phagocytophilum and E. chaffeensis IgG antibodies for 7,322 serum samples from agrarian residents from 9 provinces/cities and 819 urban residents from 2 provinces. Our data showed that farmers were at substantially increased risk of exposure. However, even among urban residents, risk was considerable. Seroprevalence of HGA and HME occurred in diverse regions of the country and tended to be the highest in young adults. Many species of ticks were confirmed carrying A. phagocytophilum organisms in China while several kinds of domestic animals including dog, goats, sheep, cattle, horse, wild rabbit, and some small wild rodents were proposed to be the reservoir hosts of A. phagocytophilum. The broad distribution of vector and hosts of the A. phagocytophilum and E. chaffeensis, especially the relationship between the generalized susceptibility of vectors and reservoirs and the severity of the disease's clinical manifestations and the genetic variation of Chinese HGA isolates in China, is urgently needed to be further investigated.

Authors+Show Affiliations

Department of Rickettsiology, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing 102206, China.Centers for Disease Control and Prevention of Anhui Province, Hefei 650022, China.Centers for Disease Control and Prevention of Henan Province, Zhengzhou 450016, China.Tianjin Center for Disease Control and Prevention, Beijing 300011, China.Centers for Disease Control and Prevention of Hainan Province, Haikou 570203, China.Centers for Disease Control and Prevention of Jilin Province, Changchun 130062, China.Centers for Disease Control and Prevention of Zhejiang Province, Hangzhou 310051, China.Centers for Disease Control and Prevention of Jiangsu Province, Nanjing 210009, China.Centers for Disease Control and Prevention of Yunnan Province, Kunming 650022, China.Beijing Center for Disease Control and Prevention, Beijing 100013, China.YiLi Prefecture Center for Disease Control and Prevention, Yili 835000, China.Centers for Disease Control and Prevention of Anhui Province, Hefei 650022, China.Centers for Disease Control and Prevention of Henan Province, Zhengzhou 450016, China.Tianjin Center for Disease Control and Prevention, Beijing 300011, China.Beijing Center for Disease Control and Prevention, Beijing 100013, China.Department of Rickettsiology, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing 102206, China.Department of Rickettsiology, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing 102206, China.Department of Rickettsiology, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing 102206, China.Department of Rickettsiology, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing 102206, China.Department of Rickettsiology, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing 102206, China ; Shihezi University, Shihezi 832000, China.Department of Rickettsiology, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing 102206, China ; Shihezi University, Shihezi 832000, China.Centers for Disease Control and Prevention of Anhui Province, Hefei 650022, China.Centers for Disease Control and Prevention of Henan Province, Zhengzhou 450016, China.Tianjin Center for Disease Control and Prevention, Beijing 300011, China.Centers for Disease Control and Prevention of Hainan Province, Haikou 570203, China.Centers for Disease Control and Prevention of Jiangsu Province, Nanjing 210009, China.Centers for Disease Control and Prevention of Yunnan Province, Kunming 650022, China.Beijing Center for Disease Control and Prevention, Beijing 100013, China.YiLi Prefecture Center for Disease Control and Prevention, Yili 835000, China.Centers for Disease Control and Prevention of Anhui Province, Hefei 650022, China.Centers for Disease Control and Prevention of Hainan Province, Haikou 570203, China.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24877080

Citation

Zhang, Lijuan, et al. "Rural Residents in China Are at Increased Risk of Exposure to Tick-borne Pathogens Anaplasma Phagocytophilum and Ehrlichia Chaffeensis." BioMed Research International, vol. 2014, 2014, p. 313867.
Zhang L, Liu H, Xu B, et al. Rural residents in China are at increased risk of exposure to tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. Biomed Res Int. 2014;2014:313867.
Zhang, L., Liu, H., Xu, B., Zhang, Z., Jin, Y., Li, W., Lu, Q., Li, L., Chang, L., Zhang, X., Fan, D., Cao, M., Bao, M., Zhang, Y., Guan, Z., Cheng, X., Tian, L., Wang, S., Yu, H., ... Huang, F. (2014). Rural residents in China are at increased risk of exposure to tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. BioMed Research International, 2014, 313867. https://doi.org/10.1155/2014/313867
Zhang L, et al. Rural Residents in China Are at Increased Risk of Exposure to Tick-borne Pathogens Anaplasma Phagocytophilum and Ehrlichia Chaffeensis. Biomed Res Int. 2014;2014:313867. PubMed PMID: 24877080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rural residents in China are at increased risk of exposure to tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. AU - Zhang,Lijuan, AU - Liu,Hong, AU - Xu,Bianli, AU - Zhang,Zhilun, AU - Jin,Yuming, AU - Li,Weiming, AU - Lu,Qunying, AU - Li,Liang, AU - Chang,Litao, AU - Zhang,Xiuchun, AU - Fan,Desheng, AU - Cao,Minghua, AU - Bao,Manli, AU - Zhang,Ying, AU - Guan,Zengzhi, AU - Cheng,Xueqin, AU - Tian,Lina, AU - Wang,Shiwen, AU - Yu,Huilan, AU - Yu,Qiang, AU - Wang,Yong, AU - Zhang,Yonggen, AU - Tang,Xiaoyan, AU - Yin,Jieying, AU - Lao,Shijun, AU - Wu,Bin, AU - Li,Juan, AU - Li,Weihong, AU - Xu,Qiyi, AU - Shi,Yonglin, AU - Huang,Fang, Y1 - 2014/04/30/ PY - 2014/02/05/received PY - 2014/03/07/accepted PY - 2014/5/31/entrez PY - 2014/5/31/pubmed PY - 2015/2/13/medline SP - 313867 EP - 313867 JF - BioMed research international JO - Biomed Res Int VL - 2014 N2 - As emerging tick born rickettsial diseases caused by A. phagocytophilum and E. chaffeensis, anaplasmosis and ehrlichiosis have become a serious threat to human and animal health throughout the world. In particular, in China, an unusual transmission of nosocomial cases of human granulocytic anaplasmosis occurred in Anhui Province in 2006 and more recent coinfection case of A. phagocytophilum and E. chaffeensis was documented in Shandong Province. Although the seroprevalence of human granulocytic anaplasmosis (former human granulocytic ehrlichiosis, HGE) has been documented in several studies, these data existed on local investigations, and also little data was reported on the seroprevalence of human monocytic ehrlichiosis (HME) in China. In this cross-sectional epidemiological study, indirect immunofluorescence antibody assay (IFA) proposed by WHO was used to detect A. phagocytophilum and E. chaffeensis IgG antibodies for 7,322 serum samples from agrarian residents from 9 provinces/cities and 819 urban residents from 2 provinces. Our data showed that farmers were at substantially increased risk of exposure. However, even among urban residents, risk was considerable. Seroprevalence of HGA and HME occurred in diverse regions of the country and tended to be the highest in young adults. Many species of ticks were confirmed carrying A. phagocytophilum organisms in China while several kinds of domestic animals including dog, goats, sheep, cattle, horse, wild rabbit, and some small wild rodents were proposed to be the reservoir hosts of A. phagocytophilum. The broad distribution of vector and hosts of the A. phagocytophilum and E. chaffeensis, especially the relationship between the generalized susceptibility of vectors and reservoirs and the severity of the disease's clinical manifestations and the genetic variation of Chinese HGA isolates in China, is urgently needed to be further investigated. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/24877080/Rural_residents_in_China_are_at_increased_risk_of_exposure_to_tick_borne_pathogens_Anaplasma_phagocytophilum_and_Ehrlichia_chaffeensis_ L2 - https://dx.doi.org/10.1155/2014/313867 DB - PRIME DP - Unbound Medicine ER -