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Effect of whole soy and purified isoflavone daidzein on renal function--a 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension.
Clin Biochem 2014; 47(13-14):1250-6CB

Abstract

OBJECTIVES

The aim of the study was to examine the long-term effect of commonly used whole soy foods (soy flour) and purified daidzein (one major isoflavone and the precursor of equol) on renal function among prehypertensive postmenopausal women who are also equol producers, a population most likely to benefit from soy intervention.

DESIGN AND METHODS

This was a 6-month double-blind, randomized, placebo-controlled trial. Two hundred seventy eligible Chinese women were randomized to either one of the three treatments: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group) or 40 g low-fat milk powder (placebo group) daily each for 6 months. Fasting blood and 24-h urine samples were collected at the beginning and end of trial. Serum creatinine, cystatin C, urea, angiotensin-converting enzyme, minerals and 24-h urinary creatinine and minerals were analyzed. Estimated glomerular filtration rate (eGFR) was calculated with the Cockcroft-Gault and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations.

RESULTS

Two hundred fifty-three subjects completed the study according to the protocol. Urinary isoflavones indicated good compliance of participants. No significant changes were observed in most of renal parameters, however, there was a less decrease in eGFRcockcroft in 6-month change (p=0.044) and %change (p=0.031) with whole soy intake relative to milk placebo. Subgroup analysis among women with lowered renal function suggested whole soy consumption tended to improve markers of renal function relative to control.

CONCLUSIONS

Six-month consumption of whole soy tended to have a modest improvement of renal function in prehypertensive postmenopausal women with lowered renal function. Future trials in subjects with more declined renal function are necessary.

TRIAL REGISTRATION

The trial was registered in ClinicalTrials.gov with identifier of NCT01270737. (URL: http://clinicaltrials.gov/ct2/show/NCT01270737).

Authors+Show Affiliations

Department of Medicine &Therapeutics, the Chinese University of Hong Kong, Hong Kong SAR.Division of Epidemiology, The Jockey Club School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR. Electronic address: suzanneho@cuhk.edu.hk.Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, PR China.Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR.Department of Medicine &Therapeutics, the Chinese University of Hong Kong, Hong Kong SAR. Electronic address: jeanwoowong@cuhk.edu.hk.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24877660

Citation

Liu, Zhao-min, et al. "Effect of Whole Soy and Purified Isoflavone Daidzein On Renal Function--a 6-month Randomized Controlled Trial in Equol-producing Postmenopausal Women With Prehypertension." Clinical Biochemistry, vol. 47, no. 13-14, 2014, pp. 1250-6.
Liu ZM, Ho SC, Chen YM, et al. Effect of whole soy and purified isoflavone daidzein on renal function--a 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension. Clin Biochem. 2014;47(13-14):1250-6.
Liu, Z. M., Ho, S. C., Chen, Y. M., Tang, N., & Woo, J. (2014). Effect of whole soy and purified isoflavone daidzein on renal function--a 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension. Clinical Biochemistry, 47(13-14), pp. 1250-6. doi:10.1016/j.clinbiochem.2014.05.054.
Liu ZM, et al. Effect of Whole Soy and Purified Isoflavone Daidzein On Renal Function--a 6-month Randomized Controlled Trial in Equol-producing Postmenopausal Women With Prehypertension. Clin Biochem. 2014;47(13-14):1250-6. PubMed PMID: 24877660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of whole soy and purified isoflavone daidzein on renal function--a 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension. AU - Liu,Zhao-min, AU - Ho,Suzanne C, AU - Chen,Yu-ming, AU - Tang,Nelson, AU - Woo,Jean, Y1 - 2014/05/27/ PY - 2014/04/18/received PY - 2014/05/14/revised PY - 2014/05/15/accepted PY - 2014/6/1/entrez PY - 2014/6/1/pubmed PY - 2015/5/13/medline KW - Daidzein KW - Equol producers KW - Prehypertension KW - Renal function KW - Whole soy SP - 1250 EP - 6 JF - Clinical biochemistry JO - Clin. Biochem. VL - 47 IS - 13-14 N2 - OBJECTIVES: The aim of the study was to examine the long-term effect of commonly used whole soy foods (soy flour) and purified daidzein (one major isoflavone and the precursor of equol) on renal function among prehypertensive postmenopausal women who are also equol producers, a population most likely to benefit from soy intervention. DESIGN AND METHODS: This was a 6-month double-blind, randomized, placebo-controlled trial. Two hundred seventy eligible Chinese women were randomized to either one of the three treatments: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group) or 40 g low-fat milk powder (placebo group) daily each for 6 months. Fasting blood and 24-h urine samples were collected at the beginning and end of trial. Serum creatinine, cystatin C, urea, angiotensin-converting enzyme, minerals and 24-h urinary creatinine and minerals were analyzed. Estimated glomerular filtration rate (eGFR) was calculated with the Cockcroft-Gault and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. RESULTS: Two hundred fifty-three subjects completed the study according to the protocol. Urinary isoflavones indicated good compliance of participants. No significant changes were observed in most of renal parameters, however, there was a less decrease in eGFRcockcroft in 6-month change (p=0.044) and %change (p=0.031) with whole soy intake relative to milk placebo. Subgroup analysis among women with lowered renal function suggested whole soy consumption tended to improve markers of renal function relative to control. CONCLUSIONS: Six-month consumption of whole soy tended to have a modest improvement of renal function in prehypertensive postmenopausal women with lowered renal function. Future trials in subjects with more declined renal function are necessary. TRIAL REGISTRATION: The trial was registered in ClinicalTrials.gov with identifier of NCT01270737. (URL: http://clinicaltrials.gov/ct2/show/NCT01270737). SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/24877660/Effect_of_whole_soy_and_purified_isoflavone_daidzein_on_renal_function__a_6_month_randomized_controlled_trial_in_equol_producing_postmenopausal_women_with_prehypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(14)00282-3 DB - PRIME DP - Unbound Medicine ER -