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Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women.
J Clin Endocrinol Metab. 2014 Sep; 99(9):E1666-70.JC

Abstract

CONTEXT

The mechanism(s) responsible for diurnal variations in insulin sensitivity of glucose metabolism in healthy people are unclear.

OBJECTIVE

The objective of the study was to evaluate whether diurnal variations in whole-body and cellular fatty acid metabolism could contribute to evening insulin resistance in metabolically normal people.

SUBJECTS AND DESIGN

We measured plasma the free fatty acid (FFA) concentration, palmitate kinetics, and skeletal muscle expression of genes involved in fatty acid metabolism at breakfast (7:00 am) and dinner (7:00 pm) in 13 overweight (body mass index 27.8 ± 1.2 kg/m(2)) but metabolically normal, women.

RESULTS

Plasma FFA concentration was approximately 30% greater just before consuming dinner than breakfast (P < .05) and remained greater after dinner than breakfast (FFA areas under the curve: 0.88 ± 0.33 and 0.51 ± 0.09 μmol/mL × 4 h, P = .001). However, adipose tissue lipolytic activity was not different in the evening and in the morning. Skeletal muscle expression of genes that regulate fatty acid oxidation were 38-82% lower, whereas genes involved in de novo lipogenesis were 51%-87 % higher before dinner than before breakfast (all P < .05), and these changes were associated with diurnal variation in the muscle expression of core clock genes that regulate fatty acid metabolism.

CONCLUSION

Metabolically normal women demonstrate diurnal variations in fatty acid metabolism, manifested by an increase in circulating FFAs, presumably derived from previous meal consumption rather than lipolysis of adipose tissue triglycerides, and a shift in muscle fatty acid metabolism from oxidation to lipogenesis. These metabolic alterations could be responsible for the known evening decline in insulin sensitivity.

Authors+Show Affiliations

Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine (J.Y., P.A.-V., B.W.P., A.L.O., S.I., B.M., S.K.) and Department of Developmental Biology (S.I.), Washington University School of Medicine, St Louis, Missouri 63110.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24878055

Citation

Yoshino, Jun, et al. "Diurnal Variation in Insulin Sensitivity of Glucose Metabolism Is Associated With Diurnal Variations in Whole-body and Cellular Fatty Acid Metabolism in Metabolically Normal Women." The Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 9, 2014, pp. E1666-70.
Yoshino J, Almeda-Valdes P, Patterson BW, et al. Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. J Clin Endocrinol Metab. 2014;99(9):E1666-70.
Yoshino, J., Almeda-Valdes, P., Patterson, B. W., Okunade, A. L., Imai, S., Mittendorfer, B., & Klein, S. (2014). Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. The Journal of Clinical Endocrinology and Metabolism, 99(9), E1666-70. https://doi.org/10.1210/jc.2014-1579
Yoshino J, et al. Diurnal Variation in Insulin Sensitivity of Glucose Metabolism Is Associated With Diurnal Variations in Whole-body and Cellular Fatty Acid Metabolism in Metabolically Normal Women. J Clin Endocrinol Metab. 2014;99(9):E1666-70. PubMed PMID: 24878055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. AU - Yoshino,Jun, AU - Almeda-Valdes,Paloma, AU - Patterson,Bruce W, AU - Okunade,Adewole L, AU - Imai,Shin-ichiro, AU - Mittendorfer,Bettina, AU - Klein,Samuel, Y1 - 2014/05/30/ PY - 2014/6/1/entrez PY - 2014/6/1/pubmed PY - 2015/1/13/medline SP - E1666 EP - 70 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 99 IS - 9 N2 - CONTEXT: The mechanism(s) responsible for diurnal variations in insulin sensitivity of glucose metabolism in healthy people are unclear. OBJECTIVE: The objective of the study was to evaluate whether diurnal variations in whole-body and cellular fatty acid metabolism could contribute to evening insulin resistance in metabolically normal people. SUBJECTS AND DESIGN: We measured plasma the free fatty acid (FFA) concentration, palmitate kinetics, and skeletal muscle expression of genes involved in fatty acid metabolism at breakfast (7:00 am) and dinner (7:00 pm) in 13 overweight (body mass index 27.8 ± 1.2 kg/m(2)) but metabolically normal, women. RESULTS: Plasma FFA concentration was approximately 30% greater just before consuming dinner than breakfast (P < .05) and remained greater after dinner than breakfast (FFA areas under the curve: 0.88 ± 0.33 and 0.51 ± 0.09 μmol/mL × 4 h, P = .001). However, adipose tissue lipolytic activity was not different in the evening and in the morning. Skeletal muscle expression of genes that regulate fatty acid oxidation were 38-82% lower, whereas genes involved in de novo lipogenesis were 51%-87 % higher before dinner than before breakfast (all P < .05), and these changes were associated with diurnal variation in the muscle expression of core clock genes that regulate fatty acid metabolism. CONCLUSION: Metabolically normal women demonstrate diurnal variations in fatty acid metabolism, manifested by an increase in circulating FFAs, presumably derived from previous meal consumption rather than lipolysis of adipose tissue triglycerides, and a shift in muscle fatty acid metabolism from oxidation to lipogenesis. These metabolic alterations could be responsible for the known evening decline in insulin sensitivity. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/24878055/Diurnal_variation_in_insulin_sensitivity_of_glucose_metabolism_is_associated_with_diurnal_variations_in_whole_body_and_cellular_fatty_acid_metabolism_in_metabolically_normal_women_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2014-1579 DB - PRIME DP - Unbound Medicine ER -