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The effect of exercise on hippocampal volume and neurotrophines in patients with major depression--a randomized clinical trial.
J Affect Disord. 2014 Aug; 165:24-30.JA

Abstract

BACKGROUND

The hippocampal volume is reduced in patients with major depression. Exercise leads to an increased hippocampal volume in schizophrenia and in healthy old adults. The effect of exercise on hippocampal volume is potentially mediated by brain derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin like growth factor 1 (IGF-1). The aim of this trial was to assess the effect of an aerobic exercise intervention on hippocampal volume and serum BDNF, VEGF, and IGF-1 in patients with major depression.

METHODS

Patients were randomized to an aerobic exercise intervention (n=41) or a control condition (n=38). Both interventions consisted of three supervised sessions per week during a three months period.

RESULTS

Post-intervention the increase in maximal oxygen uptake was 3.90 ml/kg/min (SD 5.1) in the aerobic exercise group and 0.95 ml/kg/min (SD 6.2) in the control group (p=0.03). The hippocampal volume, BDNF, VEGF, or IGF-1 did not differ between the two groups. Post-hoc we found a positive association between change in hippocampal volume and verbal memory (Rho=0.27; p=0.05) and change in hippocampal volume and depressive symptoms (Rho=0.30; p=0.03).

LIMITATIONS

Participation was low in both groups corresponding to an average participation of one session per week.

CONCLUSION

Despite a significant increase in maximal oxygen uptake, a pragmatic exercise intervention did not increase hippocampal volume or resting levels of neurotrophines in out-patients with mild to moderate major depression. Trial identifier: ClinicalTrials.gov (NCT00695552).

Authors+Show Affiliations

Mental Health Centre Copenhagen, Mental Health Services in the Capital Region of Denmark, University of Copenhagen, Copenhagen, Denmark. Electronic address: Jesper.krogh@regionh.dk.Functional Imaging Unit, Department of Diagnostics, Copenhagen University Hospital, Glostrup Hospital, Denmark.Department of Radiology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.Department for Depression and Anxiety Q, Aarhus University Hospital, Risskov, Denmark.Mental Health Centre Copenhagen, Mental Health Services in the Capital Region of Denmark, University of Copenhagen, Copenhagen, Denmark.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24882173

Citation

Krogh, Jesper, et al. "The Effect of Exercise On Hippocampal Volume and Neurotrophines in Patients With Major Depression--a Randomized Clinical Trial." Journal of Affective Disorders, vol. 165, 2014, pp. 24-30.
Krogh J, Rostrup E, Thomsen C, et al. The effect of exercise on hippocampal volume and neurotrophines in patients with major depression--a randomized clinical trial. J Affect Disord. 2014;165:24-30.
Krogh, J., Rostrup, E., Thomsen, C., Elfving, B., Videbech, P., & Nordentoft, M. (2014). The effect of exercise on hippocampal volume and neurotrophines in patients with major depression--a randomized clinical trial. Journal of Affective Disorders, 165, 24-30. https://doi.org/10.1016/j.jad.2014.04.041
Krogh J, et al. The Effect of Exercise On Hippocampal Volume and Neurotrophines in Patients With Major Depression--a Randomized Clinical Trial. J Affect Disord. 2014;165:24-30. PubMed PMID: 24882173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of exercise on hippocampal volume and neurotrophines in patients with major depression--a randomized clinical trial. AU - Krogh,Jesper, AU - Rostrup,Egill, AU - Thomsen,Carsten, AU - Elfving,Betina, AU - Videbech,Poul, AU - Nordentoft,Merete, Y1 - 2014/04/23/ PY - 2014/01/04/received PY - 2014/04/15/revised PY - 2014/04/15/accepted PY - 2014/6/3/entrez PY - 2014/6/3/pubmed PY - 2014/12/15/medline KW - BDNF KW - Depression KW - Exercise KW - Hippocampus KW - Memory KW - Neurogenesis SP - 24 EP - 30 JF - Journal of affective disorders JO - J Affect Disord VL - 165 N2 - BACKGROUND: The hippocampal volume is reduced in patients with major depression. Exercise leads to an increased hippocampal volume in schizophrenia and in healthy old adults. The effect of exercise on hippocampal volume is potentially mediated by brain derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin like growth factor 1 (IGF-1). The aim of this trial was to assess the effect of an aerobic exercise intervention on hippocampal volume and serum BDNF, VEGF, and IGF-1 in patients with major depression. METHODS: Patients were randomized to an aerobic exercise intervention (n=41) or a control condition (n=38). Both interventions consisted of three supervised sessions per week during a three months period. RESULTS: Post-intervention the increase in maximal oxygen uptake was 3.90 ml/kg/min (SD 5.1) in the aerobic exercise group and 0.95 ml/kg/min (SD 6.2) in the control group (p=0.03). The hippocampal volume, BDNF, VEGF, or IGF-1 did not differ between the two groups. Post-hoc we found a positive association between change in hippocampal volume and verbal memory (Rho=0.27; p=0.05) and change in hippocampal volume and depressive symptoms (Rho=0.30; p=0.03). LIMITATIONS: Participation was low in both groups corresponding to an average participation of one session per week. CONCLUSION: Despite a significant increase in maximal oxygen uptake, a pragmatic exercise intervention did not increase hippocampal volume or resting levels of neurotrophines in out-patients with mild to moderate major depression. Trial identifier: ClinicalTrials.gov (NCT00695552). SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/24882173/The_effect_of_exercise_on_hippocampal_volume_and_neurotrophines_in_patients_with_major_depression__a_randomized_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(14)00235-3 DB - PRIME DP - Unbound Medicine ER -