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Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.
Biol Pharm Bull. 2014; 37(6):892-7.BP

Abstract

Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury.

Authors+Show Affiliations

Kuboyama T
Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama.
Tohda C
No affiliation info available
Komatsu K
No affiliation info available

MeSH

Alzheimer DiseaseHumansMedicine, AyurvedicMolecular StructureNeurodegenerative DiseasesNeuroprotective AgentsPlant ExtractsPlant RootsSpinal Cord InjuriesWithania

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24882401

Clinical Trial Links

Ashwagandha for Cognitive Dysfunction

Citation

Kuboyama, Tomoharu, et al. "Effects of Ashwagandha (roots of Withania Somnifera) On Neurodegenerative Diseases." Biological & Pharmaceutical Bulletin, vol. 37, no. 6, 2014, pp. 892-7.
Kuboyama T, Tohda C, Komatsu K. Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases. Biol Pharm Bull. 2014;37(6):892-7.
Kuboyama, T., Tohda, C., & Komatsu, K. (2014). Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases. Biological & Pharmaceutical Bulletin, 37(6), 892-7.
Kuboyama T, Tohda C, Komatsu K. Effects of Ashwagandha (roots of Withania Somnifera) On Neurodegenerative Diseases. Biol Pharm Bull. 2014;37(6):892-7. PubMed PMID: 24882401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases. AU - Kuboyama,Tomoharu, AU - Tohda,Chihiro, AU - Komatsu,Katsuko, PY - 2014/6/3/entrez PY - 2014/6/3/pubmed PY - 2015/1/21/medline SP - 892 EP - 7 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 37 IS - 6 N2 - Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury. SN - 1347-5215 UR - https://www.unboundmedicine.com/medline/citation/24882401/Effects_of_Ashwagandha__roots_of_Withania_somnifera__on_neurodegenerative_diseases_ DB - PRIME DP - Unbound Medicine ER -