Tags

Type your tag names separated by a space and hit enter

Neural reactivity to rewards and losses in offspring of mothers and fathers with histories of depressive and anxiety disorders.
J Abnorm Psychol. 2014 May; 123(2):287-297.JA

Abstract

Depression appears to be characterized by reduced neural reactivity to receipt of reward. Despite evidence of shared etiologies and high rates of comorbidity between depression and anxiety, this abnormality may be relatively specific to depression. However, it is unclear whether children at risk for depression also exhibit abnormal reward responding, and if so, whether risk for anxiety moderates this association. The feedback negativity (FN) is an event-related potential component sensitive to receipt of rewards versus losses that is reduced in depression. Using a large community sample (N = 407) of 9-year-old children who had never experienced a depressive episode, we examined whether histories of depression and anxiety in their parents were associated with the FN following monetary rewards and losses. Results indicated that maternal history of depression was associated with a blunted FN in offspring, but only when there was no maternal history of anxiety. In addition, greater severity of maternal depression was associated with greater blunting of the FN in children. No effects of paternal psychopathology were observed. Results suggest that blunted reactivity to rewards versus losses may be a vulnerability marker that is specific to pure depression, but is not evident when there is also familial risk for anxiety. In addition, these findings suggest that abnormal reward responding is evident as early as middle childhood, several years prior to the sharp increase in the prevalence of depression and rapid changes in neural reward circuitry in adolescence.

Authors+Show Affiliations

Department of Psychology, Stony Brook University.Department of Psychology, Stony Brook University.Department of Psychology, Stony Brook University.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24886003

Citation

Kujawa, Autumn, et al. "Neural Reactivity to Rewards and Losses in Offspring of Mothers and Fathers With Histories of Depressive and Anxiety Disorders." Journal of Abnormal Psychology, vol. 123, no. 2, 2014, pp. 287-297.
Kujawa A, Proudfit GH, Klein DN. Neural reactivity to rewards and losses in offspring of mothers and fathers with histories of depressive and anxiety disorders. J Abnorm Psychol. 2014;123(2):287-297.
Kujawa, A., Proudfit, G. H., & Klein, D. N. (2014). Neural reactivity to rewards and losses in offspring of mothers and fathers with histories of depressive and anxiety disorders. Journal of Abnormal Psychology, 123(2), 287-297. https://doi.org/10.1037/a0036285
Kujawa A, Proudfit GH, Klein DN. Neural Reactivity to Rewards and Losses in Offspring of Mothers and Fathers With Histories of Depressive and Anxiety Disorders. J Abnorm Psychol. 2014;123(2):287-297. PubMed PMID: 24886003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural reactivity to rewards and losses in offspring of mothers and fathers with histories of depressive and anxiety disorders. AU - Kujawa,Autumn, AU - Proudfit,Greg Hajcak, AU - Klein,Daniel N, PY - 2014/6/3/entrez PY - 2014/6/3/pubmed PY - 2015/9/4/medline SP - 287 EP - 297 JF - Journal of abnormal psychology JO - J Abnorm Psychol VL - 123 IS - 2 N2 - Depression appears to be characterized by reduced neural reactivity to receipt of reward. Despite evidence of shared etiologies and high rates of comorbidity between depression and anxiety, this abnormality may be relatively specific to depression. However, it is unclear whether children at risk for depression also exhibit abnormal reward responding, and if so, whether risk for anxiety moderates this association. The feedback negativity (FN) is an event-related potential component sensitive to receipt of rewards versus losses that is reduced in depression. Using a large community sample (N = 407) of 9-year-old children who had never experienced a depressive episode, we examined whether histories of depression and anxiety in their parents were associated with the FN following monetary rewards and losses. Results indicated that maternal history of depression was associated with a blunted FN in offspring, but only when there was no maternal history of anxiety. In addition, greater severity of maternal depression was associated with greater blunting of the FN in children. No effects of paternal psychopathology were observed. Results suggest that blunted reactivity to rewards versus losses may be a vulnerability marker that is specific to pure depression, but is not evident when there is also familial risk for anxiety. In addition, these findings suggest that abnormal reward responding is evident as early as middle childhood, several years prior to the sharp increase in the prevalence of depression and rapid changes in neural reward circuitry in adolescence. SN - 1939-1846 UR - https://www.unboundmedicine.com/medline/citation/24886003/Neural_reactivity_to_rewards_and_losses_in_offspring_of_mothers_and_fathers_with_histories_of_depressive_and_anxiety_disorders_ L2 - http://content.apa.org/journals/abn/123/2/287 DB - PRIME DP - Unbound Medicine ER -