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Prevalence and characterization of enterovirus infections among pediatric patients with hand foot mouth disease, herpangina and influenza like illness in Thailand, 2012.
PLoS One. 2014; 9(6):e98888.Plos

Abstract

Hand, foot, and mouth disease (HFMD) and herpangina are common infectious diseases caused by several genotypes of human enterovirus species A and frequently occurring in young children. This study was aimed at analyzing enteroviruses from patients with these diseases in Thailand in 2012. Detection and genotype determination of enteroviruses were accomplished by reverse transcription-polymerase chain reaction and sequencing of the VP1 region. Enterovirus-positive samples were differentiated into 17 genotypes (coxsackievirus A4 (CAV4), A5, A6, A8, A9, A10, A12, A16, A21, B1, B2, B4, B5, echovirus 7, 16, 25 and Enterovirus 71). The result showed CAV6 (33.5%), followed by CAV16 (9.4%) and EV71 (8.8%) as the most frequent genotypes in HFMD, CAV8 (19.3%) in herpangina and CAV6 (1.5%) in influenza like illness. Enterovirus infections were most prevalent during July with 34.4% in HFMD, 39.8% in herpangina and 1.6% in ILI. The higher enterovirus infection associated with HFMD and herpangina occurred in infants over one year-old. This represents the first report describing the circulation of multiple enteroviruses in Thailand.

Links

Publisher Full Text

ncbi.nlm.nih.gov

Authors+Show Affiliations

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Mauleekoonphairoj J

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Theamboonlers A

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

MeSH

AdolescentChildChild, PreschoolEnterovirusEnterovirus InfectionsFemaleGenotypeHand, Foot and Mouth DiseaseHerpanginaHumansInfantInfant, NewbornInfluenza, HumanMalePrevalenceThailand

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24887237

Citation

Puenpa, Jiratchaya, et al. "Prevalence and Characterization of Enterovirus Infections Among Pediatric Patients With Hand Foot Mouth Disease, Herpangina and Influenza Like Illness in Thailand, 2012." PloS One, vol. 9, no. 6, 2014, pp. e98888.

Puenpa J, Mauleekoonphairoj J, Linsuwanon P, et al. Prevalence and characterization of enterovirus infections among pediatric patients with hand foot mouth disease, herpangina and influenza like illness in Thailand, 2012. PLoS One. 2014;9(6):e98888.

Puenpa, J., Mauleekoonphairoj, J., Linsuwanon, P., Suwannakarn, K., Chieochansin, T., Korkong, S., Theamboonlers, A., & Poovorawan, Y. (2014). Prevalence and characterization of enterovirus infections among pediatric patients with hand foot mouth disease, herpangina and influenza like illness in Thailand, 2012. PloS One, 9(6), e98888. https://doi.org/10.1371/journal.pone.0098888

Puenpa J, et al. Prevalence and Characterization of Enterovirus Infections Among Pediatric Patients With Hand Foot Mouth Disease, Herpangina and Influenza Like Illness in Thailand, 2012. PLoS One. 2014;9(6):e98888. PubMed PMID: 24887237.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Prevalence and characterization of enterovirus infections among pediatric patients with hand foot mouth disease, herpangina and influenza like illness in Thailand, 2012. AU - Puenpa,Jiratchaya, AU - Mauleekoonphairoj,John, AU - Linsuwanon,Piyada, AU - Suwannakarn,Kamol, AU - Chieochansin,Thaweesak, AU - Korkong,Sumeth, AU - Theamboonlers,Apiradee, AU - Poovorawan,Yong, Y1 - 2014/06/02/ PY - 2013/12/12/received PY - 2014/05/07/accepted PY - 2014/6/3/entrez PY - 2014/6/3/pubmed PY - 2015/10/16/medline SP - e98888 EP - e98888 JF - PloS one JO - PLoS One VL - 9 IS - 6 N2 - Hand, foot, and mouth disease (HFMD) and herpangina are common infectious diseases caused by several genotypes of human enterovirus species A and frequently occurring in young children. This study was aimed at analyzing enteroviruses from patients with these diseases in Thailand in 2012. Detection and genotype determination of enteroviruses were accomplished by reverse transcription-polymerase chain reaction and sequencing of the VP1 region. Enterovirus-positive samples were differentiated into 17 genotypes (coxsackievirus A4 (CAV4), A5, A6, A8, A9, A10, A12, A16, A21, B1, B2, B4, B5, echovirus 7, 16, 25 and Enterovirus 71). The result showed CAV6 (33.5%), followed by CAV16 (9.4%) and EV71 (8.8%) as the most frequent genotypes in HFMD, CAV8 (19.3%) in herpangina and CAV6 (1.5%) in influenza like illness. Enterovirus infections were most prevalent during July with 34.4% in HFMD, 39.8% in herpangina and 1.6% in ILI. The higher enterovirus infection associated with HFMD and herpangina occurred in infants over one year-old. This represents the first report describing the circulation of multiple enteroviruses in Thailand. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24887237/Prevalence_and_characterization_of_enterovirus_infections_among_pediatric_patients_with_hand_foot_mouth_disease_herpangina_and_influenza_like_illness_in_Thailand_2012_ L2 - https://dx.plos.org/10.1371/journal.pone.0098888 DB - PRIME DP - Unbound Medicine ER -