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Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient.

Abstract

The most common malignant neurogenic tumors in children are neuroblastic tumors, classified as ganglioneuroblastoma or neuroblastoma. Ganglioneuroblastomas usually occur at the sympathetic ganglia in the mediastinum, whereas neuroblastomas occur in the abdominal cavity. We describe a case of large posterior mediastinal ganglioneuroblastoma extending from the aortic arch to the left renal hilum in a 17-year-old boy. Despite chemotherapy, post-treatment computed tomography showed disease progression. The patient underwent a thoracolaparotomy incision and excision of the tumor. These malignant mediastinal tumors can potentially grow to a very large size. If alternative treatment has failed, resection can be accomplished with relative safety.

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  • Authors+Show Affiliations

    ,

    Department of Cardiothoracic Surgery, Wessex Cardiac Centre, Southampton University Hospitals NHS Trust, Southampton, UK dimoskaragel@yahoo.gr.

    ,

    Department of Cardiothoracic Surgery, Wessex Cardiac Centre, Southampton University Hospitals NHS Trust, Southampton, UK.

    ,

    Department of Cardiothoracic Surgery, Wessex Cardiac Centre, Southampton University Hospitals NHS Trust, Southampton, UK.

    Department of Cardiothoracic Surgery, Wessex Cardiac Centre, Southampton University Hospitals NHS Trust, Southampton, UK.

    Source

    MeSH

    Adolescent
    Antineoplastic Combined Chemotherapy Protocols
    Aorta, Thoracic
    Carboplatin
    Disease Progression
    Etoposide
    Fatal Outcome
    Ganglioneuroblastoma
    Humans
    Kidney
    Laparotomy
    Male
    Mediastinal Neoplasms
    Neoplasm, Residual
    Thoracotomy
    Time Factors
    Tomography, X-Ray Computed
    Treatment Outcome
    Tumor Burden

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    24887835

    Citation

    Karangelis, Dimos, et al. "Giant Thoracoabdominal Ganglioneuroblastoma in a 17-year-old Patient." Asian Cardiovascular & Thoracic Annals, vol. 22, no. 6, 2014, pp. 739-41.
    Karangelis D, Nikolaidis N, Roubelakis A, et al. Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. Asian Cardiovasc Thorac Ann. 2014;22(6):739-41.
    Karangelis, D., Nikolaidis, N., Roubelakis, A., & Weeden, D. F. (2014). Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. Asian Cardiovascular & Thoracic Annals, 22(6), pp. 739-41. doi:10.1177/0218492313490410.
    Karangelis D, et al. Giant Thoracoabdominal Ganglioneuroblastoma in a 17-year-old Patient. Asian Cardiovasc Thorac Ann. 2014;22(6):739-41. PubMed PMID: 24887835.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. AU - Karangelis,Dimos, AU - Nikolaidis,Nicolas, AU - Roubelakis,Apostolos, AU - Weeden,David F, Y1 - 2013/08/16/ PY - 2014/6/3/entrez PY - 2014/6/3/pubmed PY - 2017/2/14/medline KW - Adolescent KW - ganglioneuroblastoma KW - peripheral nervous system neoplasms KW - thoracic surgery SP - 739 EP - 41 JF - Asian cardiovascular & thoracic annals JO - Asian Cardiovasc Thorac Ann VL - 22 IS - 6 N2 - The most common malignant neurogenic tumors in children are neuroblastic tumors, classified as ganglioneuroblastoma or neuroblastoma. Ganglioneuroblastomas usually occur at the sympathetic ganglia in the mediastinum, whereas neuroblastomas occur in the abdominal cavity. We describe a case of large posterior mediastinal ganglioneuroblastoma extending from the aortic arch to the left renal hilum in a 17-year-old boy. Despite chemotherapy, post-treatment computed tomography showed disease progression. The patient underwent a thoracolaparotomy incision and excision of the tumor. These malignant mediastinal tumors can potentially grow to a very large size. If alternative treatment has failed, resection can be accomplished with relative safety. SN - 1816-5370 UR - https://www.unboundmedicine.com/medline/citation/24887835/Giant_thoracoabdominal_ganglioneuroblastoma_in_a_17_year_old_patient_ L2 - http://journals.sagepub.com/doi/full/10.1177/0218492313490410?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -