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Elevated perioperative serum CA 19-9 levels are independent predictors of poor survival in patients with resectable cholangiocarcinoma.
J Surg Oncol. 2014 Sep; 110(4):422-9.JS

Abstract

BACKGROUND AND OBJECTIVES

Identification of prognostic markers is important to establish a perioperative therapeutic strategy for resectable cholangiocarcinoma (CC). The aim of this study was to investigate whether perioperative serum carbohydrate antigen 19-9 (CA19-9) levels can predict survival of patients who underwent surgical resection for CC.

METHODS

The study included 106 patients who underwent surgical resection for CC. Serum CA19-9 levels were measured preoperatively after biliary drainage and postoperatively about 4 weeks after surgery. The association of clinicopathological factors (including perioperative serum CA19-9 levels) with overall survival (OS) was analyzed with univariate and multivariate analyses.

RESULTS

Differences in OS were significant between groups divided on the basis of two preoperative CA19-9 cutoff values (in U/ml) of 37 and 200 and three postoperative CA19-9 cutoff values (in U/ml) of 37, 100, and 200. In multivariate analysis, absence of postoperative adjuvant chemotherapy (P = 0.002), lymph node metastasis (P = 0.0002), preoperative CA19-9 (≥ 200 IU/ml) (P = 0.03), and postoperative CA19-9 (≥ 37 IU/ml) (P < 0.0001) were identified as independent predictors of poor OS.

CONCLUSION

Both pre- and postoperative serum CA19-9 levels predict the survival of patients with resectable CC, and may contribute to the establishment of a new therapeutic strategy.

Authors+Show Affiliations

Department of Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24889968

Citation

Kondo, Naru, et al. "Elevated Perioperative Serum CA 19-9 Levels Are Independent Predictors of Poor Survival in Patients With Resectable Cholangiocarcinoma." Journal of Surgical Oncology, vol. 110, no. 4, 2014, pp. 422-9.
Kondo N, Murakami Y, Uemura K, et al. Elevated perioperative serum CA 19-9 levels are independent predictors of poor survival in patients with resectable cholangiocarcinoma. J Surg Oncol. 2014;110(4):422-9.
Kondo, N., Murakami, Y., Uemura, K., Sudo, T., Hashimoto, Y., Sasaki, H., & Sueda, T. (2014). Elevated perioperative serum CA 19-9 levels are independent predictors of poor survival in patients with resectable cholangiocarcinoma. Journal of Surgical Oncology, 110(4), 422-9. https://doi.org/10.1002/jso.23666
Kondo N, et al. Elevated Perioperative Serum CA 19-9 Levels Are Independent Predictors of Poor Survival in Patients With Resectable Cholangiocarcinoma. J Surg Oncol. 2014;110(4):422-9. PubMed PMID: 24889968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated perioperative serum CA 19-9 levels are independent predictors of poor survival in patients with resectable cholangiocarcinoma. AU - Kondo,Naru, AU - Murakami,Yoshiaki, AU - Uemura,Kenichiro, AU - Sudo,Takeshi, AU - Hashimoto,Yasushi, AU - Sasaki,Hayato, AU - Sueda,Taijiro, Y1 - 2014/06/02/ PY - 2014/02/20/received PY - 2014/05/02/accepted PY - 2014/6/4/entrez PY - 2014/6/4/pubmed PY - 2014/10/1/medline KW - CA19-9 KW - cholangiocarcinoma KW - predictive marker KW - surgical resection SP - 422 EP - 9 JF - Journal of surgical oncology JO - J Surg Oncol VL - 110 IS - 4 N2 - BACKGROUND AND OBJECTIVES: Identification of prognostic markers is important to establish a perioperative therapeutic strategy for resectable cholangiocarcinoma (CC). The aim of this study was to investigate whether perioperative serum carbohydrate antigen 19-9 (CA19-9) levels can predict survival of patients who underwent surgical resection for CC. METHODS: The study included 106 patients who underwent surgical resection for CC. Serum CA19-9 levels were measured preoperatively after biliary drainage and postoperatively about 4 weeks after surgery. The association of clinicopathological factors (including perioperative serum CA19-9 levels) with overall survival (OS) was analyzed with univariate and multivariate analyses. RESULTS: Differences in OS were significant between groups divided on the basis of two preoperative CA19-9 cutoff values (in U/ml) of 37 and 200 and three postoperative CA19-9 cutoff values (in U/ml) of 37, 100, and 200. In multivariate analysis, absence of postoperative adjuvant chemotherapy (P = 0.002), lymph node metastasis (P = 0.0002), preoperative CA19-9 (≥ 200 IU/ml) (P = 0.03), and postoperative CA19-9 (≥ 37 IU/ml) (P < 0.0001) were identified as independent predictors of poor OS. CONCLUSION: Both pre- and postoperative serum CA19-9 levels predict the survival of patients with resectable CC, and may contribute to the establishment of a new therapeutic strategy. SN - 1096-9098 UR - https://www.unboundmedicine.com/medline/citation/24889968/Elevated_perioperative_serum_CA_19_9_levels_are_independent_predictors_of_poor_survival_in_patients_with_resectable_cholangiocarcinoma_ L2 - https://doi.org/10.1002/jso.23666 DB - PRIME DP - Unbound Medicine ER -