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Functional relationship between oxytocin and appetite for carbohydrates versus saccharin.
Neuroreport. 2014 Aug 20; 25(12):909-14.N

Abstract

Centrally acting oxytocin (OT) inhibits feeding. Recent evidence suggests a link between OT and control of carbohydrate and saccharin intake, but it is unclear whether OT affects appetite for only carbohydrates, especially sweet ones, or sweet tastants irrespective of their carbohydrate content. Therefore, a blood-brain barrier penetrant OT receptor antagonist, L-368,899, was administered in mice and intake of liquid diets containing carbohydrates sucrose, glucose, fructose, polycose, or cornstarch (CS) or the noncarbohydrate, noncaloric sweetener saccharin was studied in episodic intake paradigms: one in which only one tastant was available and the other in which a choice between a carbohydrate (sucrose, glucose, or fructose) and saccharin was provided. We also used real-time PCR to examine hypothalamic Ot mRNA levels in mice provided short-term access to sucrose, CS, or saccharin. In the no-choice paradigm, L-368,899 increased the intake of all carbohydrates, whereas its effect on saccharin consumption showed only a trend. A 10 times lower dose (0.3 mg/kg) stimulated intake of sucrose than other carbohydrates. In the choice test, a very low 0.1 mg/kg dose of L-368,899 doubled the proportion of sucrose consumption relative to saccharin, but did not affect fructose or glucose preference. Ot gene expression increased after sucrose and CS, but not saccharin exposure compared with the controls; however, a higher level of significance was detected in the sucrose group. We conclude that OT inhibits appetite for carbohydrates. Sucrose consumption considerably enhances Ot gene expression and is particularly sensitive to OT receptor blockade, suggesting a special functional relationship between OT and sugar intake.

Authors+Show Affiliations

aDepartment of Biological Sciences, University of Waikato, Hamilton, New Zealand bDepartment of Food Science and Nutrition, University of Minnesota cMinnesota Obesity Center, St Paul, Minnesota, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24893201

Citation

Herisson, Florence M., et al. "Functional Relationship Between Oxytocin and Appetite for Carbohydrates Versus Saccharin." Neuroreport, vol. 25, no. 12, 2014, pp. 909-14.
Herisson FM, Brooks LL, Waas JR, et al. Functional relationship between oxytocin and appetite for carbohydrates versus saccharin. Neuroreport. 2014;25(12):909-14.
Herisson, F. M., Brooks, L. L., Waas, J. R., Levine, A. S., & Olszewski, P. K. (2014). Functional relationship between oxytocin and appetite for carbohydrates versus saccharin. Neuroreport, 25(12), 909-14. https://doi.org/10.1097/WNR.0000000000000201
Herisson FM, et al. Functional Relationship Between Oxytocin and Appetite for Carbohydrates Versus Saccharin. Neuroreport. 2014 Aug 20;25(12):909-14. PubMed PMID: 24893201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional relationship between oxytocin and appetite for carbohydrates versus saccharin. AU - Herisson,Florence M, AU - Brooks,Lydia L, AU - Waas,Joseph R, AU - Levine,Allen S, AU - Olszewski,Pawel K, PY - 2014/6/4/entrez PY - 2014/6/4/pubmed PY - 2015/2/25/medline SP - 909 EP - 14 JF - Neuroreport JO - Neuroreport VL - 25 IS - 12 N2 - Centrally acting oxytocin (OT) inhibits feeding. Recent evidence suggests a link between OT and control of carbohydrate and saccharin intake, but it is unclear whether OT affects appetite for only carbohydrates, especially sweet ones, or sweet tastants irrespective of their carbohydrate content. Therefore, a blood-brain barrier penetrant OT receptor antagonist, L-368,899, was administered in mice and intake of liquid diets containing carbohydrates sucrose, glucose, fructose, polycose, or cornstarch (CS) or the noncarbohydrate, noncaloric sweetener saccharin was studied in episodic intake paradigms: one in which only one tastant was available and the other in which a choice between a carbohydrate (sucrose, glucose, or fructose) and saccharin was provided. We also used real-time PCR to examine hypothalamic Ot mRNA levels in mice provided short-term access to sucrose, CS, or saccharin. In the no-choice paradigm, L-368,899 increased the intake of all carbohydrates, whereas its effect on saccharin consumption showed only a trend. A 10 times lower dose (0.3 mg/kg) stimulated intake of sucrose than other carbohydrates. In the choice test, a very low 0.1 mg/kg dose of L-368,899 doubled the proportion of sucrose consumption relative to saccharin, but did not affect fructose or glucose preference. Ot gene expression increased after sucrose and CS, but not saccharin exposure compared with the controls; however, a higher level of significance was detected in the sucrose group. We conclude that OT inhibits appetite for carbohydrates. Sucrose consumption considerably enhances Ot gene expression and is particularly sensitive to OT receptor blockade, suggesting a special functional relationship between OT and sugar intake. SN - 1473-558X UR - https://www.unboundmedicine.com/medline/citation/24893201/Functional_relationship_between_oxytocin_and_appetite_for_carbohydrates_versus_saccharin_ L2 - https://doi.org/10.1097/WNR.0000000000000201 DB - PRIME DP - Unbound Medicine ER -