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Dietary fat intake in relation to lethal breast cancer in two large prospective cohort studies.
Breast Cancer Res Treat 2014; 146(2):383-92BC

Abstract

Whether fat intake influences risk of developing more aggressive, lethal breast tumors is unknown. We evaluated intakes of total fat, specific types of fat, and cholesterol prior to diagnosis in relation to lethal breast cancer risk in 88,759 women in the Nurses' Health Study (NHS; 1980-2010) and 93,912 women in the Nurses' Health Study II (NHSII; 1991-2010). Diet was assessed every 4 years using a semi-quantitative food frequency questionnaire. Breast cancers were confirmed with pathology reports; deaths were confirmed by next of kin or the National Death Index. We defined lethal cases as women with invasive breast cancer who died of breast cancer. We pooled the cohorts and used multivariable Cox proportional hazards models. We identified 1,529 lethal breast cancer cases (1,279 in NHS and 250 in NHSII). Higher total fat intake was associated with a slightly lower lethal breast cancer risk (top vs. bottom quintile hazard ratio [HR] 0.85; 95 % CI 0.72, 1.01; p trend = 0.05). Specific types of fat were generally not associated with lethal breast cancer risk. For example, compared with those in the lowest quintile of saturated fat intake, those in the highest quintile had a HR of 0.98 (95 % CI 0.75, 1.26; p trend = 0.96). Among women diagnosed with breast cancer, pre-diagnosis fat intake was not associated with survival. Higher pre-diagnosis fat intake was not associated with greater risk of lethal breast cancer in these large prospective cohort studies, consistent with the weight of the evidence against a causal role for fat intake and breast cancer incidence.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA, caroline.boeke@mail.harvard.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24894342

Citation

Boeke, Caroline E., et al. "Dietary Fat Intake in Relation to Lethal Breast Cancer in Two Large Prospective Cohort Studies." Breast Cancer Research and Treatment, vol. 146, no. 2, 2014, pp. 383-92.
Boeke CE, Eliassen AH, Chen WY, et al. Dietary fat intake in relation to lethal breast cancer in two large prospective cohort studies. Breast Cancer Res Treat. 2014;146(2):383-92.
Boeke, C. E., Eliassen, A. H., Chen, W. Y., Cho, E., Holmes, M. D., Rosner, B., ... Tamimi, R. M. (2014). Dietary fat intake in relation to lethal breast cancer in two large prospective cohort studies. Breast Cancer Research and Treatment, 146(2), pp. 383-92. doi:10.1007/s10549-014-3005-8.
Boeke CE, et al. Dietary Fat Intake in Relation to Lethal Breast Cancer in Two Large Prospective Cohort Studies. Breast Cancer Res Treat. 2014;146(2):383-92. PubMed PMID: 24894342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat intake in relation to lethal breast cancer in two large prospective cohort studies. AU - Boeke,Caroline E, AU - Eliassen,A Heather, AU - Chen,Wendy Y, AU - Cho,Eunyoung, AU - Holmes,Michelle D, AU - Rosner,Bernard, AU - Willett,Walter C, AU - Tamimi,Rulla M, Y1 - 2014/06/04/ PY - 2014/05/19/received PY - 2014/05/20/accepted PY - 2014/6/5/entrez PY - 2014/6/5/pubmed PY - 2015/8/19/medline SP - 383 EP - 92 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 146 IS - 2 N2 - Whether fat intake influences risk of developing more aggressive, lethal breast tumors is unknown. We evaluated intakes of total fat, specific types of fat, and cholesterol prior to diagnosis in relation to lethal breast cancer risk in 88,759 women in the Nurses' Health Study (NHS; 1980-2010) and 93,912 women in the Nurses' Health Study II (NHSII; 1991-2010). Diet was assessed every 4 years using a semi-quantitative food frequency questionnaire. Breast cancers were confirmed with pathology reports; deaths were confirmed by next of kin or the National Death Index. We defined lethal cases as women with invasive breast cancer who died of breast cancer. We pooled the cohorts and used multivariable Cox proportional hazards models. We identified 1,529 lethal breast cancer cases (1,279 in NHS and 250 in NHSII). Higher total fat intake was associated with a slightly lower lethal breast cancer risk (top vs. bottom quintile hazard ratio [HR] 0.85; 95 % CI 0.72, 1.01; p trend = 0.05). Specific types of fat were generally not associated with lethal breast cancer risk. For example, compared with those in the lowest quintile of saturated fat intake, those in the highest quintile had a HR of 0.98 (95 % CI 0.75, 1.26; p trend = 0.96). Among women diagnosed with breast cancer, pre-diagnosis fat intake was not associated with survival. Higher pre-diagnosis fat intake was not associated with greater risk of lethal breast cancer in these large prospective cohort studies, consistent with the weight of the evidence against a causal role for fat intake and breast cancer incidence. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/24894342/Dietary_fat_intake_in_relation_to_lethal_breast_cancer_in_two_large_prospective_cohort_studies_ L2 - https://doi.org/10.1007/s10549-014-3005-8 DB - PRIME DP - Unbound Medicine ER -