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Just say 'know': how do cannabinoid concentrations influence users' estimates of cannabis potency and the amount they roll in joints?
Addiction 2014; 109(10):1686-94A

Abstract

AIMS

(1) To determine whether measured concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in individuals' own cannabis predict their estimates of drug potency and actual titration; and (2) to ascertain if these effects are influenced by frequency of use and cannabis type.

DESIGN

Cross-sectional, naturalistic.

SETTING

Participants' own homes.

PARTICIPANTS

A total of 247 cannabis users in the United Kingdom: 152 'recreational' (1-24 days/month) and 95 'daily' (≥25 days/month).

METHODS

Participants rated their own cannabis for its potency (1-10) and type ('resin', 'herbal', 'skunk') before smoking it in front of the researcher. The amount of cannabis (g) used in their joints was recorded and an additional sample was analysed for THC and CBD concentrations (%).

FINDINGS

THC concentrations were related negatively to the amount of cannabis used [unstandardized regression coefficient: b = -0.009, 95% confidence interval (CI) = -0.017, -0.002]. Potency estimates were predicted by increasing THC (b = 0.055, 95% CI = 0.020, 0.090) and decreasing CBD (b = -0.160, 95% CI = -0.284, -0.062), and both of these associations were mediated by cannabis type (THC: b = 0.018, 95% CI = 0.006, 0.037; CBD: b = -0.105, 95% CI = -0.198, -0.028). Potency estimates were more reflective of THC as frequency of use increased (b = 0.004, 95% CI = 0.001, 0.007) and were 7.3 times more so in daily (partial r = 0.381) than recreational users (r = 0.052).

CONCLUSIONS

When using their own cannabis in a naturalistic setting, people titrate the amount they roll in joints according to concentrations of delta-9-tetrahydrocannabinol (THC) but not cannabidiol (CBD). Recreational users thus show poor understanding of cannabis potency.

Authors+Show Affiliations

Clinical Psychopharmacology Unit, University College London, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24894801

Citation

Freeman, Tom P., et al. "Just Say 'know': How Do Cannabinoid Concentrations Influence Users' Estimates of Cannabis Potency and the Amount They Roll in Joints?" Addiction (Abingdon, England), vol. 109, no. 10, 2014, pp. 1686-94.
Freeman TP, Morgan CJ, Hindocha C, et al. Just say 'know': how do cannabinoid concentrations influence users' estimates of cannabis potency and the amount they roll in joints? Addiction. 2014;109(10):1686-94.
Freeman, T. P., Morgan, C. J., Hindocha, C., Schafer, G., Das, R. K., & Curran, H. V. (2014). Just say 'know': how do cannabinoid concentrations influence users' estimates of cannabis potency and the amount they roll in joints? Addiction (Abingdon, England), 109(10), pp. 1686-94. doi:10.1111/add.12634.
Freeman TP, et al. Just Say 'know': How Do Cannabinoid Concentrations Influence Users' Estimates of Cannabis Potency and the Amount They Roll in Joints. Addiction. 2014;109(10):1686-94. PubMed PMID: 24894801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Just say 'know': how do cannabinoid concentrations influence users' estimates of cannabis potency and the amount they roll in joints? AU - Freeman,Tom P, AU - Morgan,Celia J A, AU - Hindocha,Chandni, AU - Schafer,Gráinne, AU - Das,Ravi K, AU - Curran,H Valerie, Y1 - 2014/07/16/ PY - 2014/02/07/received PY - 2014/04/09/revised PY - 2014/05/29/accepted PY - 2014/6/5/entrez PY - 2014/6/5/pubmed PY - 2015/10/21/medline KW - CBD KW - Cannabis KW - THC KW - daily KW - harm reduction KW - marijuana KW - potency KW - quantity KW - recreational KW - titration SP - 1686 EP - 94 JF - Addiction (Abingdon, England) JO - Addiction VL - 109 IS - 10 N2 - AIMS: (1) To determine whether measured concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in individuals' own cannabis predict their estimates of drug potency and actual titration; and (2) to ascertain if these effects are influenced by frequency of use and cannabis type. DESIGN: Cross-sectional, naturalistic. SETTING: Participants' own homes. PARTICIPANTS: A total of 247 cannabis users in the United Kingdom: 152 'recreational' (1-24 days/month) and 95 'daily' (≥25 days/month). METHODS: Participants rated their own cannabis for its potency (1-10) and type ('resin', 'herbal', 'skunk') before smoking it in front of the researcher. The amount of cannabis (g) used in their joints was recorded and an additional sample was analysed for THC and CBD concentrations (%). FINDINGS: THC concentrations were related negatively to the amount of cannabis used [unstandardized regression coefficient: b = -0.009, 95% confidence interval (CI) = -0.017, -0.002]. Potency estimates were predicted by increasing THC (b = 0.055, 95% CI = 0.020, 0.090) and decreasing CBD (b = -0.160, 95% CI = -0.284, -0.062), and both of these associations were mediated by cannabis type (THC: b = 0.018, 95% CI = 0.006, 0.037; CBD: b = -0.105, 95% CI = -0.198, -0.028). Potency estimates were more reflective of THC as frequency of use increased (b = 0.004, 95% CI = 0.001, 0.007) and were 7.3 times more so in daily (partial r = 0.381) than recreational users (r = 0.052). CONCLUSIONS: When using their own cannabis in a naturalistic setting, people titrate the amount they roll in joints according to concentrations of delta-9-tetrahydrocannabinol (THC) but not cannabidiol (CBD). Recreational users thus show poor understanding of cannabis potency. SN - 1360-0443 UR - https://www.unboundmedicine.com/medline/citation/24894801/Just_say_'know':_how_do_cannabinoid_concentrations_influence_users'_estimates_of_cannabis_potency_and_the_amount_they_roll_in_joints L2 - https://doi.org/10.1111/add.12634 DB - PRIME DP - Unbound Medicine ER -