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TRP channels in lower urinary tract dysfunction.
Br J Pharmacol. 2014 May; 171(10):2537-51.BJ

Abstract

Lower urinary tract dysfunction (LUTd) represents a major healthcare problem. Although it is mostly not lethal, associated social disturbance, medical costs, loss of productivity and especially diminished quality of life should not be underestimated. Although more than 15% of people suffer from a form of LUTd to some extent, pathophysiology often remains obscure. In the past 20 years, transient receptor potential (TRP) channels have become increasingly important in this field of research. These intriguing ion channels are believed to be the main molecular sensors that generate bladder sensation. Therefore, they are intensely pursued as new drug targets for both curative and symptomatic treatment of different forms of LUTd. TRPV1 was the first of its class to be investigated. Actually, even before this channel was cloned, it had already been targeted in the bladder, with clinical trials of intravesical capsaicin instillations. Several other polymodally gated TRP channels, particularly TRPM8, TRPA1 and TRPV4, also appear to play a prominent role in bladder (patho)physiology. With this review, we provide a brief overview of current knowledge on the role of these TRP channels in LUTd and their potential as molecular targets for treatment.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24895732

Citation

Franken, J, et al. "TRP Channels in Lower Urinary Tract Dysfunction." British Journal of Pharmacology, vol. 171, no. 10, 2014, pp. 2537-51.
Franken J, Uvin P, De Ridder D, et al. TRP channels in lower urinary tract dysfunction. Br J Pharmacol. 2014;171(10):2537-51.
Franken, J., Uvin, P., De Ridder, D., & Voets, T. (2014). TRP channels in lower urinary tract dysfunction. British Journal of Pharmacology, 171(10), 2537-51.
Franken J, et al. TRP Channels in Lower Urinary Tract Dysfunction. Br J Pharmacol. 2014;171(10):2537-51. PubMed PMID: 24895732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRP channels in lower urinary tract dysfunction. AU - Franken,J, AU - Uvin,P, AU - De Ridder,D, AU - Voets,T, PY - 2014/6/5/entrez PY - 2014/6/5/pubmed PY - 2014/12/17/medline SP - 2537 EP - 51 JF - British journal of pharmacology JO - Br J Pharmacol VL - 171 IS - 10 N2 - Lower urinary tract dysfunction (LUTd) represents a major healthcare problem. Although it is mostly not lethal, associated social disturbance, medical costs, loss of productivity and especially diminished quality of life should not be underestimated. Although more than 15% of people suffer from a form of LUTd to some extent, pathophysiology often remains obscure. In the past 20 years, transient receptor potential (TRP) channels have become increasingly important in this field of research. These intriguing ion channels are believed to be the main molecular sensors that generate bladder sensation. Therefore, they are intensely pursued as new drug targets for both curative and symptomatic treatment of different forms of LUTd. TRPV1 was the first of its class to be investigated. Actually, even before this channel was cloned, it had already been targeted in the bladder, with clinical trials of intravesical capsaicin instillations. Several other polymodally gated TRP channels, particularly TRPM8, TRPA1 and TRPV4, also appear to play a prominent role in bladder (patho)physiology. With this review, we provide a brief overview of current knowledge on the role of these TRP channels in LUTd and their potential as molecular targets for treatment. SN - 1476-5381 UR - https://www.unboundmedicine.com/medline/citation/24895732/TRP_channels_in_lower_urinary_tract_dysfunction_ L2 - https://doi.org/10.1111/bph.12502 DB - PRIME DP - Unbound Medicine ER -