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Red yeast rice and coenzyme Q10 as safe alternatives to surmount atorvastatin-induced myopathy in hyperlipidemic rats.
Can J Physiol Pharmacol. 2014 Jun; 92(6):481-9.CJ

Abstract

Statins are the first line treatment for the management of hyperlipidemia. However, the primary adverse effect limiting their use is myopathy. This study examines the efficacy and safety of red yeast rice (RYR), a source of natural statins, as compared with atorvastatin, which is the most widely used synthetic statin. Statin interference with the endogenous synthesis of coenzyme Q10 (CoQ10) prompted the hypothesis that its deficiency may be implicated in the pathogenesis of statin-associated myopathy. Hence, the effects of combination of CoQ10 with either statin have been evaluated. Rats were rendered hyperlipidemic through feeding them a high-fat diet for 90 days, during the last 30 days of the diet they were treated daily with either atorvastatin, RYR, CoQ10, or combined regimens. Lipid profile, liver function tests, and creatine kinase were monitored after 15 and 30 days of drug treatments. Heart contents of CoQ9 and CoQ10 were assessed and histopathological examination of the liver and aortic wall was performed. RYR and CoQ10 had the advantage over atorvastatin in that they lower cholesterol without elevating creatine kinase, a hallmark of myopathy. RYR maintained normal levels of heart ubiquinones, which are essential components for energy production in muscles. In conclusion, RYR and CoQ10 may offer alternatives to overcome atorvastatin-associated myopathy.

Authors+Show Affiliations

a Department of Pharmacology, Medical Research Division, National Research Centre, El Tahrir Street, 12622 Giza, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24896301

Citation

Abdelbaset, Marwan, et al. "Red Yeast Rice and Coenzyme Q10 as Safe Alternatives to Surmount Atorvastatin-induced Myopathy in Hyperlipidemic Rats." Canadian Journal of Physiology and Pharmacology, vol. 92, no. 6, 2014, pp. 481-9.
Abdelbaset M, Safar MM, Mahmoud SS, et al. Red yeast rice and coenzyme Q10 as safe alternatives to surmount atorvastatin-induced myopathy in hyperlipidemic rats. Can J Physiol Pharmacol. 2014;92(6):481-9.
Abdelbaset, M., Safar, M. M., Mahmoud, S. S., Negm, S. A., & Agha, A. M. (2014). Red yeast rice and coenzyme Q10 as safe alternatives to surmount atorvastatin-induced myopathy in hyperlipidemic rats. Canadian Journal of Physiology and Pharmacology, 92(6), 481-9. https://doi.org/10.1139/cjpp-2013-0430
Abdelbaset M, et al. Red Yeast Rice and Coenzyme Q10 as Safe Alternatives to Surmount Atorvastatin-induced Myopathy in Hyperlipidemic Rats. Can J Physiol Pharmacol. 2014;92(6):481-9. PubMed PMID: 24896301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red yeast rice and coenzyme Q10 as safe alternatives to surmount atorvastatin-induced myopathy in hyperlipidemic rats. AU - Abdelbaset,Marwan, AU - Safar,Marwa M, AU - Mahmoud,Sawsan S, AU - Negm,Seham A, AU - Agha,Azza M, Y1 - 2014/04/28/ PY - 2014/6/5/entrez PY - 2014/6/5/pubmed PY - 2015/9/1/medline KW - atorvastatin KW - atorvastatine KW - coenzyme Q10 KW - hyperlipidemia KW - hyperlipémie KW - levure de riz rouge KW - myopathie KW - myopathy KW - red yeast rice KW - ubiquinones SP - 481 EP - 9 JF - Canadian journal of physiology and pharmacology JO - Can J Physiol Pharmacol VL - 92 IS - 6 N2 - Statins are the first line treatment for the management of hyperlipidemia. However, the primary adverse effect limiting their use is myopathy. This study examines the efficacy and safety of red yeast rice (RYR), a source of natural statins, as compared with atorvastatin, which is the most widely used synthetic statin. Statin interference with the endogenous synthesis of coenzyme Q10 (CoQ10) prompted the hypothesis that its deficiency may be implicated in the pathogenesis of statin-associated myopathy. Hence, the effects of combination of CoQ10 with either statin have been evaluated. Rats were rendered hyperlipidemic through feeding them a high-fat diet for 90 days, during the last 30 days of the diet they were treated daily with either atorvastatin, RYR, CoQ10, or combined regimens. Lipid profile, liver function tests, and creatine kinase were monitored after 15 and 30 days of drug treatments. Heart contents of CoQ9 and CoQ10 were assessed and histopathological examination of the liver and aortic wall was performed. RYR and CoQ10 had the advantage over atorvastatin in that they lower cholesterol without elevating creatine kinase, a hallmark of myopathy. RYR maintained normal levels of heart ubiquinones, which are essential components for energy production in muscles. In conclusion, RYR and CoQ10 may offer alternatives to overcome atorvastatin-associated myopathy. SN - 1205-7541 UR - https://www.unboundmedicine.com/medline/citation/24896301/Red_yeast_rice_and_coenzyme_Q10_as_safe_alternatives_to_surmount_atorvastatin_induced_myopathy_in_hyperlipidemic_rats_ L2 - https://cdnsciencepub.com/doi/10.1139/cjpp-2013-0430?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -