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Evidence for camel-to-human transmission of MERS coronavirus.
N Engl J Med. 2014 Jun 26; 370(26):2499-505.NEJM

Abstract

We describe the isolation and sequencing of Middle East respiratory syndrome coronavirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirmed MERS-CoV infection after close contact with camels that had rhinorrhea. Nasal swabs collected from the patient and from one of his nine camels were positive for MERS-CoV RNA. In addition, MERS-CoV was isolated from the patient and the camel. The full genome sequences of the two isolates were identical. Serologic data indicated that MERS-CoV was circulating in the camels but not in the patient before the human infection occurred. These data suggest that this fatal case of human MERS-CoV infection was transmitted through close contact with an infected camel.

Authors+Show Affiliations

From the Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences (E.I.A.), Special Infectious Agents Unit, King Fahd Medical Research Center (E.I.A., S.A.E., S.A.F., A.M. Hassan, M.S.A., A.M. Hashem), and the Departments of Medical Microbiology and Parasitology (A.M. Hashem) and Medicine (T.A.M.), Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24896817

Citation

Azhar, Esam I., et al. "Evidence for Camel-to-human Transmission of MERS Coronavirus." The New England Journal of Medicine, vol. 370, no. 26, 2014, pp. 2499-505.
Azhar EI, El-Kafrawy SA, Farraj SA, et al. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014;370(26):2499-505.
Azhar, E. I., El-Kafrawy, S. A., Farraj, S. A., Hassan, A. M., Al-Saeed, M. S., Hashem, A. M., & Madani, T. A. (2014). Evidence for camel-to-human transmission of MERS coronavirus. The New England Journal of Medicine, 370(26), 2499-505. https://doi.org/10.1056/NEJMoa1401505
Azhar EI, et al. Evidence for Camel-to-human Transmission of MERS Coronavirus. N Engl J Med. 2014 Jun 26;370(26):2499-505. PubMed PMID: 24896817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for camel-to-human transmission of MERS coronavirus. AU - Azhar,Esam I, AU - El-Kafrawy,Sherif A, AU - Farraj,Suha A, AU - Hassan,Ahmed M, AU - Al-Saeed,Muneera S, AU - Hashem,Anwar M, AU - Madani,Tariq A, Y1 - 2014/06/04/ PY - 2014/6/5/entrez PY - 2014/6/5/pubmed PY - 2014/7/1/medline SP - 2499 EP - 505 JF - The New England journal of medicine JO - N Engl J Med VL - 370 IS - 26 N2 - We describe the isolation and sequencing of Middle East respiratory syndrome coronavirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirmed MERS-CoV infection after close contact with camels that had rhinorrhea. Nasal swabs collected from the patient and from one of his nine camels were positive for MERS-CoV RNA. In addition, MERS-CoV was isolated from the patient and the camel. The full genome sequences of the two isolates were identical. Serologic data indicated that MERS-CoV was circulating in the camels but not in the patient before the human infection occurred. These data suggest that this fatal case of human MERS-CoV infection was transmitted through close contact with an infected camel. SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/24896817/Evidence_for_camel_to_human_transmission_of_MERS_coronavirus_ L2 - https://www.nejm.org/doi/10.1056/NEJMoa1401505?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -