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Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and risk of childhood brain tumors.
Nutr Cancer. 2014; 66(5):800-9.NC

Abstract

Childhood brain tumors (CBT) are the second most common childhood cancers, yet their etiology is largely unknown. We investigated whether maternal gestational intake of folate and vitamins B6 and B12 was associated with CBT risk in a nationwide case-control study conducted 2005-2010. Case children 0-14 years were recruited from all 10 Australian pediatric oncology centers. Control children were recruited by national random digit dialing, frequency matched to cases on age, sex, and state of residence. Dietary intake was ascertained using food frequency questionnaires and adjusted for total energy intake. Data from 293 case and 726 control mothers were analyzed using unconditional logistic regression. The odds ratio (OR) for the highest versus lowest tertile of folate intake was 0.70 [95% confidence interval (CI): 0.48, 1.02]. The ORs appeared lower in mothers who drank alcohol during pregnancy (OR = 0.45, 95% CI: 0.22, 0.93), mothers who took folic acid (OR = 0.67, 95% CI: 0.42, 1.06) or B6/B12 supplements (OR = 0.51, 95% CI: 0.25, 1.06) and in children younger than 5 years (OR = 0.50, 95% CI: 0.27, 0.93). These findings are consistent with folate's crucial role in maintenance of genomic integrity and DNA methylation. Dietary intake of B6 and B12 was not associated with risk of CBT.

Authors+Show Affiliations

a Telethon Kids Institute , University of Western Australia , Perth , Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24897174

Citation

Greenop, Kathryn R., et al. "Maternal Dietary Intake of Folate and Vitamins B6 and B12 During Pregnancy and Risk of Childhood Brain Tumors." Nutrition and Cancer, vol. 66, no. 5, 2014, pp. 800-9.
Greenop KR, Miller M, de Klerk NH, et al. Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and risk of childhood brain tumors. Nutr Cancer. 2014;66(5):800-9.
Greenop, K. R., Miller, M., de Klerk, N. H., Scott, R. J., Attia, J., Ashton, L. J., Dalla-Pozza, L., Bower, C., Armstrong, B. K., & Milne, E. (2014). Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and risk of childhood brain tumors. Nutrition and Cancer, 66(5), 800-9. https://doi.org/10.1080/01635581.2014.916326
Greenop KR, et al. Maternal Dietary Intake of Folate and Vitamins B6 and B12 During Pregnancy and Risk of Childhood Brain Tumors. Nutr Cancer. 2014;66(5):800-9. PubMed PMID: 24897174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and risk of childhood brain tumors. AU - Greenop,Kathryn R, AU - Miller,Margaret, AU - de Klerk,Nicholas H, AU - Scott,Rodney J, AU - Attia,John, AU - Ashton,Lesley J, AU - Dalla-Pozza,Luciano, AU - Bower,Carol, AU - Armstrong,Bruce K, AU - Milne,Elizabeth, Y1 - 2014/06/04/ PY - 2014/6/5/entrez PY - 2014/6/5/pubmed PY - 2015/2/25/medline SP - 800 EP - 9 JF - Nutrition and cancer JO - Nutr Cancer VL - 66 IS - 5 N2 - Childhood brain tumors (CBT) are the second most common childhood cancers, yet their etiology is largely unknown. We investigated whether maternal gestational intake of folate and vitamins B6 and B12 was associated with CBT risk in a nationwide case-control study conducted 2005-2010. Case children 0-14 years were recruited from all 10 Australian pediatric oncology centers. Control children were recruited by national random digit dialing, frequency matched to cases on age, sex, and state of residence. Dietary intake was ascertained using food frequency questionnaires and adjusted for total energy intake. Data from 293 case and 726 control mothers were analyzed using unconditional logistic regression. The odds ratio (OR) for the highest versus lowest tertile of folate intake was 0.70 [95% confidence interval (CI): 0.48, 1.02]. The ORs appeared lower in mothers who drank alcohol during pregnancy (OR = 0.45, 95% CI: 0.22, 0.93), mothers who took folic acid (OR = 0.67, 95% CI: 0.42, 1.06) or B6/B12 supplements (OR = 0.51, 95% CI: 0.25, 1.06) and in children younger than 5 years (OR = 0.50, 95% CI: 0.27, 0.93). These findings are consistent with folate's crucial role in maintenance of genomic integrity and DNA methylation. Dietary intake of B6 and B12 was not associated with risk of CBT. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/24897174/Maternal_dietary_intake_of_folate_and_vitamins_B6_and_B12_during_pregnancy_and_risk_of_childhood_brain_tumors_ L2 - https://www.tandfonline.com/doi/full/10.1080/01635581.2014.916326 DB - PRIME DP - Unbound Medicine ER -