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Nuts in the prevention and treatment of metabolic syndrome.
Am J Clin Nutr. 2014 Jul; 100 Suppl 1:399S-407S.AJ

Abstract

Nuts are rich in many bioactive compounds that can exert beneficial effects on cardiovascular health. We reviewed the evidence relating nut consumption and the metabolic syndrome (MetS) and its components. Nuts reduce the postprandial glycemic response; however, long-term trials of nuts on insulin resistance and glycemic control in diabetic individuals are inconsistent. Epidemiologic studies have shown that nuts may lower the risk of diabetes incidence in women. Few studies have assessed the association between nuts and abdominal obesity, although an inverse association with body mass index and general obesity has been observed. Limited evidence suggests that nuts have a protective effect on blood pressure and endothelial function. Nuts have a cholesterol-lowering effect, but the relation between nuts and hypertriglyceridemia and high-density lipoprotein cholesterol is not well established. A recent pooled analysis of clinical trials showed that nuts are inversely related to triglyceride concentrations only in subjects with hypertriglyceridemia. An inverse association was found between the frequency of nut consumption and the prevalence and the incidence of MetS. Several trials evaluated the effect of nuts on subjects with MetS and found that they may have benefits in some components. Compared with a low-fat diet, a Mediterranean diet enriched with nuts could be beneficial for MetS management. The protective effects on metabolism could be explained by the modulation of inflammation and oxidation. Further trials are needed to clarify the role of nuts in MetS prevention and treatment.

Authors+Show Affiliations

From the Human Nutrition Unit, Saint Joan Hospital, Faculty of Medicine and Health Sciences, Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Reus, Spain (JS-S, MG-F, and MB); CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain (JS-S, MG-F, and MB); and the Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, CA (JS).From the Human Nutrition Unit, Saint Joan Hospital, Faculty of Medicine and Health Sciences, Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Reus, Spain (JS-S, MG-F, and MB); CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain (JS-S, MG-F, and MB); and the Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, CA (JS).From the Human Nutrition Unit, Saint Joan Hospital, Faculty of Medicine and Health Sciences, Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Reus, Spain (JS-S, MG-F, and MB); CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain (JS-S, MG-F, and MB); and the Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, CA (JS).From the Human Nutrition Unit, Saint Joan Hospital, Faculty of Medicine and Health Sciences, Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Reus, Spain (JS-S, MG-F, and MB); CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain (JS-S, MG-F, and MB); and the Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, CA (JS).

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24898227

Citation

Salas-Salvadó, Jordi, et al. "Nuts in the Prevention and Treatment of Metabolic Syndrome." The American Journal of Clinical Nutrition, vol. 100 Suppl 1, 2014, 399S-407S.
Salas-Salvadó J, Guasch-Ferré M, Bulló M, et al. Nuts in the prevention and treatment of metabolic syndrome. Am J Clin Nutr. 2014;100 Suppl 1:399S-407S.
Salas-Salvadó, J., Guasch-Ferré, M., Bulló, M., & Sabaté, J. (2014). Nuts in the prevention and treatment of metabolic syndrome. The American Journal of Clinical Nutrition, 100 Suppl 1, 399S-407S. https://doi.org/10.3945/ajcn.113.071530
Salas-Salvadó J, et al. Nuts in the Prevention and Treatment of Metabolic Syndrome. Am J Clin Nutr. 2014;100 Suppl 1:399S-407S. PubMed PMID: 24898227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nuts in the prevention and treatment of metabolic syndrome. AU - Salas-Salvadó,Jordi, AU - Guasch-Ferré,Marta, AU - Bulló,Mònica, AU - Sabaté,Joan, Y1 - 2014/06/04/ PY - 2014/6/6/entrez PY - 2014/6/6/pubmed PY - 2015/5/2/medline SP - 399S EP - 407S JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 100 Suppl 1 N2 - Nuts are rich in many bioactive compounds that can exert beneficial effects on cardiovascular health. We reviewed the evidence relating nut consumption and the metabolic syndrome (MetS) and its components. Nuts reduce the postprandial glycemic response; however, long-term trials of nuts on insulin resistance and glycemic control in diabetic individuals are inconsistent. Epidemiologic studies have shown that nuts may lower the risk of diabetes incidence in women. Few studies have assessed the association between nuts and abdominal obesity, although an inverse association with body mass index and general obesity has been observed. Limited evidence suggests that nuts have a protective effect on blood pressure and endothelial function. Nuts have a cholesterol-lowering effect, but the relation between nuts and hypertriglyceridemia and high-density lipoprotein cholesterol is not well established. A recent pooled analysis of clinical trials showed that nuts are inversely related to triglyceride concentrations only in subjects with hypertriglyceridemia. An inverse association was found between the frequency of nut consumption and the prevalence and the incidence of MetS. Several trials evaluated the effect of nuts on subjects with MetS and found that they may have benefits in some components. Compared with a low-fat diet, a Mediterranean diet enriched with nuts could be beneficial for MetS management. The protective effects on metabolism could be explained by the modulation of inflammation and oxidation. Further trials are needed to clarify the role of nuts in MetS prevention and treatment. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/24898227/Nuts_in_the_prevention_and_treatment_of_metabolic_syndrome_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.113.071530 DB - PRIME DP - Unbound Medicine ER -