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Serum 25-hydroxyvitamin d and the onset of late-life depressive mood in older men and women: the Pro.V.A. study.
J Gerontol A Biol Sci Med Sci. 2014 Dec; 69(12):1554-61.JG

Abstract

INTRODUCTION

Biological evidence suggests that vitamin D might be involved in regulating mood. The relationship between 25-hydroxyvitamin D (25OHD) and the onset of depressive symptoms was examined over a 4.4-year follow-up in a sample of older adults.

METHODS

This research was part of the Progetto Veneto Anziani (Pro.V.A.), an Italian population-based cohort study on a total of 1,039 women and 636 men aged 65 and older. Serum 25OHD levels were measured at baseline. Depressive symptoms were assessed with the Geriatric Depression Scale (GDS) at the baseline and during the follow-up. Analyses were adjusted for relevant confounders, including health and performance status.

RESULTS

25OHD levels correlated inversely with baseline GDS scores, but only in women. After controlling for confounders, women deficient in vitamin D (25OHD < 50 nmol/L) had higher GDS scores than those who were replete (25OHD > 75 nmol/L), with mean [SE] GDS scores: 9.57 [0.37] vs 8.31 [0.31], respectively, p = .02. In men, the relationship between 25OHD levels and baseline GDS scores was no longer significant after controlling for covariates. Adjusted hazard ratios and 95% confidence intervals for incident depression in participants who were vitamin D deficient vs replete were not statistically significant (hazard ratio: 0.74, 95% confidence interval [0.47-1.16] in women; hazard ratio: 0.96 95% confidence interval [0.45-2.06] in men).

CONCLUSION

Although an independent inverse association between 25OHD levels and GDS scores emerged for women on cross-sectional analysis, vitamin D deficiency showed no direct effect on the onset of late-life depressive symptoms in our prospectively studied population. Further studies are warranted to clarify the potential influence of vitamin D on psychological health.

Authors+Show Affiliations

Department of Medical and Surgical Sciences, Department of Medicine, Geriatrics Division, elenadebora.toffanello@sanita.padova.it.Department of Medical and Surgical Sciences, Department of Medicine, Geriatrics Division.Department of Medical and Surgical Sciences, Department of Medicine, Geriatrics Division.Department of Environmental Medicine and Public Health, and.Department of Medical and Surgical Sciences, University of Padua, Padova, Italy. National Research Council, Aging Branch, Institute of Neuroscience, Padova, Italy.Department of Medical and Surgical Sciences, Department of Medicine, Geriatrics Division.Department of Medical and Surgical Sciences, University of Padua, Padova, Italy.Department of Medical and Surgical Sciences, University of Padua, Padova, Italy.Dipartimento Socio Sanitario dei Colli, Azienda Unità Locale Socio Sanitaria, Padova, Italy.Internal Medicine Division, Azienda Ospedaliera, Padova, Italy.National Research Council, Aging Branch, Institute of Neuroscience, Padova, Italy.Department of Medical and Surgical Sciences, Department of Medicine, Geriatrics Division, National Research Council, Aging Branch, Institute of Neuroscience, Padova, Italy.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Observational Study
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24899526

Citation

Toffanello, Elena D., et al. "Serum 25-hydroxyvitamin D and the Onset of Late-life Depressive Mood in Older Men and Women: the Pro.V.A. Study." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 69, no. 12, 2014, pp. 1554-61.
Toffanello ED, Sergi G, Veronese N, et al. Serum 25-hydroxyvitamin d and the onset of late-life depressive mood in older men and women: the Pro.V.A. study. J Gerontol A Biol Sci Med Sci. 2014;69(12):1554-61.
Toffanello, E. D., Sergi, G., Veronese, N., Perissinotto, E., Zambon, S., Coin, A., Sartori, L., Musacchio, E., Corti, M. C., Baggio, G., Crepaldi, G., & Manzato, E. (2014). Serum 25-hydroxyvitamin d and the onset of late-life depressive mood in older men and women: the Pro.V.A. study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 69(12), 1554-61. https://doi.org/10.1093/gerona/glu081
Toffanello ED, et al. Serum 25-hydroxyvitamin D and the Onset of Late-life Depressive Mood in Older Men and Women: the Pro.V.A. Study. J Gerontol A Biol Sci Med Sci. 2014;69(12):1554-61. PubMed PMID: 24899526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin d and the onset of late-life depressive mood in older men and women: the Pro.V.A. study. AU - Toffanello,Elena D, AU - Sergi,Giuseppe, AU - Veronese,Nicola, AU - Perissinotto,Egle, AU - Zambon,Sabina, AU - Coin,Alessandra, AU - Sartori,Leonardo, AU - Musacchio,Estella, AU - Corti,Maria-Chiara, AU - Baggio,Giovannella, AU - Crepaldi,Gaetano, AU - Manzato,Enzo, Y1 - 2014/06/04/ PY - 2014/6/6/entrez PY - 2014/6/6/pubmed PY - 2015/1/21/medline KW - 25-Hydroxyvitamin D KW - Community-dwelling adults. KW - Depression KW - Elderly SP - 1554 EP - 61 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. VL - 69 IS - 12 N2 - INTRODUCTION: Biological evidence suggests that vitamin D might be involved in regulating mood. The relationship between 25-hydroxyvitamin D (25OHD) and the onset of depressive symptoms was examined over a 4.4-year follow-up in a sample of older adults. METHODS: This research was part of the Progetto Veneto Anziani (Pro.V.A.), an Italian population-based cohort study on a total of 1,039 women and 636 men aged 65 and older. Serum 25OHD levels were measured at baseline. Depressive symptoms were assessed with the Geriatric Depression Scale (GDS) at the baseline and during the follow-up. Analyses were adjusted for relevant confounders, including health and performance status. RESULTS: 25OHD levels correlated inversely with baseline GDS scores, but only in women. After controlling for confounders, women deficient in vitamin D (25OHD < 50 nmol/L) had higher GDS scores than those who were replete (25OHD > 75 nmol/L), with mean [SE] GDS scores: 9.57 [0.37] vs 8.31 [0.31], respectively, p = .02. In men, the relationship between 25OHD levels and baseline GDS scores was no longer significant after controlling for covariates. Adjusted hazard ratios and 95% confidence intervals for incident depression in participants who were vitamin D deficient vs replete were not statistically significant (hazard ratio: 0.74, 95% confidence interval [0.47-1.16] in women; hazard ratio: 0.96 95% confidence interval [0.45-2.06] in men). CONCLUSION: Although an independent inverse association between 25OHD levels and GDS scores emerged for women on cross-sectional analysis, vitamin D deficiency showed no direct effect on the onset of late-life depressive symptoms in our prospectively studied population. Further studies are warranted to clarify the potential influence of vitamin D on psychological health. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/24899526/Serum_25_hydroxyvitamin_d_and_the_onset_of_late_life_depressive_mood_in_older_men_and_women:_the_Pro_V_A__study_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glu081 DB - PRIME DP - Unbound Medicine ER -