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Vitamin K nutritional status and undercarboxylated osteocalcin in postmenopausal osteoporotic women treated with bisphosphonates.
Asia Pac J Clin Nutr 2014; 23(2):256-62AP

Abstract

Serum undercarboxylated osteocalcin (ucOC) is an index of vitamin K nutritional status in treatment-naive postmenopausal osteoporotic women. The purpose of the present study was to reveal the association between vitamin K nutritional status and serum ucOC concentrations in postmenopausal osteoporotic women taking bisphosphonates. Eighty-six postmenopausal women with osteoporosis (age range: 47-90 years) initiated bisphosphonate treatment. Vitamin K nutritional status was evaluated using a simple vitamin K-intake questionnaire and serum ucOC concentrations were measured after 6 months of treatment. The patients were divided into two groups according to the simple vitamin K-intake questionnaire score: a low vitamin K-intake (score <40) group (n=67) and a normal vitamin K-intake (score >=40) group (n=19). There were no significant differences between the groups in baseline parameters including age, height, body weight, body mass index, serum alkaline phosphatase (ALP), urinary cross-linked N-terminal telopeptides of type I collagen (NTX), and changes in serum ALP and urinary NTX concentrations during the 6-month treatment period. However, the mean serum ucOC concentration after 6 months of treatment was significantly higher in the low vitamin K-intake group (2.79 ng/mL) than in the normal vitamin K-intake group (2.20 ng/mL). These results suggest that 78% of postmenopausal osteoporotic women treated with bisphosphonates may have vitamin K deficiency as indicated by low vitamin K-intake and high serum ucOC concentrations, despite having a similar reduction in bone turnover to women who have normal vitamin K-intake.

Authors+Show Affiliations

Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. jiwamoto@a8.keio.jp.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24901095

Citation

Iwamoto, Jun, et al. "Vitamin K Nutritional Status and Undercarboxylated Osteocalcin in Postmenopausal Osteoporotic Women Treated With Bisphosphonates." Asia Pacific Journal of Clinical Nutrition, vol. 23, no. 2, 2014, pp. 256-62.
Iwamoto J, Takada T, Sato Y. Vitamin K nutritional status and undercarboxylated osteocalcin in postmenopausal osteoporotic women treated with bisphosphonates. Asia Pac J Clin Nutr. 2014;23(2):256-62.
Iwamoto, J., Takada, T., & Sato, Y. (2014). Vitamin K nutritional status and undercarboxylated osteocalcin in postmenopausal osteoporotic women treated with bisphosphonates. Asia Pacific Journal of Clinical Nutrition, 23(2), pp. 256-62. doi:10.6133/apjcn.2014.23.2.15.
Iwamoto J, Takada T, Sato Y. Vitamin K Nutritional Status and Undercarboxylated Osteocalcin in Postmenopausal Osteoporotic Women Treated With Bisphosphonates. Asia Pac J Clin Nutr. 2014;23(2):256-62. PubMed PMID: 24901095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin K nutritional status and undercarboxylated osteocalcin in postmenopausal osteoporotic women treated with bisphosphonates. AU - Iwamoto,Jun, AU - Takada,Tetsuya, AU - Sato,Yoshihiro, PY - 2014/6/6/entrez PY - 2014/6/6/pubmed PY - 2014/8/1/medline SP - 256 EP - 62 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 23 IS - 2 N2 - Serum undercarboxylated osteocalcin (ucOC) is an index of vitamin K nutritional status in treatment-naive postmenopausal osteoporotic women. The purpose of the present study was to reveal the association between vitamin K nutritional status and serum ucOC concentrations in postmenopausal osteoporotic women taking bisphosphonates. Eighty-six postmenopausal women with osteoporosis (age range: 47-90 years) initiated bisphosphonate treatment. Vitamin K nutritional status was evaluated using a simple vitamin K-intake questionnaire and serum ucOC concentrations were measured after 6 months of treatment. The patients were divided into two groups according to the simple vitamin K-intake questionnaire score: a low vitamin K-intake (score <40) group (n=67) and a normal vitamin K-intake (score >=40) group (n=19). There were no significant differences between the groups in baseline parameters including age, height, body weight, body mass index, serum alkaline phosphatase (ALP), urinary cross-linked N-terminal telopeptides of type I collagen (NTX), and changes in serum ALP and urinary NTX concentrations during the 6-month treatment period. However, the mean serum ucOC concentration after 6 months of treatment was significantly higher in the low vitamin K-intake group (2.79 ng/mL) than in the normal vitamin K-intake group (2.20 ng/mL). These results suggest that 78% of postmenopausal osteoporotic women treated with bisphosphonates may have vitamin K deficiency as indicated by low vitamin K-intake and high serum ucOC concentrations, despite having a similar reduction in bone turnover to women who have normal vitamin K-intake. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/24901095/Vitamin_K_nutritional_status_and_undercarboxylated_osteocalcin_in_postmenopausal_osteoporotic_women_treated_with_bisphosphonates_ L2 - http://apjcn.nhri.org.tw/server/APJCN/23/2/256.pdf DB - PRIME DP - Unbound Medicine ER -