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Plasma homocysteine concentrations in acute and convalescent changes of central retinal vein occlusion in a Chinese population.
Invest Ophthalmol Vis Sci 2014; 55(7):4057-62IO

Abstract

PURPOSE

Homocysteine is a potential risk factor for central retinal vein occlusion (CRVO), but this remains controversial. We measured fasting total plasma homocysteine (tHcy) concentrations immediately after CRVO and in the convalescent period to investigate this controversy.

METHODS

We measured fasting tHcy concentrations in 36 consecutive patients with CRVO within three days; and at 1, 3, and 6 months after CRVO; and once in 36 control subjects. The vitamin B12 and folate levels, and the presence of C677T MTHFR polymorphisms, were analyzed in all patients and controls.

RESULTS

Median tHcy concentrations were not significantly higher than in matched control subjects in the acute phase of CRVO (9.66 [10.75 ± 4.09] vs. 9.25 [9.96 ± 4.02] μmol/L, P = 0.371) and 1 month after CRVO (P = 0.119). However, tHcy levels increased significantly in the convalescent period and were significantly higher than in control subjects at 3 CRVO (P = 0.010) and 6 (P < 0.001) months after CRVO. Furthermore, tHcy levels of the ischemic CRVO patients at 6 months after CRVO were significantly higher than in nonischemic CRVO patients (P = 0.028). However, these observations did not appear to be explained by alteration in serum folate, vitamin B12 concentrations, and the MTHFR C677T genotype.

CONCLUSIONS

The tHcy levels are not immediately elevated after CRVO, but increase in the convalescent period. These data do not support the hypothesis that raised tHcy concentrations are independent risk factor for CRVO. Instead, it is possible that elevated tHcy levels may be caused by the disease process itself.

Authors+Show Affiliations

Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China.Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China.Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital, Tianjin, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24906854

Citation

Dong, Ning, et al. "Plasma Homocysteine Concentrations in Acute and Convalescent Changes of Central Retinal Vein Occlusion in a Chinese Population." Investigative Ophthalmology & Visual Science, vol. 55, no. 7, 2014, pp. 4057-62.
Dong N, Xu B, Tang X. Plasma homocysteine concentrations in acute and convalescent changes of central retinal vein occlusion in a Chinese population. Invest Ophthalmol Vis Sci. 2014;55(7):4057-62.
Dong, N., Xu, B., & Tang, X. (2014). Plasma homocysteine concentrations in acute and convalescent changes of central retinal vein occlusion in a Chinese population. Investigative Ophthalmology & Visual Science, 55(7), pp. 4057-62. doi:10.1167/iovs.14-14226.
Dong N, Xu B, Tang X. Plasma Homocysteine Concentrations in Acute and Convalescent Changes of Central Retinal Vein Occlusion in a Chinese Population. Invest Ophthalmol Vis Sci. 2014 Jun 6;55(7):4057-62. PubMed PMID: 24906854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma homocysteine concentrations in acute and convalescent changes of central retinal vein occlusion in a Chinese population. AU - Dong,Ning, AU - Xu,Bing, AU - Tang,Xin, Y1 - 2014/06/06/ PY - 2014/6/8/entrez PY - 2014/6/8/pubmed PY - 2014/9/10/medline KW - MTHFR C677T KW - acute phase KW - central retinal vein occlusion KW - convalescent period KW - total plasma homocysteine SP - 4057 EP - 62 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 55 IS - 7 N2 - PURPOSE: Homocysteine is a potential risk factor for central retinal vein occlusion (CRVO), but this remains controversial. We measured fasting total plasma homocysteine (tHcy) concentrations immediately after CRVO and in the convalescent period to investigate this controversy. METHODS: We measured fasting tHcy concentrations in 36 consecutive patients with CRVO within three days; and at 1, 3, and 6 months after CRVO; and once in 36 control subjects. The vitamin B12 and folate levels, and the presence of C677T MTHFR polymorphisms, were analyzed in all patients and controls. RESULTS: Median tHcy concentrations were not significantly higher than in matched control subjects in the acute phase of CRVO (9.66 [10.75 ± 4.09] vs. 9.25 [9.96 ± 4.02] μmol/L, P = 0.371) and 1 month after CRVO (P = 0.119). However, tHcy levels increased significantly in the convalescent period and were significantly higher than in control subjects at 3 CRVO (P = 0.010) and 6 (P < 0.001) months after CRVO. Furthermore, tHcy levels of the ischemic CRVO patients at 6 months after CRVO were significantly higher than in nonischemic CRVO patients (P = 0.028). However, these observations did not appear to be explained by alteration in serum folate, vitamin B12 concentrations, and the MTHFR C677T genotype. CONCLUSIONS: The tHcy levels are not immediately elevated after CRVO, but increase in the convalescent period. These data do not support the hypothesis that raised tHcy concentrations are independent risk factor for CRVO. Instead, it is possible that elevated tHcy levels may be caused by the disease process itself. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/24906854/Plasma_homocysteine_concentrations_in_acute_and_convalescent_changes_of_central_retinal_vein_occlusion_in_a_Chinese_population_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-14226 DB - PRIME DP - Unbound Medicine ER -