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Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers.
Colloids Surf B Biointerfaces. 2014 Aug 01; 120:125-31.CS

Abstract

Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. (1)H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC.

Authors+Show Affiliations

Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey; UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.Gazi University, Life Sciences Application and Research Center, Ankara 06830, Turkey.Gazi University, Life Sciences Application and Research Center, Ankara 06830, Turkey; Gazi University, Polatlı Science and Literature Faculty, Ankara 06900, Turkey.Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey; UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey. Electronic address: tamer@unam.bilkent.edu.tr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24907582

Citation

Aytac, Zeynep, et al. "Release and Antibacterial Activity of Allyl Isothiocyanate/β-cyclodextrin Complex Encapsulated in Electrospun Nanofibers." Colloids and Surfaces. B, Biointerfaces, vol. 120, 2014, pp. 125-31.
Aytac Z, Dogan SY, Tekinay T, et al. Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers. Colloids Surf B Biointerfaces. 2014;120:125-31.
Aytac, Z., Dogan, S. Y., Tekinay, T., & Uyar, T. (2014). Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers. Colloids and Surfaces. B, Biointerfaces, 120, 125-31. https://doi.org/10.1016/j.colsurfb.2014.04.006
Aytac Z, et al. Release and Antibacterial Activity of Allyl Isothiocyanate/β-cyclodextrin Complex Encapsulated in Electrospun Nanofibers. Colloids Surf B Biointerfaces. 2014 Aug 1;120:125-31. PubMed PMID: 24907582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers. AU - Aytac,Zeynep, AU - Dogan,Sema Y, AU - Tekinay,Turgay, AU - Uyar,Tamer, Y1 - 2014/05/22/ PY - 2013/12/21/received PY - 2014/03/19/revised PY - 2014/04/13/accepted PY - 2014/6/8/entrez PY - 2014/6/8/pubmed PY - 2015/2/13/medline KW - Allyl isothiocyanate KW - Antibacterial activity KW - Electrospinning KW - Nanofibers KW - Release KW - β-Cyclodextrin SP - 125 EP - 31 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 120 N2 - Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. (1)H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/24907582/Release_and_antibacterial_activity_of_allyl_isothiocyanate/β_cyclodextrin_complex_encapsulated_in_electrospun_nanofibers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(14)00204-5 DB - PRIME DP - Unbound Medicine ER -