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Comparative evaluation of acute and chronic toxicities of CuO nanoparticles and bulk using Daphnia magna and Vibrio fischeri.
Sci Total Environ. 2014 Aug 15; 490:807-14.ST

Abstract

Copper oxide (CuO) has various applications, as highlighted by the incorporation of this compound as a biocide of antifouling paints for coating ships and offshore oil platforms. The objective of this study was to evaluate and compare the aquatic toxicity of CuO nanoparticles (NPs) and microparticles (MPs) through acute and chronic toxicity tests with the freshwater microcrustacean Daphnia magna and an acute toxicity test with the bioluminescent marine bacteria Vibrio fischeri. Acute toxicity results for D. magna in tests with CuO NPs (EC50, 48 h=22 mg L(-1)) were ten times higher than those for tests with CuO MPs (EC50, 48 h=223.6 mg L(-1)). In both periods of exposure of V. fischeri, the CuO NPs (EC50, 15m 248±56.39 - equivalent to 12.40%; EC50, 30 m 257.6±30.8 mg L(-1) - equivalent to 12.88%) were more toxic than the CuO MPs (EC50, 15m 2404.6±277.4 - equivalent to 60.10%; EC50, 30 m 1472.9±244.7 mg L(-1) - equivalent to 36.82%). In chronic toxicity tests, both forms of CuO showed significant effects (p<0.05) on the growth and reproduction parameters of the D. magna relative to the control. Additionally, morphological changes, such as lack of apical spine development and malformed carapaces in D. magna, were observed for organisms after the chronic test. The toxicity results demonstrate that CuO NPs have a higher level of toxicity than CuO MPs, emphasizing the need for comparative toxicological studies to correctly classify these two forms of CuO with identical CAS registration numbers.

Authors+Show Affiliations

Laboratório de Toxicologia Ambiental, LABTOX, Departamento de Engenharia Sanitária e Ambiental, Universidade Federal de Santa Catarina, Campus Universitário, CEP: 88040-970 Florianópolis, SC, Brazil.Laboratório de Toxicologia Ambiental, LABTOX, Departamento de Engenharia Sanitária e Ambiental, Universidade Federal de Santa Catarina, Campus Universitário, CEP: 88040-970 Florianópolis, SC, Brazil.Laboratório de Biologia Celular Vegetal, Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, CP 476 Florianópolis, SC, Brazil.Laboratório de Toxicologia Ambiental, LABTOX, Departamento de Engenharia Sanitária e Ambiental, Universidade Federal de Santa Catarina, Campus Universitário, CEP: 88040-970 Florianópolis, SC, Brazil. Electronic address: william.g.matias@ufsc.br.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24907615

Citation

Rossetto, Ana Letícia de O F., et al. "Comparative Evaluation of Acute and Chronic Toxicities of CuO Nanoparticles and Bulk Using Daphnia Magna and Vibrio Fischeri." The Science of the Total Environment, vol. 490, 2014, pp. 807-14.
Rossetto AL, Melegari SP, Ouriques LC, et al. Comparative evaluation of acute and chronic toxicities of CuO nanoparticles and bulk using Daphnia magna and Vibrio fischeri. Sci Total Environ. 2014;490:807-14.
Rossetto, A. L., Melegari, S. P., Ouriques, L. C., & Matias, W. G. (2014). Comparative evaluation of acute and chronic toxicities of CuO nanoparticles and bulk using Daphnia magna and Vibrio fischeri. The Science of the Total Environment, 490, 807-14. https://doi.org/10.1016/j.scitotenv.2014.05.056
Rossetto AL, et al. Comparative Evaluation of Acute and Chronic Toxicities of CuO Nanoparticles and Bulk Using Daphnia Magna and Vibrio Fischeri. Sci Total Environ. 2014 Aug 15;490:807-14. PubMed PMID: 24907615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative evaluation of acute and chronic toxicities of CuO nanoparticles and bulk using Daphnia magna and Vibrio fischeri. AU - Rossetto,Ana Letícia de O F, AU - Melegari,Silvia Pedroso, AU - Ouriques,Luciane Cristina, AU - Matias,William Gerson, Y1 - 2014/06/05/ PY - 2013/10/01/received PY - 2014/05/07/revised PY - 2014/05/07/accepted PY - 2014/6/8/entrez PY - 2014/6/8/pubmed PY - 2014/12/23/medline KW - Chronic test KW - Copper oxide microparticle KW - Copper oxide nanoparticle KW - Daphnia magna KW - Vibrio fischeri SP - 807 EP - 14 JF - The Science of the total environment JO - Sci Total Environ VL - 490 N2 - Copper oxide (CuO) has various applications, as highlighted by the incorporation of this compound as a biocide of antifouling paints for coating ships and offshore oil platforms. The objective of this study was to evaluate and compare the aquatic toxicity of CuO nanoparticles (NPs) and microparticles (MPs) through acute and chronic toxicity tests with the freshwater microcrustacean Daphnia magna and an acute toxicity test with the bioluminescent marine bacteria Vibrio fischeri. Acute toxicity results for D. magna in tests with CuO NPs (EC50, 48 h=22 mg L(-1)) were ten times higher than those for tests with CuO MPs (EC50, 48 h=223.6 mg L(-1)). In both periods of exposure of V. fischeri, the CuO NPs (EC50, 15m 248±56.39 - equivalent to 12.40%; EC50, 30 m 257.6±30.8 mg L(-1) - equivalent to 12.88%) were more toxic than the CuO MPs (EC50, 15m 2404.6±277.4 - equivalent to 60.10%; EC50, 30 m 1472.9±244.7 mg L(-1) - equivalent to 36.82%). In chronic toxicity tests, both forms of CuO showed significant effects (p<0.05) on the growth and reproduction parameters of the D. magna relative to the control. Additionally, morphological changes, such as lack of apical spine development and malformed carapaces in D. magna, were observed for organisms after the chronic test. The toxicity results demonstrate that CuO NPs have a higher level of toxicity than CuO MPs, emphasizing the need for comparative toxicological studies to correctly classify these two forms of CuO with identical CAS registration numbers. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/24907615/Comparative_evaluation_of_acute_and_chronic_toxicities_of_CuO_nanoparticles_and_bulk_using_Daphnia_magna_and_Vibrio_fischeri_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(14)00736-0 DB - PRIME DP - Unbound Medicine ER -