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Synthesis, characterization and foaming of PHEA-PLLA, a new graft copolymer for biomedical engineering.

Abstract

In this study a chemical grafting procedure was set up in order to link high molecular weight poly L-lactic acid (PLLA) chains to the hydrophilic α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) backbone. A graft copolymer named PHEA-g-PLLA (or simply PHEA-PLLA) was obtained bearing a degree of derivatization of 1.0 mol.% of PLLA as grafted chain. This new hybrid derivative offers both the opportune crystallinity necessary for the production of scaffolds trough a thermally induced phase separation (TIPS) technique and the proper chemical reactivity to perform further functionalizations with bio-effectors and drugs. PHEA-PLLA porous scaffolds for tissue engineering applications were successfully obtained via TIPS and characterized. Structures with an open porosity and a good level of interconnection were detected. As the applicability of the scaffold is mainly dependent on its pore size, preliminary studies about the mechanisms governing scaffold's pore diameter were carried out.

Authors+Show Affiliations

Department of Civil, Environmental, Aerospace, Materials Engineering, University of Palermo, 90142, Palermo, Italy. Electronic address: francesco.carfipavia@unipa.it.Department of Civil, Environmental, Aerospace, Materials Engineering, University of Palermo, 90142, Palermo, Italy.Department of Civil, Environmental, Aerospace, Materials Engineering, University of Palermo, 90142, Palermo, Italy.Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sezione di Chimica e Tecnologie Farmaceutiche, University of Palermo, Italy.Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sezione di Chimica e Tecnologie Farmaceutiche, University of Palermo, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24907764

Citation

Carfì Pavia, Francesco, et al. "Synthesis, Characterization and Foaming of PHEA-PLLA, a New Graft Copolymer for Biomedical Engineering." Materials Science & Engineering. C, Materials for Biological Applications, vol. 41, 2014, pp. 301-8.
Carfì Pavia F, La Carrubba V, Brucato V, et al. Synthesis, characterization and foaming of PHEA-PLLA, a new graft copolymer for biomedical engineering. Mater Sci Eng C Mater Biol Appl. 2014;41:301-8.
Carfì Pavia, F., La Carrubba, V., Brucato, V., Palumbo, F. S., & Giammona, G. (2014). Synthesis, characterization and foaming of PHEA-PLLA, a new graft copolymer for biomedical engineering. Materials Science & Engineering. C, Materials for Biological Applications, 41, pp. 301-8. doi:10.1016/j.msec.2014.04.045.
Carfì Pavia F, et al. Synthesis, Characterization and Foaming of PHEA-PLLA, a New Graft Copolymer for Biomedical Engineering. Mater Sci Eng C Mater Biol Appl. 2014 Aug 1;41:301-8. PubMed PMID: 24907764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis, characterization and foaming of PHEA-PLLA, a new graft copolymer for biomedical engineering. AU - Carfì Pavia,Francesco, AU - La Carrubba,Vincenzo, AU - Brucato,Valerio, AU - Palumbo,Fabio Salvatore, AU - Giammona,Gaetano, Y1 - 2014/05/02/ PY - 2013/10/29/received PY - 2014/03/05/revised PY - 2014/04/18/accepted PY - 2014/6/9/entrez PY - 2014/6/9/pubmed PY - 2015/1/28/medline KW - Poly-L-lactic acid KW - Polymer graft KW - Scaffold KW - Thermally induced phase separation SP - 301 EP - 8 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 41 N2 - In this study a chemical grafting procedure was set up in order to link high molecular weight poly L-lactic acid (PLLA) chains to the hydrophilic α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) backbone. A graft copolymer named PHEA-g-PLLA (or simply PHEA-PLLA) was obtained bearing a degree of derivatization of 1.0 mol.% of PLLA as grafted chain. This new hybrid derivative offers both the opportune crystallinity necessary for the production of scaffolds trough a thermally induced phase separation (TIPS) technique and the proper chemical reactivity to perform further functionalizations with bio-effectors and drugs. PHEA-PLLA porous scaffolds for tissue engineering applications were successfully obtained via TIPS and characterized. Structures with an open porosity and a good level of interconnection were detected. As the applicability of the scaffold is mainly dependent on its pore size, preliminary studies about the mechanisms governing scaffold's pore diameter were carried out. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/24907764/Synthesis_characterization_and_foaming_of_PHEA_PLLA_a_new_graft_copolymer_for_biomedical_engineering_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-4931(14)00237-9 DB - PRIME DP - Unbound Medicine ER -