Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss.
BACKGROUND & AIMSOsteoporosis is a chief complication in patients with anorexia nervosa. Serum levels of undercarboxylated osteocalcin reflect serum and bone vitamin K deficiency. We investigated vitamin K status in patients with anorexia nervosa to help establish prevention and treatment recommendations for osteoporosis.
METHODSFifty-four female amenorrheic patients with anorexia nervosa (29 restricting-type and 25 binge eating/purging type) (age, 28.0 (26.7-31.1) (mean (95% CI)) years; body mass index, 14.8 (14.1-15.5) kg/m(2), duration of illness; 107.3 (88.5-126.0) months) and 15 age-matched healthy females were included in this study. We measured serum levels of undercarboxylated osteocalcin, biochemical and nutritional markers, and bone metabolic markers. Dietary vitamin K intake was evaluated by a questionnaire.
RESULTSLumbar bone mineral density and T-scores in patients with anorexia nervosa were 0.756 (0.721-0.790) g/cm(2) and -2.4 (-2.1 to -2.7), respectively, indicating bone loss. Serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa were significantly higher than those of controls. The 17% of restricting type and 40% of binge eating/purging type anorexia nervosa patients, serum levels of undercarboxylated osteocalcin were higher than 4.5 ng/ml and were diagnosed with vitamin K deficiency. Serum levels of undercarboxylated osteocalcin correlated significantly and negatively with vitamin K intake in patients with anorexia nervosa.
CONCLUSIONSPatients with anorexia nervosa had vitamin K deficiency. Since a supplement of vitamin K might be effective for maintaining bone quality, we provide recommendations regarding vitamin K intake for prevention and treatment of osteoporosis in patients with AN.
Division of Endocrinology and Metabolism, Saitama Sekishinkai Hospital, Saitama, Japan.,
Health Service Center, National Graduate Institute For Policy Studies, Tokyo, Japan; Institute of Women's Health, Tokyo Women's Medical University, Tokyo, Japan. Electronic address: email@example.com.,
Division of Endocrinology and Metabolism, Saitama Sekishinkai Hospital, Saitama, Japan.
Department of Internal Medicine, Nagai Hitachinomori Hospital, Ibaraki, Japan.
Body Mass Index
Bone Diseases, Metabolic
Bone and Bones
Surveys and Questionnaires
Vitamin K Deficiency
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't