Tags

Type your tag names separated by a space and hit enter

Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss.

Abstract

BACKGROUND & AIMS

Osteoporosis is a chief complication in patients with anorexia nervosa. Serum levels of undercarboxylated osteocalcin reflect serum and bone vitamin K deficiency. We investigated vitamin K status in patients with anorexia nervosa to help establish prevention and treatment recommendations for osteoporosis.

METHODS

Fifty-four female amenorrheic patients with anorexia nervosa (29 restricting-type and 25 binge eating/purging type) (age, 28.0 (26.7-31.1) (mean (95% CI)) years; body mass index, 14.8 (14.1-15.5) kg/m(2), duration of illness; 107.3 (88.5-126.0) months) and 15 age-matched healthy females were included in this study. We measured serum levels of undercarboxylated osteocalcin, biochemical and nutritional markers, and bone metabolic markers. Dietary vitamin K intake was evaluated by a questionnaire.

RESULTS

Lumbar bone mineral density and T-scores in patients with anorexia nervosa were 0.756 (0.721-0.790) g/cm(2) and -2.4 (-2.1 to -2.7), respectively, indicating bone loss. Serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa were significantly higher than those of controls. The 17% of restricting type and 40% of binge eating/purging type anorexia nervosa patients, serum levels of undercarboxylated osteocalcin were higher than 4.5 ng/ml and were diagnosed with vitamin K deficiency. Serum levels of undercarboxylated osteocalcin correlated significantly and negatively with vitamin K intake in patients with anorexia nervosa.

CONCLUSIONS

Patients with anorexia nervosa had vitamin K deficiency. Since a supplement of vitamin K might be effective for maintaining bone quality, we provide recommendations regarding vitamin K intake for prevention and treatment of osteoporosis in patients with AN.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Endocrinology and Metabolism, Saitama Sekishinkai Hospital, Saitama, Japan.

    ,

    Health Service Center, National Graduate Institute For Policy Studies, Tokyo, Japan; Institute of Women's Health, Tokyo Women's Medical University, Tokyo, Japan. Electronic address: marihs@grips.ac.jp.

    ,

    Division of Endocrinology and Metabolism, Saitama Sekishinkai Hospital, Saitama, Japan.

    Department of Internal Medicine, Nagai Hitachinomori Hospital, Ibaraki, Japan.

    Source

    MeSH

    Adult
    Anorexia Nervosa
    Biomarkers
    Body Mass Index
    Bone Density
    Bone Diseases, Metabolic
    Bone and Bones
    Bulimia Nervosa
    Case-Control Studies
    Female
    Humans
    Nutritional Status
    Osteocalcin
    Osteoporosis
    Surveys and Questionnaires
    Vitamin K
    Vitamin K Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24909585

    Citation

    Urano, Ayako, et al. "Vitamin K Deficiency Evaluated By Serum Levels of Undercarboxylated Osteocalcin in Patients With Anorexia Nervosa With Bone Loss." Clinical Nutrition (Edinburgh, Scotland), vol. 34, no. 3, 2015, pp. 443-8.
    Urano A, Hotta M, Ohwada R, et al. Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss. Clin Nutr. 2015;34(3):443-8.
    Urano, A., Hotta, M., Ohwada, R., & Araki, M. (2015). Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss. Clinical Nutrition (Edinburgh, Scotland), 34(3), pp. 443-8. doi:10.1016/j.clnu.2014.04.016.
    Urano A, et al. Vitamin K Deficiency Evaluated By Serum Levels of Undercarboxylated Osteocalcin in Patients With Anorexia Nervosa With Bone Loss. Clin Nutr. 2015;34(3):443-8. PubMed PMID: 24909585.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss. AU - Urano,Ayako, AU - Hotta,Mari, AU - Ohwada,Rina, AU - Araki,Mariko, Y1 - 2014/05/28/ PY - 2013/08/26/received PY - 2014/04/10/revised PY - 2014/04/23/accepted PY - 2014/6/10/entrez PY - 2014/6/10/pubmed PY - 2016/2/24/medline KW - Anorexia nervosa KW - Osteoporosis KW - Undercarboxylated osteocalcin KW - Vitamin K SP - 443 EP - 8 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 34 IS - 3 N2 - BACKGROUND & AIMS: Osteoporosis is a chief complication in patients with anorexia nervosa. Serum levels of undercarboxylated osteocalcin reflect serum and bone vitamin K deficiency. We investigated vitamin K status in patients with anorexia nervosa to help establish prevention and treatment recommendations for osteoporosis. METHODS: Fifty-four female amenorrheic patients with anorexia nervosa (29 restricting-type and 25 binge eating/purging type) (age, 28.0 (26.7-31.1) (mean (95% CI)) years; body mass index, 14.8 (14.1-15.5) kg/m(2), duration of illness; 107.3 (88.5-126.0) months) and 15 age-matched healthy females were included in this study. We measured serum levels of undercarboxylated osteocalcin, biochemical and nutritional markers, and bone metabolic markers. Dietary vitamin K intake was evaluated by a questionnaire. RESULTS: Lumbar bone mineral density and T-scores in patients with anorexia nervosa were 0.756 (0.721-0.790) g/cm(2) and -2.4 (-2.1 to -2.7), respectively, indicating bone loss. Serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa were significantly higher than those of controls. The 17% of restricting type and 40% of binge eating/purging type anorexia nervosa patients, serum levels of undercarboxylated osteocalcin were higher than 4.5 ng/ml and were diagnosed with vitamin K deficiency. Serum levels of undercarboxylated osteocalcin correlated significantly and negatively with vitamin K intake in patients with anorexia nervosa. CONCLUSIONS: Patients with anorexia nervosa had vitamin K deficiency. Since a supplement of vitamin K might be effective for maintaining bone quality, we provide recommendations regarding vitamin K intake for prevention and treatment of osteoporosis in patients with AN. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/24909585/Vitamin_K_deficiency_evaluated_by_serum_levels_of_undercarboxylated_osteocalcin_in_patients_with_anorexia_nervosa_with_bone_loss_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(14)00124-1 DB - PRIME DP - Unbound Medicine ER -