Tags

Type your tag names separated by a space and hit enter

Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss.
Clin Nutr 2015; 34(3):443-8CN

Abstract

BACKGROUND & AIMS

Osteoporosis is a chief complication in patients with anorexia nervosa. Serum levels of undercarboxylated osteocalcin reflect serum and bone vitamin K deficiency. We investigated vitamin K status in patients with anorexia nervosa to help establish prevention and treatment recommendations for osteoporosis.

METHODS

Fifty-four female amenorrheic patients with anorexia nervosa (29 restricting-type and 25 binge eating/purging type) (age, 28.0 (26.7-31.1) (mean (95% CI)) years; body mass index, 14.8 (14.1-15.5) kg/m(2), duration of illness; 107.3 (88.5-126.0) months) and 15 age-matched healthy females were included in this study. We measured serum levels of undercarboxylated osteocalcin, biochemical and nutritional markers, and bone metabolic markers. Dietary vitamin K intake was evaluated by a questionnaire.

RESULTS

Lumbar bone mineral density and T-scores in patients with anorexia nervosa were 0.756 (0.721-0.790) g/cm(2) and -2.4 (-2.1 to -2.7), respectively, indicating bone loss. Serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa were significantly higher than those of controls. The 17% of restricting type and 40% of binge eating/purging type anorexia nervosa patients, serum levels of undercarboxylated osteocalcin were higher than 4.5 ng/ml and were diagnosed with vitamin K deficiency. Serum levels of undercarboxylated osteocalcin correlated significantly and negatively with vitamin K intake in patients with anorexia nervosa.

CONCLUSIONS

Patients with anorexia nervosa had vitamin K deficiency. Since a supplement of vitamin K might be effective for maintaining bone quality, we provide recommendations regarding vitamin K intake for prevention and treatment of osteoporosis in patients with AN.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Saitama Sekishinkai Hospital, Saitama, Japan.Health Service Center, National Graduate Institute For Policy Studies, Tokyo, Japan; Institute of Women's Health, Tokyo Women's Medical University, Tokyo, Japan. Electronic address: marihs@grips.ac.jp.Division of Endocrinology and Metabolism, Saitama Sekishinkai Hospital, Saitama, Japan.Department of Internal Medicine, Nagai Hitachinomori Hospital, Ibaraki, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24909585

Citation

Urano, Ayako, et al. "Vitamin K Deficiency Evaluated By Serum Levels of Undercarboxylated Osteocalcin in Patients With Anorexia Nervosa With Bone Loss." Clinical Nutrition (Edinburgh, Scotland), vol. 34, no. 3, 2015, pp. 443-8.
Urano A, Hotta M, Ohwada R, et al. Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss. Clin Nutr. 2015;34(3):443-8.
Urano, A., Hotta, M., Ohwada, R., & Araki, M. (2015). Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss. Clinical Nutrition (Edinburgh, Scotland), 34(3), pp. 443-8. doi:10.1016/j.clnu.2014.04.016.
Urano A, et al. Vitamin K Deficiency Evaluated By Serum Levels of Undercarboxylated Osteocalcin in Patients With Anorexia Nervosa With Bone Loss. Clin Nutr. 2015;34(3):443-8. PubMed PMID: 24909585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss. AU - Urano,Ayako, AU - Hotta,Mari, AU - Ohwada,Rina, AU - Araki,Mariko, Y1 - 2014/05/28/ PY - 2013/08/26/received PY - 2014/04/10/revised PY - 2014/04/23/accepted PY - 2014/6/10/entrez PY - 2014/6/10/pubmed PY - 2016/2/24/medline KW - Anorexia nervosa KW - Osteoporosis KW - Undercarboxylated osteocalcin KW - Vitamin K SP - 443 EP - 8 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 34 IS - 3 N2 - BACKGROUND & AIMS: Osteoporosis is a chief complication in patients with anorexia nervosa. Serum levels of undercarboxylated osteocalcin reflect serum and bone vitamin K deficiency. We investigated vitamin K status in patients with anorexia nervosa to help establish prevention and treatment recommendations for osteoporosis. METHODS: Fifty-four female amenorrheic patients with anorexia nervosa (29 restricting-type and 25 binge eating/purging type) (age, 28.0 (26.7-31.1) (mean (95% CI)) years; body mass index, 14.8 (14.1-15.5) kg/m(2), duration of illness; 107.3 (88.5-126.0) months) and 15 age-matched healthy females were included in this study. We measured serum levels of undercarboxylated osteocalcin, biochemical and nutritional markers, and bone metabolic markers. Dietary vitamin K intake was evaluated by a questionnaire. RESULTS: Lumbar bone mineral density and T-scores in patients with anorexia nervosa were 0.756 (0.721-0.790) g/cm(2) and -2.4 (-2.1 to -2.7), respectively, indicating bone loss. Serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa were significantly higher than those of controls. The 17% of restricting type and 40% of binge eating/purging type anorexia nervosa patients, serum levels of undercarboxylated osteocalcin were higher than 4.5 ng/ml and were diagnosed with vitamin K deficiency. Serum levels of undercarboxylated osteocalcin correlated significantly and negatively with vitamin K intake in patients with anorexia nervosa. CONCLUSIONS: Patients with anorexia nervosa had vitamin K deficiency. Since a supplement of vitamin K might be effective for maintaining bone quality, we provide recommendations regarding vitamin K intake for prevention and treatment of osteoporosis in patients with AN. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/24909585/Vitamin_K_deficiency_evaluated_by_serum_levels_of_undercarboxylated_osteocalcin_in_patients_with_anorexia_nervosa_with_bone_loss_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(14)00124-1 DB - PRIME DP - Unbound Medicine ER -