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Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa.
J Eur Acad Dermatol Venereol 2015; 29(2):371-6JE

Abstract

BACKGROUND

Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease affecting skin that bears apocrine glands. Only anecdotal reports and a few small studies have demonstrated a possible association between HS and depression, but these studies were uncontrolled or were based on small sample sizes. To the best of our knowledge, the association between HS and other psychiatric disorders has never been investigated.

OBJECTIVES

To investigate the association between HS and psychiatric disorders: depression, anxiety, psychoses, schizophrenia and bipolar disorder.

METHODS

A cross-sectional study was conducted utilizing the database of Clalit Health Services (over 4,100,000 patients). Case patients were defined as having HS when diagnosed by a dermatologist. Control patients without HS were age and gender matched in a 2 : 1 manner. The proportions of patients with psychiatric diseases were compared between patients with and without HS. The association between HS and psychiatric diseases was assessed in multivariate models using logistic regression analyses.

RESULTS

The study included 3207 patients with HS and 6412 age- and gender-matched controls. Depression was diagnosed in 5.9% of patients with HS vs. 3.5% of patients without HS (P < 0.001). Anxiety was diagnosed in 3.9% of patients with HS vs. 2.4% of patients without HS (P < 0.001). These associations were significant after controlling for the confounders age and gender (Depression: OR = 1.7, 95% CI: 1.4-2.1; Anxiety: OR = 1.7, 95% CI: 1.3-2.1).

CONCLUSIONS

Hidradenitis suppurativa was associated with depression and anxiety. Dermatologists treating patients with HS should be aware of this important association.

Authors+Show Affiliations

Department of Dermatology and Venereology, Soroka University Medical Center, Beer-Sheva, Israel; Faculty of Health Sciences, Division of Medicine, Ben-Gurion University of the Negev, Beer-Sheva, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24909646

Citation

Shavit, E, et al. "Psychiatric Comorbidities in 3207 Patients With Hidradenitis Suppurativa." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 29, no. 2, 2015, pp. 371-6.
Shavit E, Dreiher J, Freud T, et al. Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa. J Eur Acad Dermatol Venereol. 2015;29(2):371-6.
Shavit, E., Dreiher, J., Freud, T., Halevy, S., Vinker, S., & Cohen, A. D. (2015). Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa. Journal of the European Academy of Dermatology and Venereology : JEADV, 29(2), pp. 371-6. doi:10.1111/jdv.12567.
Shavit E, et al. Psychiatric Comorbidities in 3207 Patients With Hidradenitis Suppurativa. J Eur Acad Dermatol Venereol. 2015;29(2):371-6. PubMed PMID: 24909646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa. AU - Shavit,E, AU - Dreiher,J, AU - Freud,T, AU - Halevy,S, AU - Vinker,S, AU - Cohen,A D, Y1 - 2014/06/09/ PY - 2013/12/04/received PY - 2014/04/29/accepted PY - 2014/6/10/entrez PY - 2014/6/10/pubmed PY - 2015/10/16/medline SP - 371 EP - 6 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 29 IS - 2 N2 - BACKGROUND: Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease affecting skin that bears apocrine glands. Only anecdotal reports and a few small studies have demonstrated a possible association between HS and depression, but these studies were uncontrolled or were based on small sample sizes. To the best of our knowledge, the association between HS and other psychiatric disorders has never been investigated. OBJECTIVES: To investigate the association between HS and psychiatric disorders: depression, anxiety, psychoses, schizophrenia and bipolar disorder. METHODS: A cross-sectional study was conducted utilizing the database of Clalit Health Services (over 4,100,000 patients). Case patients were defined as having HS when diagnosed by a dermatologist. Control patients without HS were age and gender matched in a 2 : 1 manner. The proportions of patients with psychiatric diseases were compared between patients with and without HS. The association between HS and psychiatric diseases was assessed in multivariate models using logistic regression analyses. RESULTS: The study included 3207 patients with HS and 6412 age- and gender-matched controls. Depression was diagnosed in 5.9% of patients with HS vs. 3.5% of patients without HS (P < 0.001). Anxiety was diagnosed in 3.9% of patients with HS vs. 2.4% of patients without HS (P < 0.001). These associations were significant after controlling for the confounders age and gender (Depression: OR = 1.7, 95% CI: 1.4-2.1; Anxiety: OR = 1.7, 95% CI: 1.3-2.1). CONCLUSIONS: Hidradenitis suppurativa was associated with depression and anxiety. Dermatologists treating patients with HS should be aware of this important association. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/24909646/Psychiatric_comorbidities_in_3207_patients_with_hidradenitis_suppurativa_ L2 - https://doi.org/10.1111/jdv.12567 DB - PRIME DP - Unbound Medicine ER -