Tags

Type your tag names separated by a space and hit enter

DNA photoprotection conveyed by sunscreen.
J Cosmet Dermatol. 2014 Jun; 13(2):99-102.JC

Abstract

INTRODUCTION

Skin photoaging is the consequence of solar UV exposure, and DNA damage is an important part of this process. The objective of the current work was to demonstrate that in vitro skin models can be utilized to confirm that DNA damage protection is provided by sunscreens.

METHODS

Skin equivalents were exposed to full-spectrum UV light administered with a standard research solar simulator with and without pre-application of sunscreen. Cyclopyrimidine dimer (CPD) and sunburn cell (SBC) formation as well as CPD quantitation were evaluated to determine DNA damage protection provided by the sunscreen.

RESULTS

Marked decreases in both CPDs and SBCs were observed when sunscreen was applied prior to UV exposure.

CONCLUSIONS

Sunscreen application prior to full-spectrum solar UV exposure protects DNA from photodamage measured by CPD and SBC formation. This can be expected to lessen the risk of photoaging and malignant transformation.

Authors+Show Affiliations

Innovative Skincare, Burbank, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24910272

Citation

DeHaven, Charlene, et al. "DNA Photoprotection Conveyed By Sunscreen." Journal of Cosmetic Dermatology, vol. 13, no. 2, 2014, pp. 99-102.
DeHaven C, Hayden PJ, Armento A, et al. DNA photoprotection conveyed by sunscreen. J Cosmet Dermatol. 2014;13(2):99-102.
DeHaven, C., Hayden, P. J., Armento, A., & Oldach, J. (2014). DNA photoprotection conveyed by sunscreen. Journal of Cosmetic Dermatology, 13(2), 99-102. https://doi.org/10.1111/jocd.12087
DeHaven C, et al. DNA Photoprotection Conveyed By Sunscreen. J Cosmet Dermatol. 2014;13(2):99-102. PubMed PMID: 24910272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DNA photoprotection conveyed by sunscreen. AU - DeHaven,Charlene, AU - Hayden,Patrick J, AU - Armento,Alexander, AU - Oldach,Jonathan, PY - 2014/03/07/accepted PY - 2014/6/10/entrez PY - 2014/6/10/pubmed PY - 2015/2/24/medline KW - DNA damage KW - apoptosis KW - cyclopyrimidine dimer KW - photoaging KW - sunburn cell KW - sunscreens SP - 99 EP - 102 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 13 IS - 2 N2 - INTRODUCTION: Skin photoaging is the consequence of solar UV exposure, and DNA damage is an important part of this process. The objective of the current work was to demonstrate that in vitro skin models can be utilized to confirm that DNA damage protection is provided by sunscreens. METHODS: Skin equivalents were exposed to full-spectrum UV light administered with a standard research solar simulator with and without pre-application of sunscreen. Cyclopyrimidine dimer (CPD) and sunburn cell (SBC) formation as well as CPD quantitation were evaluated to determine DNA damage protection provided by the sunscreen. RESULTS: Marked decreases in both CPDs and SBCs were observed when sunscreen was applied prior to UV exposure. CONCLUSIONS: Sunscreen application prior to full-spectrum solar UV exposure protects DNA from photodamage measured by CPD and SBC formation. This can be expected to lessen the risk of photoaging and malignant transformation. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/24910272/DNA_photoprotection_conveyed_by_sunscreen_ L2 - https://doi.org/10.1111/jocd.12087 DB - PRIME DP - Unbound Medicine ER -