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Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial.
J Dent (Tehran). 2014 Mar; 11(2):167-71.JD

Abstract

OBJECTIVE

Recurrent aphthous stomatitis (RAS) is the most common and painful oral inflammatory lesion with an unknown etiology. This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.

MATERIALS AND METHODS

Thirty-one patients with RAS participated in this double-blind clinical trial. Subjects were randomly divided into two groups. The control group (n=14) received drug mixture as drug A (diphenhydramine and AlMgS) and the case group (n=17) received drug B (ibuprofen, diphenhydramine and AlMgS). Drugs were topically applied on ulcers by the patients three times a day for 3 days. Patients were re-examined for the symptoms on the fourth day following their first visits using VAS (Visual Analogue Scale) tool. Statistical analysis was performed using paired t-test, independent t-test and chi-square test.

RESULTS

The mean of pain reduction was 3.17±2 (P<0.001) and 3.82±1.79 (P<0.001) in the case and control group, respectively. The difference in pain reduction between both groups was not statistically significant. In addition, no significant difference was detected between the two groups regarding the duration of pain or burning sensation (P=0.57).

CONCLUSION

The results of this study demonstrate that in comparison with diphenhydramine and AlMgS syrup, the studied mixture did not effectively reduce the level of pain, duration and burning sensation.

Authors+Show Affiliations

Associate Professor, Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.Assistant Professor, Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.Associate Professor of Pharmacology, Department of Pharmacology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.Dentist, Research Center, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.Associate Professor of Biostatistics, Department of Biostatistics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24910692

Citation

Borhan-Mojabi, Katayoun, et al. "Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" On Recurrent Aphthous Stomatitis: a Randomized Controlled Trial." Journal of Dentistry (Tehran, Iran), vol. 11, no. 2, 2014, pp. 167-71.
Borhan-Mojabi K, Mirmiran F, Nassiri-Asl M, et al. Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial. J Dent (Tehran). 2014;11(2):167-71.
Borhan-Mojabi, K., Mirmiran, F., Nassiri-Asl, M., Nazeman, P., & Jahanihashemi, H. (2014). Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial. Journal of Dentistry (Tehran, Iran), 11(2), 167-71.
Borhan-Mojabi K, et al. Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" On Recurrent Aphthous Stomatitis: a Randomized Controlled Trial. J Dent (Tehran). 2014;11(2):167-71. PubMed PMID: 24910692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis: A Randomized Controlled Trial. AU - Borhan-Mojabi,Katayoun, AU - Mirmiran,Faezeh, AU - Nassiri-Asl,Marjan, AU - Nazeman,Pantea, AU - Jahanihashemi,Hassan, Y1 - 2014/03/31/ PY - 2013/07/25/received PY - 2013/12/07/accepted PY - 2014/6/10/entrez PY - 2014/6/10/pubmed PY - 2014/6/10/medline KW - Ibuprofen KW - Stomatitis, Aphthous KW - Treatment Efficacy SP - 167 EP - 71 JF - Journal of dentistry (Tehran, Iran) JO - J Dent (Tehran) VL - 11 IS - 2 N2 - OBJECTIVE: Recurrent aphthous stomatitis (RAS) is the most common and painful oral inflammatory lesion with an unknown etiology. This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain. MATERIALS AND METHODS: Thirty-one patients with RAS participated in this double-blind clinical trial. Subjects were randomly divided into two groups. The control group (n=14) received drug mixture as drug A (diphenhydramine and AlMgS) and the case group (n=17) received drug B (ibuprofen, diphenhydramine and AlMgS). Drugs were topically applied on ulcers by the patients three times a day for 3 days. Patients were re-examined for the symptoms on the fourth day following their first visits using VAS (Visual Analogue Scale) tool. Statistical analysis was performed using paired t-test, independent t-test and chi-square test. RESULTS: The mean of pain reduction was 3.17±2 (P<0.001) and 3.82±1.79 (P<0.001) in the case and control group, respectively. The difference in pain reduction between both groups was not statistically significant. In addition, no significant difference was detected between the two groups regarding the duration of pain or burning sensation (P=0.57). CONCLUSION: The results of this study demonstrate that in comparison with diphenhydramine and AlMgS syrup, the studied mixture did not effectively reduce the level of pain, duration and burning sensation. SN - 1735-2150 UR - https://www.unboundmedicine.com/medline/citation/24910692/Therapeutic_Effects_of_"Ibuprofen_Diphenhydramine_and_Aluminium_MgS"_on_Recurrent_Aphthous_Stomatitis:_A_Randomized_Controlled_Trial_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24910692/ DB - PRIME DP - Unbound Medicine ER -
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