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Amino acid-dependent transformations of citrate-coated silver nanoparticles: impact on morphology, stability and toxicity.
Toxicol Lett. 2014 Aug 17; 229(1):17-24.TL

Abstract

Humans face the risk of exposure to silver nanoparticles (AgNPs) due to their extensive application in consumer products. AgNPs can interact with many substances in the human body due to their chemically unstable nature and high activity properties, which might result in unknown hazards and even some serious diseases for humans. As the basic constituent element of human bodies, amino acids (AAs) differ in concentration and variety in different cells and tissues. Thus, understanding the transformation of citrate-coated AgNPs in the presence of AAs is crucial for determining their fate and toxicity in the human body. Our study focused on the transformation of the morphology, dissolution behavior and reaction product of AgNPs in different AA-containing systems and then evaluated the effect of these transformations on the cytotoxicity of AgNPs. The obtained results indicated that the addition of glycine with the lowest Ag(+) binding energy had little effect on the transformations and toxicity of AgNPs. While in the presence of histidine with higher Ag(+) binding energy, the Ag(+) release and particle size of AgNPs obviously increased. These transformations resulted in a decrease in the cytotoxicity of AgNPs due to the formation of Ag-His complex and the growth of AgNPs. Furthermore, l-cysteine with the highest Ag(+) binding energy could easily interact with AgNPs, transforming them completely to form [Ag(Cys)n](+) and Ag2S precipitates, which induced the largest decrease in AgNP toxicity. In summary, our results may provide useful information to understand the fate, transformation, and toxicity of citrate-coated AgNPs in the human body.

Authors+Show Affiliations

Institute of Urban Environment, Chinese Academy of Sciences, Jimei Road 1799, Xiamen 361021, China.Institute of Urban Environment, Chinese Academy of Sciences, Jimei Road 1799, Xiamen 361021, China.Institute of Urban Environment, Chinese Academy of Sciences, Jimei Road 1799, Xiamen 361021, China.Institute of Urban Environment, Chinese Academy of Sciences, Jimei Road 1799, Xiamen 361021, China. Electronic address: hwzhang@iue.ac.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24910988

Citation

Shi, Junpeng, et al. "Amino Acid-dependent Transformations of Citrate-coated Silver Nanoparticles: Impact On Morphology, Stability and Toxicity." Toxicology Letters, vol. 229, no. 1, 2014, pp. 17-24.
Shi J, Sun X, Zou X, et al. Amino acid-dependent transformations of citrate-coated silver nanoparticles: impact on morphology, stability and toxicity. Toxicol Lett. 2014;229(1):17-24.
Shi, J., Sun, X., Zou, X., & Zhang, H. (2014). Amino acid-dependent transformations of citrate-coated silver nanoparticles: impact on morphology, stability and toxicity. Toxicology Letters, 229(1), 17-24. https://doi.org/10.1016/j.toxlet.2014.06.014
Shi J, et al. Amino Acid-dependent Transformations of Citrate-coated Silver Nanoparticles: Impact On Morphology, Stability and Toxicity. Toxicol Lett. 2014 Aug 17;229(1):17-24. PubMed PMID: 24910988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amino acid-dependent transformations of citrate-coated silver nanoparticles: impact on morphology, stability and toxicity. AU - Shi,Junpeng, AU - Sun,Xia, AU - Zou,Xiaoyan, AU - Zhang,Hongwu, Y1 - 2014/06/06/ PY - 2014/05/03/received PY - 2014/06/04/revised PY - 2014/06/05/accepted PY - 2014/6/10/entrez PY - 2014/6/10/pubmed PY - 2014/9/10/medline KW - Amino acid KW - Silver nanoparticles KW - Toxicity KW - Transformtion SP - 17 EP - 24 JF - Toxicology letters JO - Toxicol Lett VL - 229 IS - 1 N2 - Humans face the risk of exposure to silver nanoparticles (AgNPs) due to their extensive application in consumer products. AgNPs can interact with many substances in the human body due to their chemically unstable nature and high activity properties, which might result in unknown hazards and even some serious diseases for humans. As the basic constituent element of human bodies, amino acids (AAs) differ in concentration and variety in different cells and tissues. Thus, understanding the transformation of citrate-coated AgNPs in the presence of AAs is crucial for determining their fate and toxicity in the human body. Our study focused on the transformation of the morphology, dissolution behavior and reaction product of AgNPs in different AA-containing systems and then evaluated the effect of these transformations on the cytotoxicity of AgNPs. The obtained results indicated that the addition of glycine with the lowest Ag(+) binding energy had little effect on the transformations and toxicity of AgNPs. While in the presence of histidine with higher Ag(+) binding energy, the Ag(+) release and particle size of AgNPs obviously increased. These transformations resulted in a decrease in the cytotoxicity of AgNPs due to the formation of Ag-His complex and the growth of AgNPs. Furthermore, l-cysteine with the highest Ag(+) binding energy could easily interact with AgNPs, transforming them completely to form [Ag(Cys)n](+) and Ag2S precipitates, which induced the largest decrease in AgNP toxicity. In summary, our results may provide useful information to understand the fate, transformation, and toxicity of citrate-coated AgNPs in the human body. SN - 1879-3169 UR - https://www.unboundmedicine.com/medline/citation/24910988/Amino_acid_dependent_transformations_of_citrate_coated_silver_nanoparticles:_impact_on_morphology_stability_and_toxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4274(14)00252-5 DB - PRIME DP - Unbound Medicine ER -