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Symplocos cochinchinensis attenuates streptozotocin-diabetes induced pathophysiological alterations of liver, kidney, pancreas and eye lens in rats.
Exp Toxicol Pathol. 2014 Sep; 66(7):281-91.ET

Abstract

The beneficial effects of hydroethanol extract of Symplocos cochinchinensis (SCE) has been explored against hyperglycemia associated secondary complications in streptozotocin induced diabetic rat model. The experimental groups consist of normal control (NC), diabetic control (DC), DC + metformin 100 mg kg(-1) bwd, DC + SCE 250 and DC + SCE 500. SCEs and metformin were administered daily for 21 days and sacrificed on day 22. Oral glucose tolerance test, plasma insulin, % HbA1c, urea, creatinine, aspartate aminotransferase, alanine aminotransferase, albumin, total protein etc. were analysed. Aldose reductase (AR) activity in the eye lens was also checked. On day 21, DC rats showed significantly abnormal glucose response, HOMA-IR, % HbA1c, decreased activity of antioxidant enzymes and GSH, elevated AR activity, hepatic and renal oxidative stress markers like malondialdehyde, protein carbonyls compared to NC. DC rats also exhibited increased level of plasma urea and creatinine. Treatment with SCE protected from the deleterious alterations of biochemical parameters in a dose dependent manner including histopathological alterations in pancreas. SCE 500 exhibited 46.28% of glucose lowering effect and decreased HOMA-IR (2.47), % HbA1c (6.61), lens AR activity (15.99%), and hepatic, renal oxidative stress and function markers compared to DC group. Considerable amount of liver and muscle glycogen was replenished by SCE treatment in diabetic animals. Although metformin showed better effect, the activity of SCE was very much comparable with this drug.

Authors+Show Affiliations

Agroprocessing and Natural Products Division, Council of Scientific and Industrial Research - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram 695019, Kerala, India.Agroprocessing and Natural Products Division, Council of Scientific and Industrial Research - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram 695019, Kerala, India.Division of Biochemistry, CSIR - Central Drug Research Institute (CSIR-CDRI), Lucknow 226001, Uttar Pradesh, India.Division of Toxicology, CSIR-CDRI, Lucknow 226001, Uttar Pradesh, India.Division of Biochemistry, CSIR - Central Drug Research Institute (CSIR-CDRI), Lucknow 226001, Uttar Pradesh, India.Agroprocessing and Natural Products Division, Council of Scientific and Industrial Research - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram 695019, Kerala, India. Electronic address: raghukgopal2009@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24912748

Citation

Antu, Kalathookunnel Antony, et al. "Symplocos Cochinchinensis Attenuates Streptozotocin-diabetes Induced Pathophysiological Alterations of Liver, Kidney, Pancreas and Eye Lens in Rats." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 66, no. 7, 2014, pp. 281-91.
Antu KA, Riya MP, Mishra A, et al. Symplocos cochinchinensis attenuates streptozotocin-diabetes induced pathophysiological alterations of liver, kidney, pancreas and eye lens in rats. Exp Toxicol Pathol. 2014;66(7):281-91.
Antu, K. A., Riya, M. P., Mishra, A., Sharma, S., Srivastava, A. K., & Raghu, K. G. (2014). Symplocos cochinchinensis attenuates streptozotocin-diabetes induced pathophysiological alterations of liver, kidney, pancreas and eye lens in rats. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 66(7), 281-91. https://doi.org/10.1016/j.etp.2014.05.004
Antu KA, et al. Symplocos Cochinchinensis Attenuates Streptozotocin-diabetes Induced Pathophysiological Alterations of Liver, Kidney, Pancreas and Eye Lens in Rats. Exp Toxicol Pathol. 2014;66(7):281-91. PubMed PMID: 24912748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Symplocos cochinchinensis attenuates streptozotocin-diabetes induced pathophysiological alterations of liver, kidney, pancreas and eye lens in rats. AU - Antu,Kalathookunnel Antony, AU - Riya,Mariam Philip, AU - Mishra,Arvind, AU - Sharma,Sharad, AU - Srivastava,Arvind K, AU - Raghu,Kozhiparambil Gopalan, Y1 - 2014/06/06/ PY - 2014/01/26/received PY - 2014/04/11/revised PY - 2014/05/14/accepted PY - 2014/6/11/entrez PY - 2014/6/11/pubmed PY - 2015/1/31/medline KW - % HbA1c KW - Aldose reductase KW - Aspartate aminotransferase KW - Carbonyl content KW - Creatinine KW - Diabetes KW - Insulin KW - Pancreas KW - Streptozotocin KW - Symplocos cochinchinensis SP - 281 EP - 91 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp Toxicol Pathol VL - 66 IS - 7 N2 - The beneficial effects of hydroethanol extract of Symplocos cochinchinensis (SCE) has been explored against hyperglycemia associated secondary complications in streptozotocin induced diabetic rat model. The experimental groups consist of normal control (NC), diabetic control (DC), DC + metformin 100 mg kg(-1) bwd, DC + SCE 250 and DC + SCE 500. SCEs and metformin were administered daily for 21 days and sacrificed on day 22. Oral glucose tolerance test, plasma insulin, % HbA1c, urea, creatinine, aspartate aminotransferase, alanine aminotransferase, albumin, total protein etc. were analysed. Aldose reductase (AR) activity in the eye lens was also checked. On day 21, DC rats showed significantly abnormal glucose response, HOMA-IR, % HbA1c, decreased activity of antioxidant enzymes and GSH, elevated AR activity, hepatic and renal oxidative stress markers like malondialdehyde, protein carbonyls compared to NC. DC rats also exhibited increased level of plasma urea and creatinine. Treatment with SCE protected from the deleterious alterations of biochemical parameters in a dose dependent manner including histopathological alterations in pancreas. SCE 500 exhibited 46.28% of glucose lowering effect and decreased HOMA-IR (2.47), % HbA1c (6.61), lens AR activity (15.99%), and hepatic, renal oxidative stress and function markers compared to DC group. Considerable amount of liver and muscle glycogen was replenished by SCE treatment in diabetic animals. Although metformin showed better effect, the activity of SCE was very much comparable with this drug. SN - 1618-1433 UR - https://www.unboundmedicine.com/medline/citation/24912748/Symplocos_cochinchinensis_attenuates_streptozotocin_diabetes_induced_pathophysiological_alterations_of_liver_kidney_pancreas_and_eye_lens_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0940-2993(14)00070-0 DB - PRIME DP - Unbound Medicine ER -