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Saturated and trans fats and dementia: a systematic review.

Abstract

Cognitive disorders of later life are potentially devastating. To estimate the relationship between saturated and trans fat intake and risk of cognitive disorders. PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for studies reporting saturated or trans fat intake and incident dementia, Alzheimer's disease (AD), or mild cognitive impairment (MCI) or cognitive decline. Only observational studies met the inclusion criteria: 4 for AD or other dementias, 4 for MCI, and 4 for cognitive decline. Saturated fat intake was positively associated with AD risk in 3 of 4 studies, whereas the fourth suggested an inverse relationship. Saturated fat intake was also positively associated with total dementia in 1 of 2 studies, with MCI in 1 of 4 studies, and with cognitive decline in 2 of 4 studies. Relationships between trans fat intake and dementia were examined in 3 reports with mixed results. Several, although not all, prospective studies indicate relationships between saturated and trans fat intake and risk of cognitive disorders.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, The George Washington University School of Medicine, Washington, DC, USA; Physicians Committee for Responsible Medicine, Washington, DC, USA. Electronic address: nbarnard@pcrm.org.

    ,

    Physicians Committee for Responsible Medicine, Washington, DC, USA.

    Physicians Committee for Responsible Medicine, Washington, DC, USA.

    Source

    Neurobiology of aging 35 Suppl 2: 2014 Sep pg S65-73

    MeSH

    Alzheimer Disease
    Cognitive Dysfunction
    Databases, Bibliographic
    Dementia
    Dietary Fats
    Fatty Acids
    Humans
    Incidence
    Risk
    Trans Fatty Acids

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Systematic Review

    Language

    eng

    PubMed ID

    24916582

    Citation

    Barnard, Neal D., et al. "Saturated and Trans Fats and Dementia: a Systematic Review." Neurobiology of Aging, vol. 35 Suppl 2, 2014, pp. S65-73.
    Barnard ND, Bunner AE, Agarwal U. Saturated and trans fats and dementia: a systematic review. Neurobiol Aging. 2014;35 Suppl 2:S65-73.
    Barnard, N. D., Bunner, A. E., & Agarwal, U. (2014). Saturated and trans fats and dementia: a systematic review. Neurobiology of Aging, 35 Suppl 2, pp. S65-73. doi:10.1016/j.neurobiolaging.2014.02.030.
    Barnard ND, Bunner AE, Agarwal U. Saturated and Trans Fats and Dementia: a Systematic Review. Neurobiol Aging. 2014;35 Suppl 2:S65-73. PubMed PMID: 24916582.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Saturated and trans fats and dementia: a systematic review. AU - Barnard,Neal D, AU - Bunner,Anne E, AU - Agarwal,Ulka, Y1 - 2014/05/15/ PY - 2013/10/24/received PY - 2014/02/27/accepted PY - 2014/6/12/entrez PY - 2014/6/12/pubmed PY - 2015/1/21/medline KW - Alzheimer's disease KW - Dementia KW - Fatty acids KW - Nutrition KW - Saturated fat KW - Trans fatty acids SP - S65 EP - 73 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 35 Suppl 2 N2 - Cognitive disorders of later life are potentially devastating. To estimate the relationship between saturated and trans fat intake and risk of cognitive disorders. PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for studies reporting saturated or trans fat intake and incident dementia, Alzheimer's disease (AD), or mild cognitive impairment (MCI) or cognitive decline. Only observational studies met the inclusion criteria: 4 for AD or other dementias, 4 for MCI, and 4 for cognitive decline. Saturated fat intake was positively associated with AD risk in 3 of 4 studies, whereas the fourth suggested an inverse relationship. Saturated fat intake was also positively associated with total dementia in 1 of 2 studies, with MCI in 1 of 4 studies, and with cognitive decline in 2 of 4 studies. Relationships between trans fat intake and dementia were examined in 3 reports with mixed results. Several, although not all, prospective studies indicate relationships between saturated and trans fat intake and risk of cognitive disorders. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/24916582/Saturated_and_trans_fats_and_dementia:_a_systematic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(14)00355-8 DB - PRIME DP - Unbound Medicine ER -