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Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study.
J Am Geriatr Soc. 2014 Jul; 62(7):1224-30.JA

Abstract

OBJECTIVES

To determine the effect of milk and dairy intake on the development of all-cause dementia and its subtypes in an elderly Japanese population.

DESIGN

Prospective cohort study.

SETTING

The Hisayama Study, Japan.

PARTICIPANTS

Individuals aged 60 and older without dementia (N = 1,081).

MEASUREMENTS

Milk and dairy intake was estimated using a 70-item semiquantitative food frequency questionnaire grouped into quartiles. The risk estimates of milk and dairy intake on the development of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were computed using a Cox proportional hazards model.

RESULTS

Over 17 years of follow-up, 303 subjects developed all-cause dementia; 166 had AD, and 98 had VaD. The age- and sex-adjusted incidence of all-cause dementia, AD, and VaD significantly decreased as milk and dairy intake level increased (P for trend = .03 for all-cause dementia, .04 for AD, .01 for VaD). After adjusting for potential confounders, the linear relationship between milk and dairy intake and development of AD remained significant (P for trend = .03), whereas the relationships with all-cause dementia and VaD were not significant. The risk of AD was significantly lower in the second, third, and fourth quartiles of milk and dairy intake than in the first quartile.

CONCLUSION

Greater milk and dairy intake reduced the risk of dementia, especially AD, in the general Japanese population.

Authors+Show Affiliations

Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24916840

Citation

Ozawa, Mio, et al. "Milk and Dairy Consumption and Risk of Dementia in an Elderly Japanese Population: the Hisayama Study." Journal of the American Geriatrics Society, vol. 62, no. 7, 2014, pp. 1224-30.
Ozawa M, Ohara T, Ninomiya T, et al. Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study. J Am Geriatr Soc. 2014;62(7):1224-30.
Ozawa, M., Ohara, T., Ninomiya, T., Hata, J., Yoshida, D., Mukai, N., Nagata, M., Uchida, K., Shirota, T., Kitazono, T., & Kiyohara, Y. (2014). Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study. Journal of the American Geriatrics Society, 62(7), 1224-30. https://doi.org/10.1111/jgs.12887
Ozawa M, et al. Milk and Dairy Consumption and Risk of Dementia in an Elderly Japanese Population: the Hisayama Study. J Am Geriatr Soc. 2014;62(7):1224-30. PubMed PMID: 24916840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study. AU - Ozawa,Mio, AU - Ohara,Tomoyuki, AU - Ninomiya,Toshiharu, AU - Hata,Jun, AU - Yoshida,Daigo, AU - Mukai,Naoko, AU - Nagata,Masaharu, AU - Uchida,Kazuhiro, AU - Shirota,Tomoko, AU - Kitazono,Takanari, AU - Kiyohara,Yutaka, Y1 - 2014/06/10/ PY - 2014/6/12/entrez PY - 2014/6/12/pubmed PY - 2014/9/16/medline KW - Alzheimer's disease KW - dementia KW - milk and dairy KW - vascular dementia SP - 1224 EP - 30 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 62 IS - 7 N2 - OBJECTIVES: To determine the effect of milk and dairy intake on the development of all-cause dementia and its subtypes in an elderly Japanese population. DESIGN: Prospective cohort study. SETTING: The Hisayama Study, Japan. PARTICIPANTS: Individuals aged 60 and older without dementia (N = 1,081). MEASUREMENTS: Milk and dairy intake was estimated using a 70-item semiquantitative food frequency questionnaire grouped into quartiles. The risk estimates of milk and dairy intake on the development of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were computed using a Cox proportional hazards model. RESULTS: Over 17 years of follow-up, 303 subjects developed all-cause dementia; 166 had AD, and 98 had VaD. The age- and sex-adjusted incidence of all-cause dementia, AD, and VaD significantly decreased as milk and dairy intake level increased (P for trend = .03 for all-cause dementia, .04 for AD, .01 for VaD). After adjusting for potential confounders, the linear relationship between milk and dairy intake and development of AD remained significant (P for trend = .03), whereas the relationships with all-cause dementia and VaD were not significant. The risk of AD was significantly lower in the second, third, and fourth quartiles of milk and dairy intake than in the first quartile. CONCLUSION: Greater milk and dairy intake reduced the risk of dementia, especially AD, in the general Japanese population. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/24916840/Milk_and_dairy_consumption_and_risk_of_dementia_in_an_elderly_Japanese_population:_the_Hisayama_Study_ L2 - https://doi.org/10.1111/jgs.12887 DB - PRIME DP - Unbound Medicine ER -