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Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression.
Drug Dev Ind Pharm. 2015 Jun; 41(6):1037-46.DD

Abstract

The objectives of this study were to investigate the effect of storage temperature on drug release from matrices containing 10, 40 and 70% w/w ibuprofen in Kollidon® SR (KSR). The matrix tablets were produced by direct compression and then kept at 30 and 45 °C for 3 months. Drug release from the matrix tablets was examined after storage for 0, 1, 4 and 12 weeks. Scanning electron microscope was used to reveal physical appearance of the tablet surface at the respective time intervals. In addition, differential scanning calorimeter was used to investigate glass transition temperature (Tg) of ibuprofen in KSR at 0-100% w/w based on the principle of Gordon-Taylor equation. At 45 °C, the dissolution of ibuprofen in KSR as well as the coalescence of polymer particles were observed to be higher than those of storage at 30 °C. The physical state of ibuprofen dispersed in the polymeric matrix and degree of polymer coalescence led to the variation of drug release. The coalescence of polymer particles was a result of the polymer transition from glassy to rubbery state according to water absorption of KSR and plasticizing effect of ibuprofen. The reduction of the Tg of ibuprofen blended with KSR could be better described by the Kwei equation, a modified version of Gordon-Taylor equation.

Authors+Show Affiliations

Faculty of Pharmacy, Srinakharinwirot University , Nakhon-Nayok , Thailand and.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24918171

Citation

Wiranidchapong, Chutima, et al. "Plasticizing Effect of Ibuprofen Induced an Alteration of Drug Released From Kollidon SR Matrices Produced By Direct Compression." Drug Development and Industrial Pharmacy, vol. 41, no. 6, 2015, pp. 1037-46.
Wiranidchapong C, Ruangpayungsak N, Suwattanasuk P, et al. Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression. Drug Dev Ind Pharm. 2015;41(6):1037-46.
Wiranidchapong, C., Ruangpayungsak, N., Suwattanasuk, P., Shuwisitkul, D., & Tanvichien, S. (2015). Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression. Drug Development and Industrial Pharmacy, 41(6), 1037-46. https://doi.org/10.3109/03639045.2014.925917
Wiranidchapong C, et al. Plasticizing Effect of Ibuprofen Induced an Alteration of Drug Released From Kollidon SR Matrices Produced By Direct Compression. Drug Dev Ind Pharm. 2015;41(6):1037-46. PubMed PMID: 24918171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression. AU - Wiranidchapong,Chutima, AU - Ruangpayungsak,Nuchnan, AU - Suwattanasuk,Pattaraporn, AU - Shuwisitkul,Duangratana, AU - Tanvichien,Sujimon, Y1 - 2014/06/11/ PY - 2014/6/12/entrez PY - 2014/6/12/pubmed PY - 2016/2/26/medline KW - Glass transition temperature KW - Gordon–Taylor equation KW - Kollidon SR KW - Kwei equation KW - ibuprofen KW - in-vitro dissolution SP - 1037 EP - 46 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 41 IS - 6 N2 - The objectives of this study were to investigate the effect of storage temperature on drug release from matrices containing 10, 40 and 70% w/w ibuprofen in Kollidon® SR (KSR). The matrix tablets were produced by direct compression and then kept at 30 and 45 °C for 3 months. Drug release from the matrix tablets was examined after storage for 0, 1, 4 and 12 weeks. Scanning electron microscope was used to reveal physical appearance of the tablet surface at the respective time intervals. In addition, differential scanning calorimeter was used to investigate glass transition temperature (Tg) of ibuprofen in KSR at 0-100% w/w based on the principle of Gordon-Taylor equation. At 45 °C, the dissolution of ibuprofen in KSR as well as the coalescence of polymer particles were observed to be higher than those of storage at 30 °C. The physical state of ibuprofen dispersed in the polymeric matrix and degree of polymer coalescence led to the variation of drug release. The coalescence of polymer particles was a result of the polymer transition from glassy to rubbery state according to water absorption of KSR and plasticizing effect of ibuprofen. The reduction of the Tg of ibuprofen blended with KSR could be better described by the Kwei equation, a modified version of Gordon-Taylor equation. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/24918171/Plasticizing_effect_of_ibuprofen_induced_an_alteration_of_drug_released_from_Kollidon_SR_matrices_produced_by_direct_compression_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2014.925917 DB - PRIME DP - Unbound Medicine ER -