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Anxiolytic-like effect of Illicium verum fruit oil, trans-anethole and related compounds in mice.
Phytother Res 2014; 28(11):1710-2PR

Abstract

The fruit of Illicium verum Hook. f. (star anise) is used by many as a spice. The fragrance of I. verum fruit is characteristically anise-like. In this study, hexane-extracted I. verum fruit oil (IVO), trans-anethole as the main component, and related compounds (propiophenone, 4'-methoxy-propiophenone, trans-β-methylstyrene) were analyzed in order to clarify the emotional effect of inhaling the fragrance of I. verum fruit. As a result, although 4 μL/L air IVO did not exhibit an anxiolytic-like effect, 1 μL/L air trans-anethole exhibited a significant effect (p < 0.05). Moreover, the anxiolytic-like effect of 1 μL/L air trans-anethole was significantly greater than 1 μL/L air propiophenone and 1 μL/L air 4'-methoxy-propiophenone (p < 0.05). Thus, the anxiolytic-like effect of trans-anethole was confirmed, and it is proposed that the methoxyl group and 1-propenyl group in the para position of the benzene ring are necessary for the effect.

Authors+Show Affiliations

Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24919985

Citation

Miyagawa, Michiyo, et al. "Anxiolytic-like Effect of Illicium Verum Fruit Oil, Trans-anethole and Related Compounds in Mice." Phytotherapy Research : PTR, vol. 28, no. 11, 2014, pp. 1710-2.
Miyagawa M, Satou T, Yukimune C, et al. Anxiolytic-like effect of Illicium verum fruit oil, trans-anethole and related compounds in mice. Phytother Res. 2014;28(11):1710-2.
Miyagawa, M., Satou, T., Yukimune, C., Ishibashi, A., Seimiya, H., Yamada, H., ... Koike, K. (2014). Anxiolytic-like effect of Illicium verum fruit oil, trans-anethole and related compounds in mice. Phytotherapy Research : PTR, 28(11), pp. 1710-2. doi:10.1002/ptr.5190.
Miyagawa M, et al. Anxiolytic-like Effect of Illicium Verum Fruit Oil, Trans-anethole and Related Compounds in Mice. Phytother Res. 2014;28(11):1710-2. PubMed PMID: 24919985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytic-like effect of Illicium verum fruit oil, trans-anethole and related compounds in mice. AU - Miyagawa,Michiyo, AU - Satou,Tadaaki, AU - Yukimune,Chihiro, AU - Ishibashi,Ayumi, AU - Seimiya,Haruna, AU - Yamada,Hideo, AU - Hasegawa,Toshio, AU - Koike,Kazuo, Y1 - 2014/06/11/ PY - 2014/02/26/received PY - 2014/05/07/revised PY - 2014/05/22/accepted PY - 2014/6/13/entrez PY - 2014/6/13/pubmed PY - 2015/2/11/medline KW - Illicium verum KW - anxiolytic-like effect KW - structure-activity relationship KW - trans-anethole SP - 1710 EP - 2 JF - Phytotherapy research : PTR JO - Phytother Res VL - 28 IS - 11 N2 - The fruit of Illicium verum Hook. f. (star anise) is used by many as a spice. The fragrance of I. verum fruit is characteristically anise-like. In this study, hexane-extracted I. verum fruit oil (IVO), trans-anethole as the main component, and related compounds (propiophenone, 4'-methoxy-propiophenone, trans-β-methylstyrene) were analyzed in order to clarify the emotional effect of inhaling the fragrance of I. verum fruit. As a result, although 4 μL/L air IVO did not exhibit an anxiolytic-like effect, 1 μL/L air trans-anethole exhibited a significant effect (p < 0.05). Moreover, the anxiolytic-like effect of 1 μL/L air trans-anethole was significantly greater than 1 μL/L air propiophenone and 1 μL/L air 4'-methoxy-propiophenone (p < 0.05). Thus, the anxiolytic-like effect of trans-anethole was confirmed, and it is proposed that the methoxyl group and 1-propenyl group in the para position of the benzene ring are necessary for the effect. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/24919985/Anxiolytic_like_effect_of_Illicium_verum_fruit_oil_trans_anethole_and_related_compounds_in_mice_ L2 - https://doi.org/10.1002/ptr.5190 DB - PRIME DP - Unbound Medicine ER -