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Evaluation of microencapsulated islets in agarose gel as bioartificial pancreas by studies of hormone secretion in culture and by xenotransplantation.
Diabetes. 1989 Jan; 38 Suppl 1:224-5.D

Abstract

Islets were microencapsulated in agarose gel for examination of the possible use of microencapsulated islets as a bioartificial pancreas. Microencapsulated islets secreted insulin into the culture medium (RPMI-1640) and could rapidly increase their insulin release in response to a glucose challenge even after greater than 100 days. Hamster islets in groups of 400-1000 encapsulated in microbeads containing 11-14% (wt/wt) agarose were xenogenically transplanted into the peritoneal cavity of five diabetic mice. The longest normoglycemic period in these mice was 53 days, which was markedly longer than the normoglycemic period obtained by nonencapsulated islets. Agarose seems to be a suitable basic material for encapsulating islets, because the islets can easily be microencapsulated without any adverse effect on the islet function.

Authors+Show Affiliations

National Cardiovascular Center Research Institute, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2492009

Citation

Iwata, H, et al. "Evaluation of Microencapsulated Islets in Agarose Gel as Bioartificial Pancreas By Studies of Hormone Secretion in Culture and By Xenotransplantation." Diabetes, vol. 38 Suppl 1, 1989, pp. 224-5.
Iwata H, Amemiya H, Matsuda T, et al. Evaluation of microencapsulated islets in agarose gel as bioartificial pancreas by studies of hormone secretion in culture and by xenotransplantation. Diabetes. 1989;38 Suppl 1:224-5.
Iwata, H., Amemiya, H., Matsuda, T., Takano, H., Hayashi, R., & Akutsu, T. (1989). Evaluation of microencapsulated islets in agarose gel as bioartificial pancreas by studies of hormone secretion in culture and by xenotransplantation. Diabetes, 38 Suppl 1, 224-5.
Iwata H, et al. Evaluation of Microencapsulated Islets in Agarose Gel as Bioartificial Pancreas By Studies of Hormone Secretion in Culture and By Xenotransplantation. Diabetes. 1989;38 Suppl 1:224-5. PubMed PMID: 2492009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of microencapsulated islets in agarose gel as bioartificial pancreas by studies of hormone secretion in culture and by xenotransplantation. AU - Iwata,H, AU - Amemiya,H, AU - Matsuda,T, AU - Takano,H, AU - Hayashi,R, AU - Akutsu,T, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 224 EP - 5 JF - Diabetes JO - Diabetes VL - 38 Suppl 1 N2 - Islets were microencapsulated in agarose gel for examination of the possible use of microencapsulated islets as a bioartificial pancreas. Microencapsulated islets secreted insulin into the culture medium (RPMI-1640) and could rapidly increase their insulin release in response to a glucose challenge even after greater than 100 days. Hamster islets in groups of 400-1000 encapsulated in microbeads containing 11-14% (wt/wt) agarose were xenogenically transplanted into the peritoneal cavity of five diabetic mice. The longest normoglycemic period in these mice was 53 days, which was markedly longer than the normoglycemic period obtained by nonencapsulated islets. Agarose seems to be a suitable basic material for encapsulating islets, because the islets can easily be microencapsulated without any adverse effect on the islet function. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/2492009/Evaluation_of_microencapsulated_islets_in_agarose_gel_as_bioartificial_pancreas_by_studies_of_hormone_secretion_in_culture_and_by_xenotransplantation_ L2 - https://diabetes.diabetesjournals.org/lookup/pmidlookup?view=long&pmid=2492009 DB - PRIME DP - Unbound Medicine ER -