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Quantitative analysis of dietary protein intake and stroke risk.
Neurology 2014; 83(1):19-25Neur

Abstract

OBJECTIVE

To perform a meta-analysis of prospective studies to evaluate the relation between dietary protein intake and stroke risk.

METHODS

Relevant studies were identified by searching PubMed and Embase through November 2013, and by reviewing the reference lists of retrieved articles. We included prospective cohort studies that reported relative risks (RRs) with 95% confidence intervals (CIs) for the association between dietary protein intake and stroke risk.

RESULTS

The meta-analysis included 7 prospective studies involving 254,489 participants. The pooled RR of stroke for the highest compared with the lowest dietary protein intake was 0.80 (95% CI 0.66-0.99). Dose-response analysis indicated that a 20-g/d increment in dietary protein intake was associated with a 26% reduction in stroke risk. Stratifying by protein type, the RR of stroke for animal protein was 0.71 (95% CI 0.50-0.99). Sensitivity analysis restricted to studies with control for common risk factors yielded similar results, and omission of any single study did not change the overall result.

CONCLUSION

These findings suggest that moderate dietary protein intake may lower the risk of stroke.

Authors+Show Affiliations

From the Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China.From the Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China.From the Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China.From the Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China.From the Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China. xfliu2@vip.163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24920855

Citation

Zhang, Zhizhong, et al. "Quantitative Analysis of Dietary Protein Intake and Stroke Risk." Neurology, vol. 83, no. 1, 2014, pp. 19-25.
Zhang Z, Xu G, Yang F, et al. Quantitative analysis of dietary protein intake and stroke risk. Neurology. 2014;83(1):19-25.
Zhang, Z., Xu, G., Yang, F., Zhu, W., & Liu, X. (2014). Quantitative analysis of dietary protein intake and stroke risk. Neurology, 83(1), pp. 19-25. doi:10.1212/WNL.0000000000000551.
Zhang Z, et al. Quantitative Analysis of Dietary Protein Intake and Stroke Risk. Neurology. 2014 Jul 1;83(1):19-25. PubMed PMID: 24920855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative analysis of dietary protein intake and stroke risk. AU - Zhang,Zhizhong, AU - Xu,Gelin, AU - Yang,Fang, AU - Zhu,Wusheng, AU - Liu,Xinfeng, Y1 - 2014/06/11/ PY - 2014/6/13/entrez PY - 2014/6/13/pubmed PY - 2014/8/26/medline SP - 19 EP - 25 JF - Neurology JO - Neurology VL - 83 IS - 1 N2 - OBJECTIVE: To perform a meta-analysis of prospective studies to evaluate the relation between dietary protein intake and stroke risk. METHODS: Relevant studies were identified by searching PubMed and Embase through November 2013, and by reviewing the reference lists of retrieved articles. We included prospective cohort studies that reported relative risks (RRs) with 95% confidence intervals (CIs) for the association between dietary protein intake and stroke risk. RESULTS: The meta-analysis included 7 prospective studies involving 254,489 participants. The pooled RR of stroke for the highest compared with the lowest dietary protein intake was 0.80 (95% CI 0.66-0.99). Dose-response analysis indicated that a 20-g/d increment in dietary protein intake was associated with a 26% reduction in stroke risk. Stratifying by protein type, the RR of stroke for animal protein was 0.71 (95% CI 0.50-0.99). Sensitivity analysis restricted to studies with control for common risk factors yielded similar results, and omission of any single study did not change the overall result. CONCLUSION: These findings suggest that moderate dietary protein intake may lower the risk of stroke. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/24920855/Quantitative_analysis_of_dietary_protein_intake_and_stroke_risk_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=24920855 DB - PRIME DP - Unbound Medicine ER -